Role of protein kinase C in pitavastatin-induced human paraoxonase i expression in Huh7 cells

Metabolism: Clinical and Experimental

Volumn 59, Issue 9, 2010, Pages 1287-1293

  Arii, Kaoru ^a   Suehiro, Tadashi ^a   Ikeda, Yukio ^a   Kumon, Yoshitaka ^a   Inoue, Mari ^a   Inada, Syojiro ^a   Takata, Hiroshi ^a   Ishibashi, Ayako ^a   Hashimoto, Kozo ^a   Terada, Yoshio ^a  

^a KOCHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ARYLDIALKYLPHOSPHATASE 1; BISINDOLYLMALEIMIDE; CALPHOSTIN C; PITAVASTATIN; PROTEIN KINASE C; TRANSCRIPTION FACTOR SP1; ARYLDIALKYLPHOSPHATASE; BISINDOLYLMALEIMIDE I; BISINDOLYLMALEIMIDE IX; IMMUNOGLOBULIN; INDOLE DERIVATIVE; ISOENZYME; MALEIMIDE DERIVATIVE; QUINOLINE DERIVATIVE; SP1 ANTIGEN;

ARTICLE; BINDING AFFINITY; CELL STRAIN; CELL STRAIN HUH7; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; WESTERN BLOTTING; ANALYSIS OF VARIANCE; CELL CULTURE; CELL LINE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM;

ANALYSIS OF VARIANCE; ARYLDIALKYLPHOSPHATASE; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULINS; INDOLES; ISOENZYMES; MALEIMIDES; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; QUINOLINES; TRANSFECTION;

EID: 77956626873     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.12.003     Document Type: Article

References (34)

1. La Du B.N. Human serum paraoxonase/arylesterase W. Kalow, Pharmacogenetics of drug metabolism 1992 Pergamon Press New York 51 91
2. Blatter M.C., James R.W., and Messmer S. Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase Eur J Biochem 211 1993 871 879
3. Navab M., Hama S.Y., and Hough G.P. High density associated enzymes: their role in vascular biology Curr Opin Lipidol 9 1998 449 456
4. Mackness M.I., Arrol S., and Abbott C. Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase Atherosclerosis 104 1993 129 135
5. Mackness M.I., Durrington P.N., and Mackness B. How high-density lipoprotein protects against the effects of lipid peroxidation Curr Opin Lipidol 11 2000 383 388
6. Shih D.M., Gu L., and Xia Y.R. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis Nature 394 1998 284 287
7. Tward A., Xia Y.R., and Wang X.P. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice Circulation 106 2002 484 490
8. Mackness B., Durrington P., and McElduff P. Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study Circulation 107 2003 2775 2779
9. Ikeda Y., Suehiro T., and Itahara Y. Human serum paraoxonase concentration predicts cardiovascular mortality in hemodialysis patients Clin Nephr 67 2007 358 365
10. West of Scotland Coronary Prevention Study Group Influence of pravastatin and plasma lipids of clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS) Circulation 97 1998 1440 1445
11. Salonen R., Nyyssonen K., and Porkkala E. A population-based primary preventive trial of the effect of LDL lowering on atherosclerotic progression in carotid and femoral arteries Circulation 92 1995 1758 1764
12. Bellosta S., Ferri N., and Bernini F. Non-lipid-related effects of statins Ann Med 32 2000 164 176
13. Ota K., Suehiro T., and Arii K. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene Metabolism 54 2005 142 150
14. Deakin S., Leviev I., and Guernier S. Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2 Arterioscler Thromb Vasc Biol 23 2003 2083 2089
15. Osaki F., Ikeda Y., and Suehiro T. Roles of Sp1 and protein kinase C in regulation of human serum paraoxonase 1 (PON1) gene transcription in HepG2 cells Atherosclerosis 176 2004 279 287
16. Deakin S., Leviev I., and Brulhart-Meynet M.C. Paraoxonase-1 promoter haplotypes and serum paraoxonase: a predominant role for polymorphic position -107 implicating the Sp1 transcription factor Biochem J 372 2003 643 649
17. Idris I., Gray S., and Donnelly R. Insulin action in skeletal muscle: isozyme-specific effects of protein kinase C Ann N Y Acad Sci 967 2002 176 182
18. Pickett C.A., Manning N., and Akita Y. Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells Mol Endocrinol 16 2002 2840 2852
19. Pal S., Claffey K.P., and Cohen H.T. Activation of Sp1 mediated vascular permeability factor/vascular endothelial growth factor transcription requires specific interaction with protein kinase Cζ J Biol Chem 273 1998 26277 26280
20. Rafty L.A., and Khachigian L.M. Sp1 phosphorylation regulates inducible expression of PDGF B-chain gene via atypical protein kinase Cζ Nucl Acids Res 29 2001 1027 1033
21. Lee S., Park U., and Lee Y.I. Hepatitis C virus core protein transactivates IGF-II gene transcription through acting concurrently on Egr1 and Sp1 sites Virology 283 2001 167 177
22. Suehiro T., Nakamura T., and Inoue M. A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression Atherosclerosis 150 2000 295 298
23. Inoue M., Suehiro T., and Nakanura T. Serum arylesterase/diazoxonase activity and genetic polymorphisms in patients with type 2 diabetes Metabolism 49 2000 1400 1405
24. Harris M.B., Michele A.B., and Sarika G.S. Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors Am J Physiol Heart Circ Physiol 287 2004 H560 H566
25. Kureishi Y., Luo Z., and Shiojima I. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals Nat Med 6 2000 1004 1010
26. Tanaka K., Honda M., and Takabatake T. Anti-apoptotic effect of atorvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, on cardiac myocytes through protein kinase C activation Clin Exp Pharmacol Physiol 31 2004 360 364
27. Chen J.C., Huang K.C., and Lin W.W. HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways Cell Signal 18 2006 32 39
28. Ceolotto G., Papparella I., and Lenzini L. Insulin generates free radicals in human fibroblasts ex vivo by a protein kinase C-dependent mechanism, which is inhibited by pravastatin Free Radic Biol Med 41 2006 473 483
29. Maeda K., Yasunari K., and Sato E.F. Enhanced oxidative stress in neutrophils from hyperlipidemic guinea pig Atherosclerosis 181 2005 87 92
30. Yasunari K., Maeda K., and Minami M. HMG-CoA reductase inhibitors prevent migration of human coronary smooth muscle cells through suppression of increase in oxidative stress Arterioscler Thromb Vasc Biol 21 2001 937 942
31. Zhang Y., Liao M., and Dufau M.L. Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated depression of transcription of the luteinizing hormone receptor gene Mol Cell Biol 26 2006 6748 6761
32. Pal S., Datta K., and Khosravi-Far R. Role of protein kinase Czeta in Ras-mediated transcriptional activation of vascular permeability factor/vascular endothelial growth factor expression J Biol Chem 276 2001 2395 2403
33. Arii K., Suehiro T., and Ota K. Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells Atherosclerosis 202 2009 439 445
34. Gouédard C., Koum-Besson N., and Barouki R. Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins Mol Pharmacol 63 2003 945 956