Evaluation of protective effects of the alpha lipoic acid after spinal cord injury: An animal study

Injury

Volumn 41, Issue 10, 2010, Pages 1068-1074

  Tas, Nilufer ^a   Bakar, Bulent ^a   Kasimcan, Mustafa Omur ^a   Gazyagci, Serkal ^a   Ayva, Sebnem Kupana ^a   Kilinc, Kamer ^b   Evliyaoglu, Cetin ^c  

^a KIRIKKALE UNIVERSITY   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c Hospitalium Hospital   (Turkey)

Author keywords

Alpha lipoic acid; Lipid peroxidation; Methylprednisolone; Myeloperoxidation; Secondary injury; Spinal cord trauma

Indexed keywords

METHYLPREDNISOLONE; METHYLPREDNISOLONE ACETATE; THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NERVOUS TISSUE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

ANIMALS; APOPTOSIS; FREE RADICALS; LIPID PEROXIDATION; MALE; METHYLPREDNISOLONE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; SPINAL CORD INJURIES; THIOCTIC ACID; TREATMENT FAILURE;

EID: 77956651166     PISSN: 00201383     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.injury.2010.05.027     Document Type: Article

References (21)

1. A.R. Allen Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column JAMA 57 1911 878 880
2. M.S. Beattie Inflammation and apoptosis: linked therapeutic targets in spinal cord injury Trends Mol Med 10 2004 580 583
3. G.P. Biewenga, G.R. Haenen, and A. Bast The pharmacology of the antioxidant lipoic acid Gen Pharmacol 29 1997 315 331
4. A. Bilska, and L. Wlodek Lipoic acid - drug of the future? Pharmacol Rep 57 2005 570 577
5. P. Black, R.S. Markowitz, and V. Cooper Models of spinal cord injury: Part 1. Static load technique Neurosurgery 19 1986 752 762 (Pubitemid 17182143)
6. V. Dhote, and R. Balaraman Anti-oxidant activity mediated neuroprotective potential of trimetazidine on focal cerebral ischaemia-reperfusion injury in rats Clin Exp Pharmacol Physiol 35 2008 630 637
7. F.H. Geisler, F.C. Dorsey, and W.P. Coleman Recovery of motor function after spinal-cord injury - a randomized, placebo-controlled trial with GM-1 ganglioside N Engl J Med 324 1991 1829 1838
8. G. Guízar-Sahagún, I. Grijalva, and H. Salgado-Ceballos Spontaneous and induced aberrant sprouting at the site of injury is irrevelant to motor function outcome in rats with spinal cord injury Brain Res 1013 2004 143 151
9. F. Ildan, A. Oner, and S. Polat Correlation of alterations on Na(+)-K+/Mg+2 ATPase activity, lipid peroxidation and ultrastructural findings following experimental spinal cord injury with and without intravenous methylprednisolone treatment Neurosurg Rev 18 1995 35 44
10. M.Y. Kaynar, M. Hanci, and A. Kafadar The effect of duration of compression on lipid peroxidation after experimental spinal cord injury Neurosurg Rev 21 1998 117 120
11. A. Leskovar, L.J. Moriarty, and J.J. Turek The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems J Exp Biol 203 2000 1783 1795
12. A. Merola, M.F. O'Brien, and B.A. Castro Histologic characterization of acute spinal cord injury treated with intravenous methylprednisolone Orthop Trauma 16 2002 155 161
13. K.M. Mullane, R. Kraemer, and B. Smith Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium J Pharmacol Methods 14 1985 157 167
14. N.H. Nie, C.H. Hull, and J.G. Jenkins SPSS: statistical package for social science 1975 Mc Graw Hill Inc New York
15. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 1979 351 358
16. L. Packer, H.J. Tritschler, and K. Wessel Neuroprotection by the metabolic antioxidant α-lipoic acid Free Radic Biol Med 22 1997 359 378
17. P.G. Popovich, B.T. Stokes, and C.C. Whitacre Concept of autoimmunity following spinal cord injury: possible roles for T lymphocytes in the traumatized central nervous system J Neurosci Res 45 1996 349 363
18. L.J. Reed, B.G. Debusk, I.C. Gunsalus, and C.S. Hornberger Jr Crystalline alpha-lipoic acid; a catalytic agent associated with pyruvate dehydrogenase Science 114 1951 93 94
19. S. Roy, and L. Packer Redox regulation of cell functions by alpha-lipoate: biochemical and molecular aspects Biofactors 8 1998 17 21 (Pubitemid 28332779)
20. S. Torres, H. Salgado-Ceballos, and J.L. Torres Early metabolic reactivation versus antioxidant therapy after a traumatic spinal cord injury in adult rats Neuropathology 30 2010 36 43
21. D. Ziegler Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review Treat Endocrinol 3 2004 173 189