System biology analysis of cell cycle pathway involved in hepatocellular carcinoma

Frontiers in Bioscience - Scholar

Volumn 2 S, Issue 3, 2010, Pages 1127-1144

  Sun, Meiqian ^a   Mo, Wenjuan ^a   Fu, Xuping ^a   Wu, Gang ^a   Huang, Yan ^a   Tang, Rong ^a   Guo, Yi ^a   Qiu, Minyan ^b   Zhao, Feng ^c   Li, Lin ^d   Huang, Shengdong ^c   Mao, Yumin ^a   Li, Yao ^a   Xie, Yi ^a  

^a FUDAN UNIVERSITY   (China)

^b BioStar Genechip Incorporated   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

CCNB1; Cell cycle pathway; Expression profile; Genetic algorithm; Genetic network; Hepatocellular carcinoma; MCM2; Microarray; RNA interference; Structural equation modeling

Indexed keywords

CCNB1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN B1; MCM2 PROTEIN, HUMAN; NUCLEAR PROTEIN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; BIOLOGICAL MODEL; CELL CYCLE; DRUG ANTAGONISM; GENE EXPRESSION; GENE REGULATORY NETWORK; GENETICS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; NUCLEOTIDE SEQUENCE; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SYSTEMS BIOLOGY; TUMOR CELL LINE;

APOPTOSIS; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CYCLIN B1; GENE EXPRESSION; GENE REGULATORY NETWORKS; HUMANS; LIVER NEOPLASMS; MODELS, GENETIC; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SYSTEMS BIOLOGY;

EID: 77956629136     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: None     Document Type: Article

References (91)

1. A. I. Gomaa, S. A. Khan, M. B. Toledano, I. Waked and S. D. Taylor-Robinson: Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis. World J Gastroenterol, 14(27), 4300-8 (2008)
2. J. M. Llovet, A. Burroughs and J. Bruix: Hepatocellular carcinoma. Lancet, 362(9399), 1907-17 (2003) (Pubitemid 37518510)
3. D. M. Parkin, F. Bray, J. Ferlay and P. Pisani: Estimating the world cancer burden: Globocan 2000. Int J Cancer, 94(2), 153-6 (2001) (Pubitemid 32911406)
4. G. Montalto, M. Cervello, L. Giannitrapani, F. Dantona, A. Terranova and L. A. Castagnetta: Epidemiology, risk factors, and natural history of hepatocellular carcinoma. Ann N Y Acad Sci, 963, 13-20 (2002) (Pubitemid 34721691)
5. A. M. Di Bisceglie: Epidemiology and clinical presentation of hepatocellular carcinoma. J Vasc Interv Radiol, 13(9 Pt 2), S169-71 (2002)
6. H. B. El-Serag and A. C. Mason: Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med, 340(10), 745-50 (1999) (Pubitemid 29114292)
7. S. A. Khan, S. D. Taylor-Robinson, M. B. Toledano, A. Beck, P. Elliott and H. C. Thomas: Changing international trends in mortality rates for liver, biliary and pancreatic tumours. J Hepatol, 37(6), 806-13 (2002) (Pubitemid 35404220)
8. S. Parikh and D. Hyman: Hepatocellular cancer: a guide for the internist. Am J Med, 120(3), 194-202 (2007) (Pubitemid 46341174)
9. M. Schwartz, S. Roayaie and M. Konstadoulakis: Strategies for the management of hepatocellular carcinoma. Nat Clin Pract Oncol, 4(7), 424-32 (2007) (Pubitemid 47039693)
10. H. B. El-Serag and K. L. Rudolph: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132(7), 2557-76 (2007) (Pubitemid 46890874)
11. D. M. Parkin, F. Bray, J. Ferlay and P. Pisani: Global cancer statistics, 2002. CA Cancer J Clin, 55(2), 74-108 (2005) (Pubitemid 40372904)
12. X. W. Wang, S. P. Hussain, T. I. Huo, C. G. Wu, M. Forgues, L. J. Hofseth, C. Brechot and C. C. Harris: Molecular pathogenesis of human hepatocellular carcinoma. Toxicology, 181-182, 43-7 (2002) (Pubitemid 36015671)
13. S. S. Thorgeirsson and J. W. Grisham: Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet, 31(4), 339-46 (2002) (Pubitemid 35154440)
14. M. A. Feitelson, B. Sun, N. L. Satiroglu Tufan, J. Liu, J. Pan and Z. Lian: Genetic mechanisms of hepatocarcinogenesis. Oncogene, 21(16), 2593-604 (2002) (Pubitemid 34438112)
15. L. Zhao, L. X. Qin, Q. H. Ye, X. Q. Zhu, H. Zhang, X. Wu, J. Chen, Y. K. Liu and Z. Y. Tang: KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma - a functional analysis. J Cancer Res Clin Oncol, 130(12), 719-27 (2004)
16. L. Wilkens, M. Bredt, P. Flemming, S. Kubicka, J. Klempnauer and H. Kreipe: Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization. Am J Clin Pathol, 114(6), 867-74 (2000) (Pubitemid 33051886)
17. M. A. Collonge-Rame, S. Bresson-Hadni, S. Koch, J. P. Carbillet, O. Blagosklonova, G. Mantion, J. P. Miguet, B. Heyd and J. L. Bresson: Pattern of chromosomal imbalances in non-B virus related hepatocellular carcinoma detected by comparative genomic hybridization. Cancer Genet Cytogenet, 127(1), 49-52 (2001) (Pubitemid 32530093)
18. S. Satoh, Y. Daigo, Y. Furukawa, T. Kato, N. Miwa, T. Nishiwaki, T. Kawasoe, H. Ishiguro, M. Fujita, T. Tokino, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, Y. Yamaoka and Y. Nakamura: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nat Genet, 24(3), 245-50 (2000) (Pubitemid 30132191)
19. Y. Chen and Q. Kong: Evaluation of centrosome abnormalities and p53 inactivation in chemical induced hepatocellular carcinogenesis. Neoplasma, 56(2), 169-76 (2009)
20. Y. H. Lee, B. K. Oh, J. E. Yoo, S. M. Yoon, J. Choi, K. S. Kim and Y. N. Park: Chromosomal instability, telomere shortening, and inactivation of p21(WAF1/CIP1) in dysplastic nodules of hepatitis B virus-associated multistep hepatocarcinogenesis. Mod Pathol, 22(8), 1121-31 (2009)
21. Z. Wang, M. Wang, S. Kar and B. I. Carr: Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition. J Cell Physiol, 221(1), 213-20 (2009)
22. K. Tsukiyama-Kohara, S. Tone, I. Maruyama, K. Inoue, A. Katsume, H. Nuriya, H. Ohmori, J. Ohkawa, K. Taira, Y. Hoshikawa, F. Shibasaki, M. Reth, Y. Minatogawa and M. Kohara: Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells. J Biol Chem, 279(15), 14531-41 (2004) (Pubitemid 38618840)
23. T. Masaki, Y. Shiratori, W. Rengifo, K. Igarashi, K. Matsumoto, M. Nishioka, Y. Hatanaka and M. Omata: Hepatocellular carcinoma cell cycle: study of Long-Evans cinnamon rats. Hepatology, 32(4 Pt 1), 711-20 (2000)
24. S. Tommasi, R. Pinto, B. Pilato and A. Paradiso: Molecular pathways and related target therapies in liver carcinoma. Curr Pharm Des, 13(32), 3279-87 (2007) (Pubitemid 350201682)
25. A. Spaziani, A. Alisi, D. Sanna and C. Balsano: Role of p38 MAPK and RNA-dependent protein kinase (PKR) in hepatitis C virus core-dependent nuclear delocalization of cyclin B1. J Biol Chem, 281(16), 10983-9 (2006) (Pubitemid 43855521)
26. A. M. Hui, M. Makuuchi and X. Li: Cell cycle regulators and human hepatocarcinogenesis. Hepatogastroenterology, 45(23), 1635-42 (1998) (Pubitemid 28515174)
27. Z. Wang, S. Kar and B. I. Carr: Cdc25A protein phosphatase: a therapeutic target for liver cancer therapies. Anticancer Agents Med Chem, 8(8), 863-71 (2008)
28. T. Z. Liu, C. Y. Chen, S. J. Yiin, C. H. Chen, J. T. Cheng, M. K. Shih, Y. S. Wang and C. L. Chern: Molecular mechanism of cell cycle blockage of hepatoma SK-Hep-1 cells by Epimedin C through suppression of mitogen-activated protein kinase activation and increased expression of CDK inhibitors p21(Cip1) and p27(Kip1). Food Chem Toxicol, 44(2), 227-35 (2006)
29. Y. Tsukada, T. Tanaka, K. Miyazawa and N. Kitamura: Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2. J Biochem, 136(5), 701-9 (2004) (Pubitemid 40364194)
30. Z. Tian, J. Shen, A. P. Moseman, Q. Yang, J. Yang, P. Xiao, E. Wu and I. S. Kohane: Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer, 122(1), 31-8 (2008) (Pubitemid 350209975)
31. J. Han, Y. Tsukada, E. Hara, N. Kitamura and T. Tanaka: Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells. J Biol Chem, 280(36), 31548-56 (2005) (Pubitemid 41291898)
32. M. T. Laub, H. H. McAdams, T. Feldblyum, C. M. Fraser and L. Shapiro: Global analysis of the genetic network controlling a bacterial cell cycle. Science, 290(5499), 2144-8 (2000) (Pubitemid 32001594)
33. H. Kitano: Systems biology: a brief overview. Science, 295(5560), 1662-4 (2002) (Pubitemid 34202893)
34. X. Gao, X. Fu, T. Li, J. Zi, Y. Luo, Q. Wei, E. Zeng, Y. Xie, Y. Li and Y. Mao: Determining a detectable threshold of signal intensity in cDNA microarray based on accumulated distribution. J Biochem Mol Biol, 36(6), 558-64 (2003) (Pubitemid 38142679)
35. J. J. Hornberg, F. J. Bruggeman, H. V. Westerhoff and J. Lankelma: Cancer: a Systems Biology disease. Biosystems, 83(2-3), 81-90 (2006) (Pubitemid 43199809)
36. T. E. Pronk, A. D. Pimentel, M. Roos and T. M. Breit: Taking the example of computer systems engineering for the analysis of biological cell systems. Biosystems, 90(3), 623-35 (2007) (Pubitemid 350026178)
37. M. Gheorghe, N. Krasnogor and M. Camara: P systems applications to systems biology. Biosystems, 91(3), 435-7 (2008) (Pubitemid 351217086)
38. M. Xiong, J. Li and X. Fang: Identification of genetic networks. Genetics, 166(2), 1037-52 (2004) (Pubitemid 38391760)
39. M. Xiong, C. A. Feghali-Bostwick, F. C. Arnett and X. Zhou: A systems biology approach to genetic studies of complex diseases. FEBS Lett, 579(24), 5325-32 (2005) (Pubitemid 41395151)
40. M. Ronen, R. Rosenberg, B. I. Shraiman and U. Alon: Assigning numbers to the arrows: parameterizing a gene regulation network by using accurate expression kinetics. Proc Natl Acad Sci U S A, 99(16), 10555-60 (2002)
41. T. S. Gardner, D. di Bernardo, D. Lorenz and J. J. Collins: Inferring genetic networks and identifying compound mode of action via expression profiling. Science, 301(5629), 102-5 (2003) (Pubitemid 36801571)
42. S. Datta: Exploring relationships: a partial least square approach. Gene, Exp. 9, 257-264 (2001)
43. M. Schena, D. Shalon, R. W. Davis and P. O. Brown: Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science, 270(5235), 467-70 (1995)
44. Q. H. Ye, L. X. Qin, M. Forgues, P. He, J. W. Kim, A. C. Peng, R. Simon, Y. Li, A. I. Robles, Y. Chen, Z. C. Ma, Z. Q. Wu, S. L. Ye, Y. K. Liu, Z. Y. Tang and X. W. Wang: Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med, 9(4), 416-23 (2003) (Pubitemid 36460075)
45. Q. Wei, Y. Li, L. Chen, L. Zhang, X. He, X. Fu, K. Ying, J. Huang, Q. Chen, Y. Xie and Y. Mao: Genes differentially expressed in responsive and refractory acute leukemia. Front Biosci, 11, 977-82 (2006) (Pubitemid 43253452)
46. Y. Li, Y. Li, R. Tang, H. Xu, M. Qiu, Q. Chen, J. Chen, Z. Fu, K. Ying, Y. Xie and Y. Mao: Discovery and analysis of hepatocellular carcinoma genes using cDNA microarrays. J Cancer Res Clin Oncol, 128(7), 369-79 (2002) (Pubitemid 34824179)
47. F. W. Wamunyokoli, T. Bonome, J. Y. Lee, C. M. Feltmate, W. R. Welch, M. Radonovich, C. Pise-Masison, J. Brady, K. Hao, R. S. Berkowitz, S. Mok and M. J. Birrer: Expression profiling of mucinous tumors of the ovary identifies genes of clinicopathologic importance. Clin Cancer Res, 12(3 Pt 1), 690-700 (2006) (Pubitemid 43259847)
48. H. Huang, S. Colella, M. Kurrer, Y. Yonekawa, P. Kleihues and H. Ohgaki: Gene expression profiling of lowgrade diffuse astrocytomas by cDNA arrays. Cancer Res, 60(24), 6868-74 (2000) (Pubitemid 32059155)
49. A. M. Dring, F. E. Davies, J. A. Fenton, P. L. Roddam, K. Scott, D. Gonzalez, S. Rollinson, A. C. Rawstron, K. S. Rees-Unwin, C. Li, N. C. Munshi, K. C. Anderson and G. J. Morgan: A global expression-based analysis of the consequences of the t(4;14) translocation in myeloma. Clin Cancer Res, 10(17), 5692-701 (2004) (Pubitemid 39180944)
50. H. L. Jia, Q. H. Ye, L. X. Qin, A. Budhu, M. Forgues, Y. Chen, Y. K. Liu, H. C. Sun, L. Wang, H. Z. Lu, F. Shen, Z. Y. Tang and X. W. Wang: Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. Clin Cancer Res, 13(4), 1133-9 (2007) (Pubitemid 46424052)
51. M. J. Callahan, Z. Nagymanyoki, T. Bonome, M. E. Johnson, B. Litkouhi, E. H. Sullivan, M. S. Hirsch, U. A. Matulonis, J. Liu, M. J. Birrer, R. S. Berkowitz and S. C. Mok: Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer. Clin Cancer Res, 14(23), 7667-73 (2008)
52. T. Bonome, D. A. Levine, J. Shih, M. Randonovich, C. A. Pise-Masison, F. Bogomolniy, L. Ozbun, J. Brady, J. C. Barrett, J. Boyd and M. J. Birrer: A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res, 68(13), 5478-86 (2008)
53. H. Okabe, S. Satoh, T. Kato, O. Kitahara, R. Yanagawa, Y. Yamaoka, T. Tsunoda, Y. Furukawa and Y. Nakamura: Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res, 61(5), 2129-37 (2001) (Pubitemid 32692038)
54. Y. Shirota, S. Kaneko, M. Honda, H. F. Kawai and K. Kobayashi: Identification of differentially expressed genes in hepatocellular carcinoma with cDNA microarrays. Hepatology, 33(4), 832-40 (2001) (Pubitemid 32246632)
55. J. J. Crawley and K. A. Furge: Identification of frequent cytogenetic aberrations in hepatocellular carcinoma using gene-expression microarray data. Genome Biol, 3(12), RESEARCH0075 (2002)
56. N. Iizuka, M. Oka, H. Yamada-Okabe, M. Nishida, Y. Maeda, N. Mori, T. Takao, T. Tamesa, A. Tangoku, H. Tabuchi, K. Hamada, H. Nakayama, H. Ishitsuka, T. Miyamoto, A. Hirabayashi, S. Uchimura and Y. Hamamoto: Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet, 361(9361), 923-9 (2003) (Pubitemid 36332108)
57. Q. Pan, L. W. Bao, C. G. Kleer, M. S. Sabel, K. A. Griffith, T. N. Teknos and S. D. Merajver: Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Res, 65(18), 8366-71 (2005) (Pubitemid 41330602)
58. S. Hayama, Y. Daigo, T. Kato, N. Ishikawa, T. Yamabuki, M. Miyamoto, T. Ito, E. Tsuchiya, S. Kondo and Y. Nakamura: Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis. Cancer Res, 66(21), 10339-48 (2006) (Pubitemid 44799753)
59. S. Ashida, H. Nakagawa, T. Katagiri, M. Furihata, M. Iiizumi, Y. Anazawa, T. Tsunoda, R. Takata, K. Kasahara, T. Miki, T. Fujioka, T. Shuin and Y. Nakamura: Molecular features of the transition from prostatic intraepithelial neoplasia (PIN) to prostate cancer: genome-wide geneexpression profiles of prostate cancers and PINs. Cancer Res, 64(17), 5963-72 (2004) (Pubitemid 39129392)
60. G. K. Abou-Alfa: Hepatocellular carcinoma: molecular biology and therapy. Semin Oncol, 33(6 Suppl 11), S79-83 (2006)
61. H. A. Edmondson and P. E. Steiner: Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer, 7(3), 462-503 (1954)
62. M. K. Kerr, M. Martin and G. A. Churchill: Analysis of variance for gene expression microarray data. J Comput Biol, 7(6), 819-37 (2000)
63. J. Aubert, A. Bar-Hen, J. J. Daudin and S. Robin: Determination of the differentially expressed genes in microarray experiments using local FDR. BMC Bioinformatics, 5, 125 (2004)
64. K. D. Dahlquist, N. Salomonis, K. Vranizan, S. C. Lawlor and B. R. Conklin: GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet, 31(1), 19-20 (2002)
65. M. Ashburner, C. A. Ball, J. A. Blake, D. Botstein, H. Butler, J. M. Cherry, A. P. Davis, K. Dolinski, S. S. Dwight, J. T. Eppig, M. A. Harris, D. P. Hill, L. Issel-Tarver, A. Kasarskis, S. Lewis, J. C. Matese, J. E. Richardson, M. Ringwald, G. M. Rubin and G. Sherlock: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet, 25(1), 25-9 (2000) (Pubitemid 30257031)
66. D. A. Hosack, G. Dennis Jr., B. T. Sherman, H. C. Lane and R. A. Lempicki: Identifying biological themes within lists of genes with EASE. Genome Biol, 4(10), R70 (2003)
67. A. Reiner, D. Yekutieli and Y. Benjamini: Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics, 19(3), 368-75 (2003) (Pubitemid 36284936)
68. K. A. Bollen: Structural Equations with Latent Variables. John Wiley & Sons Publishing Company, New York, USA. (1989)
69. P. P. B. Eggermont, LaRiccia, V. N.: Maximum penalized likelihood estimation. Springer, New York, USA. (2001)
70. K. G. Joreskog: Structure analysis of covarlance and correlation matrices. Psychometrika, 43, 443-477 (1978)
71. D. E. Goldberg: Genetic Algorithms in Search, Optimization and Machine Learning. Addison-Wesley Longman Publishing Co., Inc. Boston, MA, USA (1989)
72. Z. Y. Mao, Song, B. W., Li, Z., Hu, H. B.: Optimization method of maximum likelihood estimation parameter estimation based on genetic algorithms. Jounal of Mechanical Strength, 28(1), 079-082 (2006)
73. W. Jiang, D. McDonald, T. J. Hope and T. Hunter: Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. Embo J, 18(20), 5703-13 (1999) (Pubitemid 29486388)
74. W. H. Cho, Y. J. Lee, S. I. Kong, J. Hurwitz and J. K. Lee: CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein. Proc Natl Acad Sci U S A, 103(31), 11521-6 (2006) (Pubitemid 44182484)
75. D. Maiorano, M. Lutzmann and M. Mechali: MCM proteins and DNA replication. Curr Opin Cell Biol, 18(2), 130-6 (2006) (Pubitemid 43375879)
76. S. E. Kearsey and K. Labib: MCM proteins: evolution, properties, and role in DNA replication. Biochim Biophys Acta, 1398(2), 113-36 (1998) (Pubitemid 28305206)
77. G. Maga and U. Hubscher: Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci, 116 (Pt 15), 3051-60 (2003) (Pubitemid 37038954)
78. Y. Xiong, H. Zhang and D. Beach: D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell, 71(3), 505-14 (1992)
79. M. L. Whitfield, G. Sherlock, A. J. Saldanha, J. I. Murray, C. A. Ball, K. E. Alexander, J. C. Matese, C. M. Perou, M. M. Hurt, P. O. Brown and D. Botstein: Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell, 13(6), 1977-2000 (2002) (Pubitemid 34651487)
80. M. A. Gonzalez, S. E. Pinder, G. Callagy, S. L. Vowler, L. S. Morris, K. Bird, J. A. Bell, R. A. Laskey and N. Coleman: Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol, 21(23), 4306-13 (2003) (Pubitemid 46628462)
81. E. C. Obermann, P. Went, A. C. Pehrs, A. Tzankov, P. J. Wild, S. Pileri, F. Hofstaedter and S. Dirnhofer: Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. Oncol Rep, 14(6), 1461-7 (2005)
82. L. X. Qin and Z. Y. Tang: The prognostic molecular markers in hepatocellular carcinoma. World J Gastroenterol, 8(3), 385-92 (2002)
83. S. H. Peng, J. F. Yang, P. P. Xie, H. Deng, H. Li and D. Y. Feng: [Expression of cyclins in hepatocellular carcinoma and its correlation to tumor cell apoptosis]. Ai Zheng, 24(6), 695-8 (2005)
84. J. Yuan, A. Kramer, Y. Matthess, R. Yan, B. Spankuch, R. Gatje, R. Knecht, M. Kaufmann and K. Strebhardt: Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo. Oncogene, 25(12), 1753-62 (2006)
85. J. Yuan, R. Yan, A. Kramer, F. Eckerdt, M. Roller, M. Kaufmann and K. Strebhardt: Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells. Oncogene, 23(34), 5843-52 (2004) (Pubitemid 39093030)
86. D. Feng, Z. Tu, W. Wu and C. Liang: Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer Res, 63(21), 7356-64 (2003) (Pubitemid 37413477)
87. J. J. Blow and A. Dutta: Preventing re-replication of chromosomal DNA. Nat Rev Mol Cell Biol, 6(6), 476-86 (2005) (Pubitemid 40780559)
88. J. M. Bailis and S. L. Forsburg: MCM proteins: DNA damage, mutagenesis and repair. Curr Opin Genet Dev, 14(1), 17-21 (2004) (Pubitemid 38167473)
89. J. Pines and T. Hunter: Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell, 58(5), 833-46 (1989) (Pubitemid 19227894)
90. N. Ramachandran, E. Hainsworth, B. Bhullar, S. Eisenstein, B. Rosen, A. Y. Lau, J. C. Walter and J. LaBaer: Self-assembling protein microarrays. Science, 305(5680), 86-90 (2004) (Pubitemid 38869377)
91. M. Fujita, C. Yamada, T. Tsurumi, F. Hanaoka, K. Matsuzawa and M. Inagaki: Cell cycle- and chromatin binding state-dependent phosphorylation of human MCM heterohexameric complexes. A role for cdc2 kinase. J Biol Chem, 273(27), 17095-101 (1998) (Pubitemid 28311744)