Purine analogs sensitize the multidrug resistant cell line (NCI-H460/R) to doxorubicin and stimulate the cell growth inhibitory effect of verapamil

Investigational New Drugs

Volumn 28, Issue 4, 2010, Pages 482-492

  Pešić, Milica ^a   Podolski, Ana ^a   Rakić, Ljubiša ^b   Ruždijić, Sabera ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b SERBIAN ACADEMY OF SCIENCES AND ARTS   (Serbia)

Author keywords

8 Cl cAMP; Doxorubicin; Drug combination; Multidrug resistance; Sulfinosine; Verapamil

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE; DOXORUBICIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; SULFINOSINE; VERAPAMIL; 8 BROMO CYCLIC AMP; 8 CHLORO CYCLIC ADENOSINE MONOPHOSPHATE; 8-CHLORO-CYCLIC ADENOSINE MONOPHOSPHATE; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; DRUG DERIVATIVE; GLYCOPROTEIN P; GROWTH INHIBITOR; PURINE NUCLEOSIDE;

ARTICLE; CANCER CELL; CELL GROWTH; CHEMOSENSITIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; DOSE RESPONSE; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; METABOLISM; TUMOR CELL LINE;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CALCIUM CHANNEL BLOCKERS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; GROWTH INHIBITORS; HUMANS; P-GLYCOPROTEIN; PURINE NUCLEOSIDES; VERAPAMIL;

EID: 77956632815     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-009-9277-x     Document Type: Article

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