Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 24, 1998, Pages 3499-3504

  Xue, Chu Biao ^a   Roderick, John ^a   Mousa, Shaker ^a   Olson, Richard E ^a   DeGrado, William F ^a,b  

^a DUPONT COMPANY   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; FIBRINOGEN RECEPTOR; FIBRINOGEN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; XU 057;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DOSE TIME EFFECT RELATION; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; ORAL DRUG ADMINISTRATION; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; DOGS; HUMANS; ISOXAZOLES; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX;

ANIMALIA; CANIS FAMILIARIS;

EID: 0032535501     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00637-4     Document Type: Article

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18. 18. XU057 or XU065 itself is inactive in the inhibition of platelet aggregation. After intravenous or oral administration to dogs, they were rapidly hydrolyzed to their corresponding carboxylic acids to exhibit the observed inhibition of ADP-induced ex vivo platelet aggregation as shown in Figures 1-3.