The maltose ATP-binding cassette transporter in the 21st century - Towards a structural dynamic perspective on its mode of action: MicroReview

Molecular Microbiology

Volumn 77, Issue 6, 2010, Pages 1354-1366

  Bordignon, Enrica ^a   Grote, Mathias ^b,c   Schneider, Erwin ^b  

^a ETH ZURICH   (Switzerland)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; MALTODEXTRIN; MALTOSE; MALTOSE BINDING PROTEIN K; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARCHAEOGLOBUS FULGIDUS; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; ESCHERICHIA COLI; HYDROLYSIS; METHANOSARCINA; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW;

ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MALTOSE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PERIPLASMIC BINDING PROTEINS; PROTEIN STRUCTURE, TERTIARY; SALMONELLA ENTERICA;

ESCHERICHIA;

EID: 77956636052     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2010.07319.x     Document Type: Review

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81. Zou, P. Mchaourab, H.S. (2010) Increased sensitivity and extended range of distance measurements in spin-labeled membrane proteins: Q-band double electron-electron resonance and nanoscale bilayers. Biophys J 98: L18 L20. Passage of maltose (at molar concentrations) and maltodextrins across the outer membrane requires a genetically linked specific maltoporin, a trimeric ß-barrel protein, which is not subject of this article. See Ranquin and van Gelder (2004) for review. The vitamin B12 type II transporter, for which a distinct mechanism of action was suggested, has also been crystallized in two states (absence and presence of BtuF), one of which might correlate with the resting state. However, no structure with bound nucleotides is currently available (Locher et al., 2002 ; Hollenstein et al., 2007). In this review, the term apo-state is preferred to the term 'resting state' for the complex in the absence of nucleotides. In fact, the 'resting state' of the transporter in vivo can be considered to be ATP-bound, due to the high ATP concentrations inside the cell.