Leukaemia inhibitory factor inhibits cardiomyogenesis of mouse embryonic stem cells via STAT3 activation

Folia Biologica

Volumn 56, Issue 4, 2010, Pages 165-172

  Vesela I ^a   Kotasova H ^a   Jankovska S ^a   Prochazkova J ^a   Pacherník, Jiří ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Cardiomyogenesis; Embryonic stem cell; Leukaemia inhibitory factor; Serum free; STAT3

Indexed keywords

BETA TUBULIN; FIBROBLAST GROWTH FACTOR 5; LEUKEMIA INHIBITORY FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MYOSIN HEAVY CHAIN; OCTAMER TRANSCRIPTION FACTOR 4; STAT3 PROTEIN; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYONIC STEM CELL; HEART DEVELOPMENT; HEART MUSCLE CELL; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

EID: 77956690023     PISSN: 00155500     EISSN: 25337602     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bader, A., Al-Dubai, H., Weitzer, G. (2000) Leukaemia inhibitory factor modulates cardiogenesis in embryoid bodies in opposite fashions. Circ. Res. 86, 787-794.
2. Boiani, M., Schöler, H. R. (2005) Regulatory networks in embryo-derived pluripotent stem cells. Nat. Rev. Mol. Cell Biol. 11, 872-884.
3. Boheler, K. R., Czyz, J., Tweedie, D., Yang, H. T., Anisimov, S. V., Wobus, A. M. (2002) Differentiation of pluripotent embryonic stem cells into cardiomyocytes. Circ. Res. 91, 189-201.
4. Bryja, V., Pacherník, J., Vondráček, J., Souček, K., Čajánek, L., Horvath, V., Holubcová, Z., Dvořák, P., Hampl, A. (2008) Lineage specific composition of cyclin D-CDK4/CDK6-p27 complexes reveals distinct functions of CDK4, CDK6 and individual D-type cyclins in differentiating cells of embryonic origin. Cell Prolif. 41, 875-93.
5. Chung, B. M., Kang, H. C., Han, S. Y., Heo, H. S., Lee, J. J., Jeon, J., Lim, J. Y., Shin, I., Hong, S. H., Cho, Y. S., Kim, C. G. (2006) Jak2 and Tyk2 are necessary for lineage-specific differentiation, but not for the maintenance of self-renewal of mouse embryonic stem cells. Biochem. Biophys. Res. Commun. 351, 682-688.
6. Deng, C. X., Wynshaw-Boris, A., Shen, M. M., Daugherty, C., Ornitz, D. M., Leder, P. (1994) Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes. Dev. 8, 3045-3057.
7. Doetschman, T. C., Eistetter, H., Katz, M., Schmidt, W., Kemler, R. (1985) The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium. J. Embryol. Exp. Morphol. 87, 27-45.
8. Esner, M., Pachernik, J., Hampl, A., Dvorak, P. (2002) Targeted disruption of fibroblast growth factor receptor-1 blocks maturation of visceral endoderm and cavitation in mouse embryoid bodies. Int. J. Dev. Biol. 46, 817-825.
9. Evans, M. J., Kaufman, M. H. (1981) Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156.
10. Fischer, P., Hilfiker-Kleiner, D. (2007) Survival pathway in hypertrophy and heart failure: The gp130-STAT3 axis. Basic Res. Cardiol. 102, 279-297. (Pubitemid 46909707)
11. Foshay, K., Rodriguez, G., Hoel, B., Narayan, J., Gallicano, G. I. (2005) JAK2/STAT3 directs cardiomyogenesis within murine embryonic stem cells in vitro. Stem Cells 23, 530-543.
12. Heinrich, P. C., Behrmann, I., Haan, S., Hermanns, H. M., Muller-Newen, G., Schaper, F. (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374, 1-20.
13. Keller, G. (2005) Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 19, 1129-1155.
14. Krejci, J., Pachernik, J., Hampl, A., Dvorak, P. (2008) In vitro labelling of mouse embryonic stem cells with SPIO nanoparticles. Gen. Physiol. Biophys. 27, 164-173.
15. Martin, G. R. (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA 78, 7634-7638.
16. Murashov, A. K., Pak, E. S., Katwa, L. C. (2005) Parallel development of cardiomyocytes and neurons in embryonic stem cell culture. Biochem. Biophys. Res. Commun. 332, 653-656.
17. Murray, P., Edgar, D. (2001) The regulation of embryonic stem cell differentiation by leukaemia inhibitory factor (LIF). Differentiation 68, 227-234.
18. Niwa, H., Burdon, T., Chambers, I., Smith, A. (1998) Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 12, 2048-2060.
19. Pachernik, J., Esner, M., Bryja, V., Dvorak, P., Hampl, A. (2002) Neural differentiation of mouse embryonic stem cells grown in monolayer. Reprod. Nutr. Dev. 42, 317-326.
20. Pachernik, J., Horvath, V., Kubala, L., Dvorak, P., Kozubik, A., Hampl, A. (2007) Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells. Folia Biol. (Praha) 53, 157-163.
21. Rajasingh, J., Bord, E., Hamada, H., Lambers, E., Qin, G., Losordo, D. W., Kishore, R. (2007) STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction. Circ. Res. 101, 910-918.
22. Rathjen, P. D., Nichols, J., Toth, S., Edwards, D. R., Heath, J. K., Smith, A. G. (1990) Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations. Genes. Dev. 4, 2308-2318.
23. Seiler, P., Plenz, G., Deng, M. C. (2001) The interleukin-6 cytokine system in embryonic development, embryo-maternal interactions and cardiogenesis. Eur. Cytokine Netw. 12, 15-21.
24. Shellard, J., Perreau, J., Brulet, P. (1996) Role of leukemia inhibitory factor during mammalian development. Eur. Cytokine Netw. 7, 699-712.
25. Taga, T. (1997) The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines. Ann. Med. 29, 63-72.
26. Wei, H., Juhasz, O., Li, J., Tarasova, Y. S., Boheler, K. R. (2005) Embryonic stem cells and cardiomyocyte differentiation: phenotypic and molecular analyses. J. Cell Mol. Med. 9, 804-817.
27. Yang, J., Stark, G. R. (2008) Roles of unphosphorylated STATs in signaling. Cell Res. 18, 443-451.