1,3-Dipolar cycloaddition of nitrile oxides to (R)-1-(1-phenylethyl)-3,5- bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: Synthesis and antimycobacterial evaluation of novel enantiomerically pure di- and trispiroheterocycles

Tetrahedron Asymmetry

Volumn 21, Issue 11-12, 2010, Pages 1315-1327

  Kumar, Raju Suresh ^a   Rajesh, Stephen Michael ^a   Perumal, Subbu ^a   Yogeeswari, Perumal ^b   Sriram, Dharmarajan ^b  

^a MADURAI KAMARAJ UNIVERSITY   (India)

^b Medicinal Chemistry and Antimycobacterial Research Laboratory   (India)

Author keywords

1,3 dipolar cycloaddition; Antitubercular activity; Dioxazoles; Nitrile oxide; Spiroisoxazolines

Indexed keywords

(1 PHENYLETHYL) 3,5 BIS [(E) PHENYLMETHYLIDENE] TETRAHYDRO 4(1H) PYRIDINONE; 1 (1PHENYLETHYL) 3,5 BIS [(E) ARYLMETHYLIDENE] TETRAHYDRO 4(H) PYRIDINONE DERIVATIVE; 10 (4 CHLOROPHENYL) 14 [(E) (4 CHLOROPHENYL) METHYLIDENE] 3,9 DIPHENYL 12 [(R) 1 PHENYLETHYL] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 10 (4 CHLOROPHENYL) 14 [(E) 1 (4 CHLOROPHENYL) METHYLIDENE] 3,9 DI (4 ISOPROPYLPHENYL) 12 (1 PHENYLETHYL) 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 10 (4 CHLOROPHENYL) 14 [(E) 1 (4 CHLOROPHENYL) METHYLIDENE] 3,9 DI (4 ISOPROPYLPHENYL) 12 (1 PHENYLETHYL) 1,4,7 TRIOXO 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 10 (4 METHYLPHENYL) 14 [(E) (4 METHYLPHENYL) METHYLIDENE] 3,9 DIPHENYL 12 [(R) 1 PHENYLETHYL 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 10 (4 METHYLPHENYL) 14 [(E) (4 METHYLPHENYL) METHYLIDENE] 3,9 DIPHENYL 12 [(R) 1 PHENYLETHYL] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 3,4,10,11 TETRAPHENYL 13 [(R) 1 PHENYLETHYL] 1,8 DIOXA 2,9,13 TRIAZADISPIRO [4 1 4 3] TETRADECA 2,9 DIEN 6 ONE; 3,5 BIS [(E) (2 BROMOPHENYL) METHYLIDENE] 1 [(R) 1 PHENYLETHYL] TETRAHYDRO 4(1H) PYRIDINONE; 3,5 BIS [(E) (2 CHLOROPHENYL) METHYLIDENE] 1 [(R) 1 PHENYLETHYL] TETRAHYDRO 4(1H) PYRIDINONE; 3,5 BIS [(E) (2,4 DICHLOROPHENYL) METHYLIDENE] 1 [(R) 1 PHENYLETHYL]TETRAHYDRO 4(1H) PYRIDINONE; 3,5 BIS [(E) (4 CHLOROPHENYL) METHYLIDENE] 1 [(R) 1 PHENYLETHYL] TETRAHYDRO 4(1H) PYRIDINONE; 3,5 BIS [(E) (4 METHYLPHENYL) METHYLIDENE] 1 [(R) 1 PHENYLETHYL] TETRAHYDRO 4(1H) PYRIDINONE; 3,5 BIS [(E) 1 NAPHTHYLMETHYLIDENE] 1 [(R) 1 PHENYLETHYL] TETRAHYDRO 4(1H) PYRIDINONE; 3,9 BIS (4 CHLOROPHENYL) 10 (2,4 DICHLOROPHENYL) 14 [(E) (2,4 DICHLOROPHENYL)METHYLIDENE] 12 [(R) 1 PHENYLETHYL] 1,4,7 TRIOXA 2,8,12 TRI AZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 3,9 BIS (4 CHLOROPHENYL) 10 PHENYL 12 [(R) 1 PHENYLETHYL] 14 [(E) PHENYLMETHYLIDENE] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 3,9 BIS(4 CHLOROPHENYL) 10 (4 METHYLPHENYL) 14 [(E) (4 METHYL PHENYL) METHYLIDENE] 12 [(R) 1 PHENYLETHYL] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 3,9,10 TRIPHENYL 12 [(R) 1 PHENYLETHYL] 14 [(E) PHENYLMETHYLIDENE] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 3,9,10 TRIPHENYL 12 [(R) 1 PHENYLETHYL]] 14 [(E) PHENYLMETHYLIDENE] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [ 4 0 4 4] TETRADECA 2,8 DIENE; 3,9,10 TRIS (4 CHLOROPHENYL) 14 [(E) (4 CHLOROPHENYL) METHYLIDENE] 12 [(R) 1 PHENYLETHYL] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; 3,9,10 TRIS(4 CHLOROPHENYL) 14 [(E) (4 CHLOROPHENYL) METHYLIDENE] 12 [(R) 1 PHENYLETHYL] 1,4,7 TRIOXA 2,8,12 TRIAZADISPIRO [4 0 4 4] TETRADECA 2,8 DIENE; ANTIMYCOBACTERIAL AGENT; CIPROFLOXACIN; ETHAMBUTOL; HETEROCYCLIC COMPOUND; ISONIAZID; NITRILE OXIDE; PYRIDONE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

1,3 DIPOLAR CYCLOADDITION; ARTICLE; CHEMICAL STRUCTURE; CYCLOADDITION; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 77956648343     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2010.03.054     Document Type: Article

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