Elevated expression of tumor necrosis factor-± signaling molecules in colonic tumors of Zucker obese (fa/fa) rats

International Journal of Cancer

Volumn 127, Issue 9, 2010, Pages 2042-2050

  Jain, Swati S ^a   Bird, Ranjana P ^b  

^a UNIVERSITY OF GUELPH   (Canada)

^b UNIVERSITY OF WINDSOR   (Canada)

Author keywords

colon cancer; NF B; obesity; TNF ; Zucker obese rats

Indexed keywords

AZOXYMETHANE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEPTIN RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; NF KAPPA B KINASE; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER INCIDENCE; CANCER INVASION; CANCER SURVIVAL; CARCINOGENESIS; COLON MUCOSA; COLON TUMOR; CONTROLLED STUDY; FEMALE; INSULIN BLOOD LEVEL; NONHUMAN; ORGAN WEIGHT; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; BLOOD CELL COUNT; CHEMICALLY INDUCED DISORDER; METABOLISM; OBESITY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; ZUCKER RAT;

ANIMALS; AZOXYMETHANE; BLOOD CELL COUNT; COLONIC NEOPLASMS; FEMALE; NF-KAPPA B; OBESITY; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77956646676     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25232     Document Type: Article

References (55)

1. Roncucci L, Stamp D, Medline A, Cullen JB, Bruce WR,. Identification and quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol 1991; 22: 287 -94.
2. Cheng L, Lai MD,. Aberrant crypt foci as microscopic precursors of colorectal cancer. World J Gastroenterol 2003; 9: 2642 -9.
3. Kim Y, Kim Y, Lee S,. An association between colonic adenoma and abdominal obesity: a cross-sectional study. BMC Gastroenterol 2009; 9: 4.
4. Pischon T, Lahmann PH, Boeing H, Friedenreich C, Norat T, Tjonneland A, Halkjaer J, Overvad K, Clavel-Chapelon F, Boutron-Ruault MC, Guernec G, Bergmann MM, et al. Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst 2006; 98: 920 -31.
5. Rapp K, Schroeder J, Klenk J, Stoehr S, Ulmer H, Concin H, Diem G, Oberaigner W, Weiland SK,. Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria. Br J Cancer 2005; 93: 1062 -7.
6. Giovannucci E,. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J Nutr 2001; 131: 3109S -3120S.
7. Gunter MJ, Leitzmann MF,. Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. J Nutr Biochem 2006; 17: 145 -56.
8. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I,. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004; 114: 1752 -61.
9. Komninou D, Ayonote A, Richie JP, Jr, Rigas B,. Insulin resistance and its contribution to colon carcinogenesis. Exp Biol Med (Maywood) 2003; 228: 396 -405.
10. Sonnenberg GE, Krakower GR, Kissebah AH,. A novel pathway to the manifestations of metabolic syndrome. Obes Res 2004; 12: 180 -6.
11. Renehan AG, Roberts DL, Dive C,. Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem 2008; 114: 71 -83.
12. Giovannucci E,. Metabolic syndrome, hyperinsulinemia, and colon cancer: a review. Am J Clin Nutr 2007; 86: s836 -s842.
13. Samad F, Uysal KT, Wiesbrock SM, Pandey M, Hotamisligil GS, Loskutoff DJ,. Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor. Proc Natl Acad Sci USA 1999; 96: 6902 -7.
14. Hotamisligil GS, Shargill NS, Spiegelman BM,. Adipose expression of tumor necrosis factor-±: direct role in obesity-linked insulin resistance. Science 1993; 259: 87 -91.
15. Wajant H, Pfizenmaier K, Scheurich P,. Tumor necrosis factor signaling. Cell Death Differ 2003; 10: 45 -65.
16. Balkwill F,. TNF-± in promotion and progression of cancer. Cancer Metastasis Rev 2006; 25: 409 -16.
17. Anderson GM, Nakada MT, DeWitte M,. Tumor necrosis factor-± in the pathogenesis and treatment of cancer. Curr Opin Pharmacol 2004; 4: 314 -20.
18. Lin A, Karin M,. NF-°B in cancer: a marked target. Semin Cancer Biol 2003; 13: 107 -14.
19. Perkins ND, Gilmore TD,. Good cop, bad cop: the different faces of NF-°B. Cell Death Differ 2006; 13: 759 -72.
20. Hardwick JC, van den Brink GR, Offerhaus GJ, van Deventer SJ, Peppelenbosch MP,. NF-°B, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. Oncogene 2001; 20: 819 -27.
21. Kojima M, Morisaki T, Sasaki N, Nakano K, Mibu R, Tanaka M, Katano M,. Increased nuclear factor-kB activation in human colorectal carcinoma and its correlation with tumor progression. Anticancer Res 2004; 24: 675 -81.
22. Fantini MC, Pallone F,. Cytokines: from gut inflammation to colorectal cancer. Curr Drug Targets 2008; 9: 375 -80.
23. Schutze S, Wiegmann K, Machleidt T, Kronke M,. TNF-induced activation of NF-°B. Immunobiology 1995; 193: 193 -203.
24. Zucker TF, Zucker LM,. Hereditary obesity in the rat associated with high serum fat and cholesterol. Proc Soc Exp Biol Med 1962; 110: 165 -71.
25. Bray GA,. Experimental models for the study of obesity: introductory remarks. Fed Proc 1977; 36: 137 -8.
26. McCaleb ML, Sredy J,. Metabolic abnormalities of the hyperglycemic obese Zucker rat. Metabolism 1992; 41: 522 -5.
27. Raju J, Bird RP,. Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factor and cyclooxygenase isoforms in Zucker obese (fa/fa) rats. Cancer Res 2003; 63: 6595 -601.
28. Bird RP, Yao K, Lasko CM, Good CK,. Inability of low-or high-fat diet to modulate late stages of colon carcinogenesis in Sprague-Dawley rats. Cancer Res 1996; 56: 2896 -9.
29. Kiunga GA, Raju J, Sabljic N, Bajaj G, Good CK, Bird RP,. Elevated insulin receptor protein expression in experimentally induced colonic tumors. Cancer Lett 2004; 211: 145 -53.
30. Raju J, Bird RP,. Alleviation of hepatic steatosis accompanied by modulation of plasma and liver TNF-± levels by Trigonella foenum graecum (fenugreek) seeds in Zucker obese (fa/fa) rats. Int J Obes (Lond) 2006; 30: 1298 -307.
31. Bray GA,. The Zucker-fatty rat: a review. Fed Proc 1977; 36: 148 -53.
32. Ogawa Y, Masuzaki H, Isse N, Okazaki T, Mori K, Shigemoto M, Satoh N, Tamura N, Hosoda K, Yoshimasa Y,. Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest 1995; 96: 1647 -52.
33. Weber RV, Stein DE, Scholes J, Kral JG,. Obesity potentiates AOM-induced colon cancer. Dig Dis Sci 2000; 45: 890 -5.
34. Giovannucci E, Michaud D,. The role of obesity and related metabolic disturbances in cancers of the colon, prostate, and pancreas. Gastroenterology 2007; 132: 2208 -25.
35. Korach-Andre M, Gao J, Gounarides JS, Deacon R, Islam A, Laurent D,. Relationship between visceral adiposity and intramyocellular lipid content in two rat models of insulin resistance. Am J Physiol Endocrinol Metab 2005; 288: E106 -E116.
36. Ruegg C,. Leukocytes, inflammation, and angiogenesis in cancer: fatal attractions. J Leukoc Biol 2006; 80: 682 -4.
37. Porcheray F, Viaud S, Rimaniol AC, Leone C, Samah B, reuddre-Bosquet N, Dormont D, Gras G,. Macrophage activation switching: an asset for the resolution of inflammation. Clin Exp Immunol 2005; 142: 481 -9.
38. Hussein MR,. Tumour-associated macrophages and melanoma tumourigenesis: integrating the complexity. Int J Exp Pathol 2006; 87: 163 -76.
39. Li B, Vincent A, Cates J, Brantley-Sieders DM, Polk DB, Young PP,. Low levels of tumor necrosis factor ± increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res 2009; 69: 338 -48.
40. Nierodzik ML, Karpatkin S,. Thrombin induces tumor growth, metastasis, and angiogenesis: evidence for a thrombin-regulated dormant tumor phenotype. Cancer Cell 2006; 10: 355 -62.
41. Mousa SA,. Role of current and emerging antithrombotics in thrombosis and cancer. Drugs Today (Barc) 2006; 42: 331 -50.
42. Adam JM, Raju J, Khalil N, Bird RP,. Evidence for the involvement of dietary lipids on the modulation of transforming growth factor-1 in the platelets of male rats. Mol Cell Biochem 2000; 211: 145 -52.
43. 2 increases? J Cardiometab Syndr 2008; 3: 30 -4.
44. Sola E, Vaya A, Martinez M, Moscardo A, Corella D, Santaolaria ML, Espana F, Hernandez-Mijares A,. Erythrocyte membrane phosphatidylserine exposure in obesity. Obesity (Silver Spring) 2009; 17: 318 -22.
45. Liu RH, Mizuta M, Kurose T, Matsukura S,. Early events involved in the development of insulin resistance in Zucker fatty rat. Int J Obes Relat Metab Disord 2002; 26: 318 -26.
46. Leonard BL, Watson RN, Loomes KM, Phillips AR, Cooper GJ,. Insulin resistance in the Zucker diabetic fatty rat: a metabolic characterisation of obese and lean phenotypes. Acta Diabetol 2005; 42: 162 -70.
47. Varfolomeev EE, Ashkenazi A,. Tumor necrosis factor: an apoptosis JuNKie? Cell 2004; 116: 491 -7.
48. Rojas-Cartagena C, Flores I, Appleyard CB,. Role of tumor necrosis factor receptors in an animal model of acute colitis. Cytokine 2005; 32: 85 -93.
49. Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D,. Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors. J Exp Med 1992; 175: 323 -9.
50. Higuchi M, Aggarwal BB,. Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation. J Immunol 1994; 152: 4017 -25.
51. Tam WF, Lee LH, Davis L, Sen R,. Cytoplasmic sequestration of rel proteins by I°B± requires CRM1-dependent nuclear export. Mol Cell Biol 2000; 20: 2269 -84.
52. Hayden MS, Ghosh S,. Signaling to NF-°B. Genes Dev 2004; 18: 2195 -224.
53. Remacle-Bonnet MM, Garrouste FL, Heller S, Andre F, Marvaldi JL, Pommier GJ,. Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor ±-induced mitogen-activated protein kinase and nuclear factor °B signaling pathways. Cancer Res 2000; 60: 2007 -17.
54. Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R,. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem 2008; 114: 23 -37.
55. Remacle-Bonnet M, Garrouste F, Baillat G, Andre F, Marvaldi J, Pommier G,. Membrane rafts segregate pro-from anti-apoptotic insulin-like growth factor-I receptor signaling in colon carcinoma cells stimulated by members of the tumor necrosis factor superfamily. Am J Pathol 2005; 167: 761 -73.