Detection of RXFP1 receptors in skin biopsies from children with congenital adrenal hyperplasia: A preliminary report

Journal of Pediatric Urology

Volumn 6, Issue 4, 2010, Pages 389-395

  Cooney, Timothy E ^a   Gor, Ronak A ^b   Pfaff, Donald W ^c   Schober, Justine M ^a,c  

^a HAMOT MEDICAL CENTER   (United States)

^b LAKE ERIE COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Congenital adrenal hyperplasia; Keratinocytes; Receptors; Relaxin

Indexed keywords

COLLAGENASE; CORTICOSTEROID; HORMONE RECEPTOR; MINERALOCORTICOID; PROTEIN; RELAXIN; RXFP 1 RECEPTOR; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; RECEPTOR; RXFP1 PROTEIN, HUMAN;

ARTICLE; BASEMENT MEMBRANE; CASE REPORT; CHILD; CONGENITAL ADRENAL HYPERPLASIA; DOWN REGULATION; ENZYME INDUCTION; EPITHELIUM; FEMALE; HORMONE SUBSTITUTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCHOOL CHILD; SKIN BIOPSY; STAINING; BIOPSY; BIOSYNTHESIS; CHEMISTRY; METABOLISM; PATHOLOGY; SKIN;

ADRENAL HYPERPLASIA, CONGENITAL; BIOPSY; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; SKIN;

EID: 77956748339     PISSN: 14775131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpurol.2009.10.003     Document Type: Article

References (55)

1. D.P. Merke, and S.R. Bornstein Congenital adrenal hyperplasia Lancet 365 2005 2125 2136
2. D. Merke, and M. Kabbani Congenital adrenal hyperplasia: epidemiology, management and practical drug treatment Paediatr Drugs 3 2001 599 611 (Pubitemid 32848349)
3. C.M. Ogilvie, N.S. Crouch, G. Rumsby, S.M. Creighton, L.M. Liao, and G.S. Conway Congenital adrenal hyperplasia in adults: a review of medical, surgical and psychological issues Clin Endocrinol 64 2006 2 11
4. N.K. Alizai, D.F. Thomas, R.J. Lilford, A.G. Batchelor, and N. Johnson Feminizing genitoplasty for congenital adrenal hyperplasia: what happens at puberty? J Urol 161 1999 1588 1591
5. C.L. Minto, L.M. Liao, C.R. Woodhouse, P.G. Ransley, and S.M. Creighton The effect of clitoral surgery on sexual outcome in individuals who have intersex conditions with ambiguous genitalia: a cross-sectional study Lancet 361 2003 1252 1257
6. M.M. Bailez, J.P. Gearhart, C. Migeon, and J. Rock Vaginal reconstruction after initial construction of the external genitalia in girls with salt-wasting adrenal hyperplasia J Urol 148 1992 680 684
7. S. Krege, K.H. Walz, B.P. Hauffa, I. Körner, and H. Rübben Long-term follow-up of female patients with congenital adrenal hyperplasia from 21-hydroxylase deficiency, with special emphasis on the results of vaginoplasty BJU Int 86 2000 253 259
8. S. Merlo, G. Frasca, P.L. Canonico, and M.A. Sortino Differential involvement of estrogen receptor alpha and estrogen receptor beta in the healing promoting effect of estrogen in human keratinocytes J Endocrinol 200 2009 189 197
9. D.E. Morales, K.A. McGowan, D.S. Grant, S. Maheshwari, D. Bhartiya, and M.C. Cid Estrogen promotes angiogenic activity in human umbilical vein endothelial cells in vitro and in a murine model Circulation 91 1995 755 763
10. M. Florian, Y. Lu, M. Angle, and S. Magder Estrogen induced changes in Akt-dependent activation of endothelial nitric oxide synthase and vasodilation Steroids 69 2004 637 645
11. R.G. Smolders, M.J. van der Mooren, P. Kenemans, P.W. van der Linden, C.D. Stehouwer, and P. Sipkema 17 beta-Estradiol induces a rapid, endothelium-dependent, sex-specific vasodilatation in spontaneous constricted rat arterioles Am J Obstet Gynecol 187 2002 375 381
12. G.S. Ashcroft, and J.J. Ashworth Potential role of estrogens in wound healing Am J Clin Dermatol 4 2003 737 743
13. M. Calvin, M. Dyson, J. Rymer, and S.R. Young The effects of ovarian hormone deficiency on wound contraction in a rat model Br J Obstet Gynaecol 105 1998 223 227
14. O. Jorgensen, and A. Schmidt Influence of sex hormones on granulation tissue formation and on healing of linear wounds Acta Chir Scand 124 1962 1 10
15. B. Pallin, J. Ahonen, and B. Zederfeldt Granulation tissue formation in oophorectomized rats treated with female sex hormones. II. Studies on the amount of collagen and on tensile strength Acta Chir Scand 141 1975 710 714
16. E. Pirilä, N. Ramamurthy, P. Maisi, S. McClain, A. Kucine, and J. Wahlgren Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases-8, -13 and type I collagen expression Curr Med Chem 8 2001 281 294
17. G.S. Ashcroft, S.J. Mills, K. Lei, L. Gibbons, M.J. Jeong, and M. Taniguchi Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor J Clin Invest 111 2003 1309 1318
18. S.C. Gilliver, J.P. Ruckshanthi, M.J. Hardman, T. Nakayama, and G.S. Ashcroft Sex dimorphism in wound healing: the roles of sex steroids and macrophage migration inhibitory factor Endocrinology 149 2008 5747 5757
19. M.K. Calar Serum estradiol levels in infants with and without labial adhesions: the role of estrogen in the etiology and treatment Pediatr Dermatol 24 2007 373 375
20. J. Schober, L. Dulabon, N. Martin-Alguacil, L.M. Kow, and D. Pfaff Significance of topical estrogens to labial fusion and vaginal introital integrity J Pediatr Adolesc Gynecol 19 2006 337 339
21. S. Galey, E.M. Konieczko, C.A. Arnold, and T.E. Cooney Immunohistological detection of relaxin binding to anterior cruciate ligaments Orthopedics 26 2003 1201 1204
22. J.L. Dragoo, R.S. Lee, P. Benhaim, G.A. Finerman, and S.L. Hame Relaxin receptors in the human female anterior cruciate ligament Am J Sports Med 31 2003 577 584
23. J. Lubahn, D. Ivance, E. Konieczko, and T. Cooney Immunohistochemical detection of relaxin binding to the volar oblique ligament J Hand Surg 31A 2006 80 84
24. E.N. Unemori, and E.P. Amento Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts J Biol Chem 265 1990 10681 10685
25. E.N. Unemori, L.B. Pickford, A.L. Salles, C.E. Piercy, B.H. Grove, and M.E. Erikson Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo J Clin Invest 98 1996 2739 2745
26. E.N. Unemori, M.E. Erikson, S.E. Rocco, K.M. Sutherland, D.A. Parsell, and J. Mak Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women Hum Reprod 14 1999 800 806
27. E.N. Unemori, L.S. Beck, W.P. Lee, Y. Xu, M. Siegel, and G. Keller Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis J Invest Dermatol 101 1993 280 285
28. C.S. Samuel, E.N. Unemori, I. Mookerjee, R.A. Bathgate, S.L. Layfield, and J. Mak Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo Endocrinology 145 2004 4125 4133
29. C.S. Samuel, C. Zhao, R.A. Bathgate, C.P. Bond, M.D. Burton, and L.J. Parry Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis FASEB J 17 2003 121 123
30. E.J. Williams, R.C. Benyon, N. Trim, R. Hadwin, B.H. Grove, and M.J. Arthur Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo Gut 49 2001 577 583
31. R. Masterson, T.D. Hewitson, K. Kelynack, M. Martic, L. Parry, and R. Bathgate Relaxin down-regulates renal fibroblast function and promotes matrix remodeling in vitro Nephrol Dial Transpl 19 2004 544 552
32. Negishi S, Li Y, Kuroda R. The improvement of injured muscle healing by relaxin therapy (Poster 1218). 49th Annual meeting of the orthopaedic research society. New Orleans, Louisiana; 2-5 February 2003.
33. T.E. Cooney, J.M. Schober, J.D. Lubahn, and E.M. Konieczko Relaxin's involvement in extracellular matrix homeostasis Ann N Y Acad Sci 1160 2009 329 335
34. D.W. Fawcett Bloom and fawcett: a textbook of histology 12th ed. 1994 Chapman & Hall New York p. 526
35. G.N. Stemmermann, W. Mesiona, F.C. Greenwood, and G.D. Bryant-Greenwood Immunocytochemical identification of a relaxin-like protein in gastrointestinal epithelium and carcinoma: a preliminary report J Endocrinol 140 1994 321 325
36. I. Mookerjee, N.R. Solly, S.G. Royce, G.W. Tregear, C.S. Samuel, and M.L. Tang Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease Endocrinology 147 2006 754 761
37. J.M. Brandner, S. Zacheja, P. Houdek, I. Moll, and R. Lobmann Expression of matrix metalloproteinases, cytokines, and connexins in diabetic and nondiabetic human keratinocytes before and after transplantation into an ex vivo wound-healing model Diabetes Care 31 2008 114 120
38. A. Ghaffari, R.T. Kilani, and A. Ghahary Keratinocyte-conditioned media regulate collagen expression in dermal fibroblasts J Invest Dermatol 129 2009 340 347
39. A. Ghahary, Y. Marcoux, F. Karimi-Busheri, Y. Li, E.E. Tredget, and R.T. Kilani Differentiated keratinocyte-releasable stratifin (14-3-3 sigma) stimulates MMP-1 expression in dermal fibroblasts J Invest Dermatol 124 2005 170 177
40. C. Vélez-Delvalle, M. Marsch-Moreno, F. Castro-Muñozledo, Y.J. Bolivar-Flores, and W. Kuri-Harcuch Fibromodulin gene is expressed in human epidermal keratinocytes in culture and in human epidermis in vivo Biochem Biophys Res Commun 371 2008 420 424
41. I. Zervolea, H. Pratsinis, S. Tsagarakis, N. Karavitaki, D. Stathakos, and N. Thalassinos The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome Eur J Endocrinol 152 2005 895 902
42. R.A. Ignotz, and J. Massagué Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix J Biol Chem 261 1986 4337 4345
43. S. Frank, M. Madlener, and S. Werner Transforming growth factors ß1, ß2, and ß3 and their receptors are differentially regulated during normal and impaired wound healing J Biol Chem 271 1996 10188 10193
44. Y. Wen, Y.Y. Zhao, M.L. Polan, and B. Chen Effect of relaxin on TGF-ß1 expression in cultured vaginal fibroblasts from women with stress urinary incontinence Reprod Sci 15 2008 312 320
45. O. Evensen, and N.J. Olesen Immunohistochemical detection of VHS virus in paraffin-embedded specimens of rainbow trout (Oncorhynchus mykiss): the influence of primary antibody, fixative, and antigen unmasking on method sensitivity Vet Pathol 34 1997 253 261
46. M.J. Yaeger The diagnostic sensitivity of immunohistochemistry for the detection of porcine reproductive and respiratory syndrome virus in the lung of vaccinated and unvaccinated swine J Vet Diagn Invest 14 2002 15 19
47. D.P. Wood Jr., E.R. Banks, S. Humphreys, and V.M. Rangnekar Sensitivity of immunohistochemistry and polymerase chain reaction in detecting prostate cancer cells in bone marrow J Histochem Cytochem 42 1994 505 511
48. J.R. Teerlink, M. Metra, G.M. Felker, P. Ponikowski, A.A. Voors, and B.D. Weatherley Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study Lancet 373 2009 1429 1439
49. R.J. Bell, M. Permezel, A. MacLennan, C. Hughes, D. Healy, and S. Brennecke A randomized, double-blind, placebo-controlled trial of the safety of vaginal recombinant human relaxin for cervical ripening Obstet Gynecol 82 1993 328 333
50. J.R. Seibold, P.J. Clements, D.E. Furst, M.D. Mayes, D.A. McCloskey, and L.W. Moreland Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis J Rheumatol 25 1998 302 307
51. D. Khanna, P.J. Clements, D.E. Furst, J.H. Korn, M. Ellman, and N. Rothfield Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial Arthritis Rheum 60 2009 1102 1111
52. American Academy of Pediatrics Timing of elective surgery on the genitalia of male children with particular reference to the risks, benefits, and psychological effects of surgery and anesthesia Pediatrics 97 1996 590 594
53. G.S. Ashcroft, J. Dodsworth, E. van Boxtel, R.W. Tarnuzzer, M.A. Horan, and G.S. Schultz Estrogen accelerates cutaneous wound healing associated with an increase in TGF-beta1 levels Nat Med 3 1997 1209 1215
54. G.S. Ashcroft, T. Greenwell-Wild, M.A. Horan, S.M. Wahl, and M.W. Ferguson Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response Am J Pathol 155 1999 1137 1146
55. M.J. Hardman, E. Emmerson, L. Campbell, and G.S. Ashcroft Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice Endocrinology 149 2008 551 557