Assessment of biocompatibility and initial evaluation of genipin cross-linked elastin-like polypeptides in the treatment of an osteochondral knee defect in rabbits

Acta Biomaterialia

Volumn 6, Issue 6, 2010, Pages 2108-2115

  Hrabchak, Christopher ^a   Rouleau, Jessica ^a   Moss, Isaac ^b   Woodhouse, Kimberly ^c   Akens, Margarete ^d   Bellingham, Catherine ^e   Keeley, Fred ^e   Dennis, Madison ^e   Yee, Albert ^b,d  

^a Elastin Specialties Inc   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c QUEEN S UNIVERSITY   (Canada)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^e HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

Articular cartilage; Cartilage repair; Elastin; Elastin like polypeptide; Osteochodral defect

Indexed keywords

BIOCOMPATIBILITY; BIOMECHANICS; ELASTIN; GLYCOPROTEINS; POLYPEPTIDES; REPAIR; SELF ASSEMBLY; SURFACE DEFECTS; TISSUE REGENERATION;

ARTICULAR CARTILAGES; CARTILAGE REPAIR; CROSS LINKING; DOMAIN STRUCTURE; ELASTIN-LIKE POLYPEPTIDES; GENIPIN; HUMAN ELASTIN; HYDROPHOBICS; OSTEOCHODRAL DEFECT; OSTEOCHONDRAL;

CARTILAGE;

BIOMATERIAL; ELASTIN; GENIPIN; HYALIN; POLYPEPTIDE; TROPOELASTIN; CROSS LINKING REAGENT; IRIDOID; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCOMPATIBILITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; EXON; HISTOPATHOLOGY; IMMUNE RESPONSE; IMPLANT; IMPLANTATION; KNEE INJURY; NONHUMAN; PRIORITY JOURNAL; SYNOVIAL FLUID; WEIGHT BEARING; WOUND HEALING; ANIMAL; CHEMISTRY; DRUG IMPLANT; HARDNESS; MATERIALS TESTING; OSTEOCHONDRITIS; PATHOLOGY; RABBIT; SURFACE PROPERTY; TREATMENT OUTCOME; YOUNG MODULUS;

ORYCTOLAGUS CUNICULUS;

ANIMALS; BIOCOMPATIBLE MATERIALS; CROSS-LINKING REAGENTS; DRUG IMPLANTS; ELASTIC MODULUS; ELASTIN; HARDNESS; IRIDOIDS; MATERIALS TESTING; OSTEOCHONDRITIS; PEPTIDES; RABBITS; SURFACE PROPERTIES; TREATMENT OUTCOME;

EID: 77956644329     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2009.12.034     Document Type: Article

References (37)

1. Beris AE, Lykissas MG, Papageorgiou CD, Georgoulis AD. Advances in articular cartilage repair. Injury 2005;36 S: S14-23.
2. Minas T, Nehrer S. Current concepts in the treatment of articular cartilage defects. Orthopedics 1997;6:525-38.
3. Fritz J, Janssen P, Gaissmaier C. Articular cartilage defects in the knee - basics, therapies and results. Injury 2008;39S1: S50-7.
4. Stoop R. Smart biomaterials for tissue engineering of cartilage. Injury 2008;39S1: S77-87.
5. Yang PJ, Temenoff JS. Engineered orthopedic tissue interfaces. Tissue Eng B 2009;15:127-41.
6. Lu L, Zhu X, Valenzuela RG, Currier BL, Yaszemski MJ. Biodegradable polymer scaffolds for cartilage tissue engineering. Clin Orthop Relat Res 2001;391 S: 251-70.
7. Tan H, Chu CR, Payne KA, Marra KG. Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials 2009;30:2499-506.
8. Park KH, Na K. Effect of growth factors on chondrogenic differentiation of rabbit mesenchymal cells embedded in injectable hydrogels. J Biosci Bioeng 2008;106:74-9.
9. Ratcliffe A. Industrial approaches in tissue engineering. In: Mao J, Vunjak-Novakovic G, Mikos A, Atala A, editors. Translational approaches in tissue engineering and regenerative medicine. London: Artech House; 2008. p. 463-72.
10. Sherwood JK et al. A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials 2002;23:4739-51.
11. Bellingham CM, Woodhouse KA, Robson P, Rothstein SJ, Keeley FW. Selfaggregation characteristics of recombinantly expressed human elastin polypeptides. Biochim Biophys Acta 2001;1550:6-19.
12. Cox BA, Starcher BC, Urry DW. Coacervation of alpha-elastin results in fiber formation. J Biol Chem 1973;317:209-13.
13. Podrazsky V, Jackson DS. Observations on coacervation of soluble elastins. Collection Czech Chem Commun 1976;41:2296-302.
14. Betre H, Setton LA, Meyer DE, Chilkoti A. Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair. Biomacromolecules 2002;3:910-6.
15. Miao M, Bellingham CM, Stahl RK, Sitarz EE, Lane CJ, Keeley FW. Sequence and structure determinants for the self-aggregation of recombinant polypeptides modeled after human elastin. J Biol Chem 2003;278:48553-62.
16. Bellingham CM et al. Recombinant human elastin polypeptides self-assemble into biomaterials with elastin-like properties. Biopolymers 2003;70:445-55.
17. Vieth S, Bellingham CM, Keeley FW, Hodge SM, Rousseau D. Miscrostructural and tensile properties of elastin-based polypeptides crosslinked with genipin and pyrroloquinoline quinone. Biopolymers 2007;85:199-206.
18. Touyama R et al. Studies on the blue pigments produced from genipin and methylamine. II. On the formation of brownish-red intermediates leading to the blue pigment formation. Chem Pharm Bull 1994;42:1571-8. (Pubitemid 24276149)
19. Luginbuehl R, Fluri A. Analysis of endotoxin residues on cleaned implant materials. J ASTM Int 2008;5:1-7.
20. Périé D, Korda D, Iatridis JC. Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability. J Biomech 2005;38:2164-71.
21. Burkitt HG, Young B, Heath JW, editors. Wheater's functional histology: a text and colour atlas. London: Churchill Livingstone; 1993. p. 42-60.
22. Mainil-Varlet P, Rieser F, Grogan S, Mueller W, Saager C, Jakob RP. Articular cartilage repair using a tissue-engineered cartilage-like implant: an animal study. Osteoarthritis Cartilage 2001;9(Suppl. A): S6-S15.
23. O'Driscoll SW, Keeley FW, Salter RB. The chondrogenic potential of free autogenous periosteal grafts for biological resurfacing of major full-thickness defects in joint surfaces under the influence of continuous passive motion. An experimental investigation in the rabbit. J Bone Joint Surg Am 1986;68:1017-35.
24. O'Driscoll SW, Keeley FW, Salter RB. Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. J Bone Joint Surg Am 1998;70:595-606.
25. Mainil-Varlet P et al. Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am 2003;85(Suppl. A): 45-57.
26. McHale MK, Setton LA, Chilkoti A. Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair. Tissue Eng 2005;11:1768-79.
27. Nettles DL et al. In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model. Tissue Eng A 2008;14:1133-40.
28. Woodhouse KA et al. Investigation of recombinant human elastin polypeptides as non-thrombogenic coatings. Biomaterials 2004;25:4543-53.
29. Shapiro F, Koide S, Glimcher MJ. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg Am 1993;75:532-53.
30. Mithieux SM, Tu Y, Korkmaz E, Braet F, Weiss AS. In situ-polymerization of tropoelastin in the absence of chemical cross-linking. Biomaterials 2009;30:431-5.
31. Karageorgiou V, Kaplan D. Porosity of 3D biomaterials and osteogenesis. Biomaterials 2005;26:5474-91.
32. Chevalier X, Groult N, Texier JM, Larget-Piet B, Hornebeck W. Elastase activity in cartilage extract and synovial fluids from subjects with osteoarthritis or rheumatoid arthritis: the prominent role of metalloproteases. Clin Exp Rheumatol 1996;14:235-41.
33. Menninger H et al. Lysosomal elastase: effect on mechanical and biochemical properties of normal cartilage, inhibition by polysulfonated glycosaminoglycan, and binding to chondrocytes. Rheumatol Int 1981;1:73-81.
34. Verbruggen G, Wittoek R, Groeneboer S, Cruyssen BV, Goemaere S, Elewaut D. Osteochondral repair in synovial joints. Curr Opin Rheumatol 2007;19:265-71.
35. Betre H, Ong SR, Guilak F, Chilkoti A, Fermor B, Setton LA. Chondrocyte differentiation of human adipose derived adult stem cells in elastin-like polypeptide. Biomaterials 2006;27:91-9.
36. Hao T et al. The support of matrix accumulation and the promotion of sheep articular cartilage defects repair in vivo by chitosan hydrogels. Osteoarthritis Cartilage 2009 [epub ahead of print].
37. Ding M, Dalstra M, Linde F, Hvid I. Mechanical properties of the normal human tibial cartilage-bone complex in relation to age. Clin Biomech 1998;13:351-8.