Modelling the human immune response mechanisms to mycobacterium tuberculosis infection in the lungs

Mathematical Biosciences and Engineering

Volumn 3, Issue 4, 2006, Pages 661-682

  Magombedze, Gesham ^a   Garira, Winston ^a   Mwenje, Eddie ^a  

^a NATIONAL UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Zimbabwe)

Author keywords

Cytotoxic lymphocytes (CTLs); Mycobacterium tuberculosis (Mtb)

Indexed keywords

BACTERIA (MICROORGANISMS); MYCOBACTERIUM TUBERCULOSIS;

EID: 33846994373     PISSN: 15471063     EISSN: 15510018     Source Type: Journal    
DOI: 10.3934/mbe.2006.3.661     Document Type: Article

References (29)

1. Antia J., Koella J.C., Perrot V. MODELS OF WITHIN-HOST DYNAMICS OF PERSISTENT MY-COBACTERIAL INFECTIONS. Biological Sciences. 1368(1996) 257-263.
2. Canetti G. THE TUBERCLE BACILLUS IN THE PULMONARY LESION IN MAN. Springer Publishing Co., New York, 1955.
3. North R.J., and Yu-Jin Jung. IMMUNITY TO TUBERCULOSIS Annu. Rev. Immunol. 22(2004) 599-623.
4. Myrvik Q.N., Leake E.S., and Wright M.J. DISRUPTION OF PHAGOSOMAL MEMBRANES OF NORMAL ALVEOLAR MACROPHAGES BY THE H37RV STRAIN OF MYCOBACTERIUM TUBERCULOSIS. Am. Rev. Respir. Dis. 129(1984) 322.
5. Armstrong J.A., and Hart P.D. RESPONSE OF CULTURED MACROPHAGES TO MYCOBACTERIUM TUBERCULOSIS, WITH OBSERVATIONS ON FUSION OF LYSOSOMES AND PHAGOSOMBS. J. Exp. Med. 134(1971) 713.
6. Bonecini-Almeida G.M., Chitale S., Boutsikakis I., Geng J., Doo J., He S., and Ho J.L. INDUCTION OF IN VITRO HUMAN MACROPHAGE ANTI-M. TUBERCULOSIS ACTIVITY: REQUIREMENT FOR IFN-γ AND PRIMED LYMPHOCYTES. J. Immunol. 160(1998) 4490.
7. McDonough K., Kress Y., and Bloom B.R. PATHOGENESIS OF TUBERCULOSIS: INTERACTION OF Mycobacterium tuberculosis WITH MACROPHAGES. Infect. Immun. 61(1993) 2763.
8. Lalvani A., Brookes R., Wilkinson R.J., Malin A. S., Pathan A.A., Anderson P., Dockrell H., Pasclo G., Hill A.V. HUMAN CYTOLYTIC AND INTERFERON GAMMA-SECRETING CD8+ T LYMPHOCYTES SPECIFIC FOR Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 95(1), (1998)270.
9. Skinner M.A., Yuan S., Prestidge R., Chuk D., Watson J.D., Tan P.L. IMMUNIZATION WITH HEAT-KILLED MYCOBACTERIUM VACOUE STIMULATES CD8+ CYTOTOXIC T CELLS SPECIFIC FOR MACROPHAGES INFECTED WITH Mycobacterium Tuberculosis. Infect. Immun. 65(11), (1997) 4525.
10. Tsukaguchi K., Balaji K.N., and Boom W.H. CD4+ ALPHA BETA T CELL AND GAMMA DELTA T CELL RESPONSES TO Mycobacterium tuberculosis. SIMILARITIES AND DIFFERENCES IN AG RECOGNITION CYTOTOXIC EFFECTOR FUNCTION, AND CYTOKINE PRODUCTION. J. Immunol 154(4), (1995) 1786.
11. Wigginton J.E., and Kischner D. A MODEL TO PREDICT CELL MEDIATED IMMUNE REGULATORY MECHANISMS DURING HUMAN INFECTION WITH Mycobacterium tuberculosis. J. Immunol. 166(3), (2001) 1951.
12. Marino S., and Kirscher D. THE HUMAN IMMUNE RESPONSE TO Mycobacterium tuberculosis IN LUNG AND LYMPH NODE. Journal of Theoretical Biology 227(2004) 463-486.
13. Stenger S., Mazzaccaro R., Uyemura K., Cho S., Bames P., Rosat J., Sette A., Brenner M., Porelli S., Bloom B., Modlin R. DIFFERENTIAL EFFECTS OF CYTOLYTIC T CELL SUBSETS ON INTRACELLULAR INFECTION. Science 276(1997) 1684-7.
14. Stenger S., Hanson D.A., Teitelbaum R., Dewan P., Niazi K.R., Proelich C.J., Ganz T., Thomauszynski S., Melian A., Bogdan C., Porcelli S.A., Blomm B.R., Krensky A.M., Modlin R.L. AN ANTI-MICROBIAL ACTIVITY OF CYTOTOXIC T CELLS MEDIATED BY GRANULYSIN. Science 282(1998) 121-5.
15. Ladel C.H., Szalay G., Riedel D., Kaufmann S.H. INTERLEUKIN-12 SECRETION BY Mycobacterium tuberculosis INFECTED MACROPHAGES, infect Immun. 65(1997) 1936-8.
16. Cooper A.M., Magram J., Ferrante J., Orme I.M. INTBRLEUKIN 12 (IL-12) IS CRUCIAL TO THE DEVELOPMENT OF PROTECTIVE IMMUNITY IN MICE INTRAVENOUSLY INFECTED WITH My-cobacterium tuberculosis. J Exp Med. 186(1997) 39-45.
17. Flynn J.L., Goldstein M.M., Chan J., Triebold K.J., Pfeffer K., Lowenstein C.J., et al. TUMOR NECROSIS FACTOR-A IS REQUIRED IN THE PROTECTIVE IMMUNE RESPONSE AGAINST Mycobacterium tuberculosis IN MICE. Immunity. 2(1995) 561-72.
18. Flynn J.L. IMMUNOLOGY OF TUBERCULOSIS AND IMPLICATIONS IN VACCINE DEVELOPMENTS. Tuberculosis. 84(2004) 93-101.
19. Serbina N.V., and Flynn J.L. EARLY EMERGENCE OF CD8+ T CELLS PRIMED FOR PRODUCTION OF TYPE 1 CYTOKNES IN THE LUNGS OF Mycobacterium tuberculosis-INFECTED MICE. Infect Immunology. 67(1999) 3980-8.
20. De Libero G., Flesch I., Kaufmann S.H.E. MYCOBACTERIA REACTIVE LYT-2+ T CELL LINES. Eyr J Immunol. 18(1988) 59-66.
21. Kirschner D. DYNAMICS OF CO-INFECTION WITH M.tuberculosis AND HIV-1. Theoretical Population Biology. 55(1999) 94-109.
22. Caruso A.M., Serabina N., Klein E., Triebold K., Bloom B.R., Flynn J.L. MICE DEFICIENT IN CD4+ T CELLS HAVE ONLY TRANSIENTLY DIMINESHED LEVELS OF IFN-γ, YET SUCCUMB TO TUBERCULOSIS. J Immunol. 162(1999) 5407-16.
23. Vergelli M., Hemmer B., Muraro P.A., Tranquill L., Biddison W.E., Sarin A., McFarland H.F., and Martin R. HUMAN AUTOREACTIVE CD4+T CELL CLONES USE PERFORIN- OR FAS/FAS LIGAND-MEDIATED PATHWAYS FAR TARGET CELL LYSIS. J. Immunol. 160(1997)
24. Keane J., Remold H.G., and Kornfeld H. VIRULENT MYCOBACTERIUM TUBERCULOSIS STRAINS EVADE APOPTOSIS OF INFECTED ALVEOLAR MACROPHAGES. Journal of Immonology. 164(2000) 2016-2020.
25. Serbina N.V., Lazarevic V., and Flynn J.L. CD4+ T CELLS ARE REQUIRED FOR THE DEVELOPMENT OF CYTOTOXIC CD8+ T CELLS DURING MYCOBACTERIUM TUBERCULOSIS INFECTION. The Journal of Immunology. 167(2001) 6991-7000.
26. Schluger N.W., and Rom W.N. THE HOST IMMUNE RESPONSE TO TUBERCULOSIS. Am. J. Respir. Crit. Care. Med. 157(1998) 679-691.
27. Schluger N.W. RECENT ADVANCES IN OUR UNDERSTANDING OF HUMAN HOST RESPONSE TO TUBERCULOSIS. Respir. Res 2(2001) 157-163.
28. Maggi E., Panonchi P., Manetti R., Simonelli C., Picciui M.P., Rugiu F.S., De Carli M., Ricci M., Romagnani S. RECIPROCAL REGULATORY EFFECTS OF IFN-GAMMA AND IL-4 ON THE IN VITRO DEVELOPMENT OF HUMAN TH1 AND TH2 CLONES. J. Immunol. 148(7), (1992) 2142.
29. Szabo S.J., Dighe A.S., Gubler U., Murphy K.M. REGULATION OF THE INTERLEUKIN (IL)-12R BETA 2 SUBUNIT EXPRESSION IN DEVELOPING T HELPER 1 (TH1) AND TH2 CELLS. J. Exp. Med. 185(5), (1997) 817.