Synthesis and in vitro evaluation of imidazo[1,2- b ]pyridazines as ligands for β-amyloid plaques

ACS Medicinal Chemistry Letters

Volumn 1, Issue 2, 2010, Pages 80-84

  Zeng, Fanxing ^a   Alagille, David ^b   Tamagnan, Gilles D ^b   Ciliax, Brian J ^a   Levey, Allan I ^a   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Inst for Neurodeg Disorders   (United States)

Author keywords

amyloid plaque; Imidazo 1,2 b pyridazine; positron emission tomography; structure activity relationship

Indexed keywords

2 (4' DIMETHYLAMINOPHENYL) 6 (METHYLTHIO)IMIDAZO[1,2 B]PYRIDAZINE; 2 (4' DIMETHYLAMINOPHENYL) 6 IODOIMIDAZO[1,2 A]PYRIDINE; AMYLOID BETA PROTEIN[1-40]; PITTSBURGH COMPOUND B; PYRIDAZINE DERIVATIVE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN AGGREGATION; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 77956631488     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100005j     Document Type: Article

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