Adrenocortical response in infants undergoing cardiac surgery with cardiopulmonary bypass and circulatory arrest*

Pediatric Critical Care Medicine

Volumn 11, Issue 1, 2010, Pages 44-51

  Gajarski, Robert J ^a   Stefanelli, Christopher B ^a   Graziano, Joseph N ^a   Kaciroti, Niko ^c   Charpie, John R ^a   Vazquez, Delia ^b,c  

^a Divisions of Cardiology

^b Department of Endocrinology ^*

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Adrenocortical response; Adrenocorticotropic hormone; Cardiopulmonary bypass; Cortisol; Infant

Indexed keywords

ALDOSTERONE; CORTICOTROPIN; HYDROCORTISONE; STEROID; TETRACOSACTIDE;

ADRENAL CORTEX; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL TRIAL; CONGENITAL HEART DISEASE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP HYPOTHERMIC CIRCULATORY ARREST; FEMALE; FOLLOW UP; HEART ARREST; HEART SURGERY; HORMONE DETERMINATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFANT; INOTROPISM; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PILOT STUDY; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCORING SYSTEM; STRESS; TERTIARY HEALTH CARE;

EID: 75149123546     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181a64743     Document Type: Article

References (22)

1. Bourchier D, Weston PJ: Randomized trial of dopamine compared with hydrocortisone for the treatment of hypotensive very low birthweight infants. Arch Dis Child 1997; 76: 174F-178F
2. Gaissmaier R, Pohlandt F: Single-dose dexamethasone treatment of hypotension in preterm infants. J Pediatr 1999; 134:701-705
3. Scott SM, Watterberg KL: Effect of gestational age, postnatal age and illness on plasma cortisol concentrations in premature infants. Pediatr Res 1995; 37:112-116
4. Tantivit P, Subramanian J, Garg M, et al: Low serum cortisol in term infants with refractory hypotension. J Perinatol 1999; 19: 352-357
5. Hatherill M, Tibby SM, Hilliard T, et al: Adrenal insufficiency in septic shock. Arch Dis Child 1999; 80:51-55
6. Wypij D, Newburger JW, Rappaport LA, et al: The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: The Boston Circulatory Arrest Trial. J Thorac Cardiovasc Surg 2003; 126:1397-1403
7. Ririe DG, Butterworth JF, Hines M, et al: Effects of cardiopulmonary bypass and deep hypothermic circulatory arrest on the thyroid axis during and after repair of congenital heart defects: Preservation by deep hypothermia? Anesth Analg 1998; 87:543-548
8. Oates RK, Simpson JM, Turnbull JA, et al: The relationship between intelligence and duration of circulatory arrest with deep hypothermia. J Thorac Cardiovasc Surg 1995; 110:786-792
9. Newburger JW, Jonas RA, Wernovsky G, et al: A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. N Engl J Med 1993; 329: 1057-1064
10. Wernovsky G, Wypij D, Jonas RA, et al: Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. Circulation 1995; 92:2226-2235
11. Dönmez A, Kaya H, Haberal A, et al: The effect of etomidate induction on plasma cortisol levels in children undergoing cardiac surgery. J Cardiothorac Vasc Anesth 1998; 12:182-185
12. Flezzani P, Croughwell ND, McIntyre RW, et al: Isoflurane decreases the cortisol response to cardiopulmonary bypass. Anesth Analg 1986; 65:1117-1122
13. Heckmann M, Wudy SA, Haack D, et al: Serum cortisol concentrations in ill preterm infants less than 30 weeks gestational age. Acta Paediatr 2000; 89:1098-1103
14. Ng PC, Lam CWK, Fok TF, et al: Refractory hypotension in preterm infants with adrenocortical insufficiency. Arch Dis Child Fetal Neonatal Ed 2001; 84:F122-F124
15. Shore S, Nelson DP, Pearl JM, et al: Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease. Am J Cardiol 2001; 88:591-594
16. Ando M, Park IS, Wada N, et al: Steroid supplementation: A legitimate pharmacotherapy after neonatal open heart surgery. Ann Thorac Surg 2005; 80:1672-1678
17. Anand KJS, Hansen DD, Hickey PR: Hormonal-metabolic stress responses in neonates undergoing cardiac surgery. Anesthesiology 1990; 73:661-670
18. Roth-Isigkeit AK, Schmucker P: Postoperative dissociation of blood levels of cortisol and adrenocorticotropin after coronary artery bypass grafting surgery. Steroids 1997; 62:695-699
19. Pollock EMM, Pollock JCS, Jamieson MPG, et al: Adrenocortical hormone concentrations in children during cardiopulmonary bypass with and without pulsatile flow. Br J Anaesth 1988; 60:536-541
20. New I, Del Balzo P, Crawford C, et al: The adrenal cortex. In: Clinical Pediatric Endocrinology. Kaplan S (Ed). Philadelphia, WB Saunders, 1990, p 216
21. Lamberts SWJ, Bruining HA, De Jong FH: Corticosteroid therapy in severe illness. N Engl J Med 1997; 337:1285-1292
22. Simsic JM, Cuadrado A, Kirshborn PM, et al: Risk adjustment for congenital heart surgery (RACHS): Is it useful in a single-center series of newborns as a predictor of outcome in a high-risk population? Congenit Heart Dis 2006; 1:148-151