The role of dendritic cells and other immune mechanisms during human infection with Mycobacterium tuberculosis

International Journal of Biomathematics

Volumn 2, Issue 1, 2009, Pages 69-105

  Magombedze, Gesham ^a   Garira, Winston ^a,b   Mwenje, Eddie ^a  

^a NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Zimbabwe)

^b UNIVERSITY OF VENDA   (South Africa)

Author keywords

dendritic cells; draining lymph node; mathematical modeling; Mycobacterium tuberculosis (Mtb)

Indexed keywords

EID: 77956651697     PISSN: 17935245     EISSN: 17937159     Source Type: Journal    
DOI: 10.1142/S1793524509000534     Document Type: Article

References (25)

1. R. Medzhitov and C. Janeway, Advances in immunology: Review articles, New. Eng. J. Med. 338 (2000).
2. L. Taillex et al., Constrained intracellular survival of Mycobacterium tuberculosis in human dendritic cells, J. Immunol. 170 (2003) 1939-1948.
3. L. F. Flynn and J. Chan, Tuberculosis: Latency and reactivation: Minireview, Infection Immunity 69(7) (2001) 4195-4201.
4. S. M. Santini et al., Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice, 191 (2000) 1777-1788.
5. B. N. Lambrecht, J.-B. Prins and H. C. Hoogsteden, Lung dendritic cells and host immunity to infection, Eur. Respir. J. 18 (2001) 692-704.
6. C. W. Cutler, R. Jotwani and B. Pulendran, Dendritic cells: Immune saviors or achilles's heel: Minireview, Infection Immunity 69 (2001) 4703-4708.
7. D. Kirschner, Dynamics of co-infection with M.tuberculosis and HIV-1, Theor. Popul. Biol. 55 (1999) 94-109.
8. K. Palucka and J. Banchereau, Dendritic cells: A link between innate and adaptive immunity, J. Clin. Immunol. 19 (1999) 1.
9. D. Fortsch, M. Rollinghoff and S. Stenger, IL-10 Converts human dendritic cells into macrophage-like cells with increased antibacterial activity against virulent Mycobacterium tuberculosis, J. Immunol. 165 (2000) 978-987.
10. A. W. Hanekom et al., Mycobacterium tuberculosis inhibits maturation of human monocyte-derived dendritic cells in vitro, J. Infectiuos. Diseases 188 (2003) 257-66.
11. M. L. Kapsenberg, Dendritic-cell control of pathogen-driven T-cell polarization, Nature Rev. 3 (2003) 984.
12. A. Langenkamp, M. Messi, A. Lanzavecchia and F. Sallusto, Kinetics of dendritic cell activation: Impact on priming TH1, TH2 and nonpolarized T cells, Nat. Immunol. 1(4) (2000) 311.
13. A. Martin-Fontecha et al., Regulation of dendritic cell migration to the draining lymph node: Impact on T Lymphocyte traffic and priming, J. Exp. Med. 198 (2003) 615-621.
14. D. Kirschner, Using mathematics to understanding HIV immune dynamics, Notices AIMS 43 (1996) 191-202.
15. R. J. North, Mice incapable of making IL-4 and IL-10 display normal resistance in infection with Mycobacterium tuberculosis, Clin. Exp. Immunol. 113 (1998) 2827.
16. J. E.Wigginton and D. Kischner, A model to predict cell mediated immune regulatory mechanisms during human infection with Mycobacterium tuberculosis, J. Immunol. 166(3) (2001) 1951.
17. S. Marino and D. Kirschner, The human immune response to Mycobacterium tuberculosis in lung and lymph node, J. Theor. Biol. 227 (2004) 463-486.
18. S. Stenger, R. Mazzaccaro, K. Uyemura, S. Cho, P. Bames, J. Rosat, A. Sette, M. Brenner, S. Porelli, B. Bloom and R. Modlin, Differential effects of cytolytic T cell subsets on intracellular infection, Science 276 (1997) 1684-7.
19. S. Stenger, D. A. Hanson, R. Teitelbaum, P. Dewan, K. R. Niazi, C. J. Froelich, T. Ganz, S. Thomauszynski, A. Melian, C. Bogdan, S. A. Porcelli, B. R. Blomm, A. M. Krensky and R. L. Modlin, An anti-microbial activity of cytotoxic T cells mediated by granulysin, Science 282 (1998) 121-5.
20. J. L. Flynn, M. M. Goldstein, J. Chan, K. J. Triebold, K. Pfeffer, C. J. Lowenstein et al., Tumor necrosis factor-A is required in the protective immune response against Mycobacterium tuberculosis in mice, Immunity 2 (1995) 561-72.
21. J. L. Flynn, Immunology of tuberculosis and implications in vaccine developments, Tuberculosis 84 (2004) 93-101.
22. D. Sud, C. Bigbee, J. L. Flynn and D. E. Kirschner, Contribution of CD8+ T cells of Mycobacterium tuberculosis infection, J. Immunol. 176 (2006) 4296-4314.
23. G. Magombedze, W. Garira and E. Mwenje, Modelling the human immune response mechanisms to Mycobacterium tuberculosis infection in the lungs, Math. Biosci. Engin. 3(4) (2006) 661-682.
24. S. Ganguli, D. Gammack and D. E. Kirschner, A metapopulation model of granuloma formation in the ling during infection with Mycobacterium tuberculosis, Math. Biosci. Engin. 2 (2005) 535-560.
25. A. C. Janeway, P. Travers, M. Walport and J. M. Shlomchik, Immuno Biology: The Immune System in Health and Disease (Garland Science Publishing, 2005).