The association between ALS and population density: A population based study

Amyotrophic Lateral Sclerosis

Volumn 11, Issue 5, 2010, Pages 435-438

  Scott, Kirsten M ^a   Abhinav, Kumar ^b   Wijesekera, Lokesh ^b   Ganesalingam, Jeban ^b   Goldstein, Laura H ^b   Janssen, Anna ^b   Dougherty, Andrew ^b   Willey, Emma ^b   Stanton, Biba R ^b   Turner, Martin R ^c   Ampong, Mary Ann ^a   Sakel, Mohammed ^e   Orrell, Richard ^d,f   Howard, Robin ^f   Shaw, Christopher E ^b   Nigel Leigh, P ^b   Al Chalabi, Ammar ^b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e EAST KENT HOSPITALS UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^f NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

Author keywords

Amyotrophic lateral sclerosis; Epidemiology; Population density

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION DENSITY; POPULATION STRUCTURE; PRIORITY JOURNAL; RESIDENTIAL CARE; RURAL AREA; RURAL HEALTH CARE; UNITED KINGDOM;

AMYOTROPHIC LATERAL SCLEROSIS; ENGLAND; FEMALE; HUMANS; LONDON; MALE; POPULATION DENSITY; REGISTRIES; RURAL POPULATION; URBAN POPULATION;

EID: 77956644860     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.3109/17482961003754552     Document Type: Article

References (23)

1. Mitchell JD, Borasio GD. Amyotrophic Lateral Sclerosis. Lancet. 2007;369:2031-41.
2. Govoni V, Granieri E, Fallica E, Casetta I. Amyotrophic lateral sclerosis, rural environment and agricultural work in the local health district of Ferrara, Italy, in the years 1964-1998. J Neurol. 2005;252:1322-7.
3. Johnston CA, Stanton BR, Turner MR, Gray R, Blunt AH, Butt D, et al. Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London. J Neurol. 2006;253:1642-3.
4. Logroscino G, Traynor BJ, Hardiman O, Chio A , Couratier P, Mitchell JD, et al. EURALS. Descriptive epidemiology of amyotrophic lateral sclerosis: new evidence and unsolved issues. J Neurol Neurosurg Psychiatry. 2008;79:6-11.
5. Simpson CL, Al-Chalabi A. Amyotrophic lateral sclerosis as a complex genetic disease. Biochim Biophys Acta. 2006;1762: 973-85.
6. Nelson LM, McGuire V, Longstreth WT Jr, Matkin C. Population based case-control study of amyotrophic lateral sclerosis in Western Washington State: cigarette smoking and alcohol consumption. Am J Epidemiol. 2000;151:156-63.
7. Mitchell JD. Amyotrophic lateral sclerosis: toxins and environment. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1:235-50.
8. Mandrioli J, Faglioni P, Merelli E, Sola P. The epidemiology of ALS in Modena, Italy. Neurology. 2003;60:683-9.
9. Chio A, Benzi G, Dossena M, Mutani R, Mora G. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. 2005;128:472-6.
10. Haley RW. Excess incidence of ALS in young Gulf War veterans. Neurology. 2003;61:750-6.
11. Cronin S, Greenway MJ, Prehn JH, Hardiman O. P araoxonase promoter and intronic variants modify risk of sporadic amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry. 2007;78:984-6.
12. Saeed M, Siddique N, Hung WY, Ushacheva E, Liu E, Sufi t RL, et al. Paraoxonase cluster polymorphisms are associated with sporadic ALS. Neurology. 2006;67:771-6.
13. Landers JE, Melki J, Meininger V, Glass JD, van den Berg LH, van Es MA, et al. Reduced expression of the kinesin-associated protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 2009; 106:9004-9.
14. Diekstra FP, Beleza-Meireles A, Leigh NP, Shaw CE, Al-Chalabi A. Interaction between PON1 and population density in amyotrophic lateral sclerosis. Neuroreport. 2009;20:186-90.
15. Wills AM, Cronin S, Slowik A, Kasperaviciute D, van Es MA, Morahan JM, et al. A large scale international metaanalysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology. 2009;73:16-24.
16. Scott KM, Abhinav K, Stanton BR, Johnston C, Turner MR, Ampong MA, et al. Geographical clustering of amyotrophic lateral sclerosis in south-east England: a population study. Neuroepidemiology. 2009;32:81-8.
17. Abhinav K, Stanton B, Johnston C, Hardstaff J, Orrell RW, Howard R, et al. Amyotrophic lateral sclerosis in south-east England: a population based study (South-East England register for Amyotrophic Lateral Sclerosis (SEALS) registry). Neuroepidemiol. 2007;29:44-8.
18. Office of National Statistics. Neighbourhood statistics (online). Available at: http://neighbourhood.statistics.gov.uk/dissemination/. Accessed 17/05/06.
19. Logroscino G, Traynor BJ, Hardiman O, Chiò A, Mitchell D, Swingler RJ, et al. Incidence of amyotrophic lateral sclerosis in Europe. J Neurol Neurosurg Psychiatry. 2009, Aug 25 (Epub ahead of print).
20. Zaldivar T, Gutierrez J, Lara G, Carbonara M, Logroscino G, Hardiman O. Reduced frequency of ALS in an ethnically mixed population: a population based mortality study. Neurology. 2009;72:1640-5.
21. Leone M, Chiò A, Mortara P, Rosso MG, Schiffer D. Motor neuron disease in the province of Turin, Italy, 1971-1980. Acta Neurol Scand. 1983;68:316-27.
22. Armon C. An evidence based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis. Neuroepidemiology. 2003;22: 217-28.
23. Office of National Statistics. Internal migration within the UK by five-year age group and sex, mid-2007 to mid-2008. Available at: http://www.statistics.gov.uk/statbase/Product. asp?vlnk- 15148. Accessed 15/11/09.