메뉴 건너뛰기




Volumn 63, Issue 4, 2003, Pages 945-956

Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins

Author keywords

[No Author keywords available]

Indexed keywords

22 HYDROXYCHOLESTEROL; ARYLDIALKYLPHOSPHATASE; ARYLDIALKYLPHOSPHATASE 1; FENOFIBRATE; FLUINDOSTATIN; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; MESSENGER RNA; MEVALONIC ACID; ORGANOPHOSPHATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHOSPHOTRIESTERASE; PRAVASTATIN; SIMVASTATIN; STATINE DERIVATIVE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EID: 0344951233     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.4.945     Document Type: Article
Times cited : (129)

References (40)
  • 1
    • 0032522985 scopus 로고    scopus 로고
    • Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
    • Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, and La Du BN (1998) Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Investig 101:1581-1590.
    • (1998) J Clin Investig , vol.101 , pp. 1581-1590
    • Aviram, M.1    Rosenblat, M.2    Bisgaier, C.L.3    Newton, R.S.4    Primo-Parmo, S.L.5    La Du, B.N.6
  • 2
    • 0035155790 scopus 로고    scopus 로고
    • Gemfibrozil increases paraoxonase activity in type 2 diabetic patients. A new hypothesis of the beneficial action of fibrates?
    • Balogh Z, Seres I, Harangi M, Kovacs P, Kakuk G, and Paragh G (2001) Gemfibrozil increases paraoxonase activity in type 2 diabetic patients. A new hypothesis of the beneficial action of fibrates? Diabetes Metab 27:604-610.
    • (2001) Diabetes Metab , vol.27 , pp. 604-610
    • Balogh, Z.1    Seres, I.2    Harangi, M.3    Kovacs, P.4    Kakuk, G.5    Paragh, G.6
  • 3
    • 0036739584 scopus 로고    scopus 로고
    • The effect of peroxisome proliferator-activated receptors alpha (PPARalpha) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity and plasma paraoxonase 1 (PON 1) activity
    • Beltowski J, Wojcicka G, Mydlarczyk M, and Jamroz A (2002) The effect of peroxisome proliferator-activated receptors alpha (PPARalpha) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity and plasma paraoxonase 1 (PON 1) activity. J Physiol Pharmacol 53:463-475.
    • (2002) J Physiol Pharmacol , vol.53 , pp. 463-475
    • Beltowski, J.1    Wojcicka, G.2    Mydlarczyk, M.3    Jamroz, A.4
  • 10
    • 0030293198 scopus 로고    scopus 로고
    • The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin
    • Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, and Furlong CE (1996) The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat Genet 14:334-336.
    • (1996) Nat Genet , vol.14 , pp. 334-336
    • Davies, H.G.1    Richter, R.J.2    Keifer, M.3    Broomfield, C.A.4    Sowalla, J.5    Furlong, C.E.6
  • 11
    • 0345667926 scopus 로고    scopus 로고
    • Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high-affinity, saturable, desorption mechanism
    • Deakin S, Leviev I, Gomaraschi M, Calabresi L, Franceschini G, and James RW (2001) Enzymatically active paraoxonase-1 is located at the external membrane of producing cells and released by a high-affinity, saturable, desorption mechanism. J Biol Chem 28:28.
    • (2001) J Biol Chem , vol.28 , pp. 28
    • Deakin, S.1    Leviev, I.2    Gomaraschi, M.3    Calabresi, L.4    Franceschini, G.5    James, R.W.6
  • 12
    • 0034721761 scopus 로고    scopus 로고
    • Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation
    • Draganov DI, Stetson PL, Watson CE, Billecke SS, and La Du BN (2000) Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation. J Biol Chem 275:33435-33442.
    • (2000) J Biol Chem , vol.275 , pp. 33435-33442
    • Draganov, D.I.1    Stetson, P.L.2    Watson, C.E.3    Billecke, S.S.4    La Du, B.N.5
  • 14
    • 0031831615 scopus 로고    scopus 로고
    • Paraoxonase activity in the serum and hepatic mRNA levels decrease during the acute phase response
    • Feingold KR, Memon RA, Moser AH, and Grunfeld C (1998) Paraoxonase activity in the serum and hepatic mRNA levels decrease during the acute phase response. Atherosclerosis 139:307-315.
    • (1998) Atherosclerosis , vol.139 , pp. 307-315
    • Feingold, K.R.1    Memon, R.A.2    Moser, A.H.3    Grunfeld, C.4
  • 15
    • 0030885520 scopus 로고    scopus 로고
    • The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism
    • Forman BM, Ruan B, Chen J, Schroepfer GJ Jr, and Evans RM (1997) The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. Proc Natl Acad Sci USA 94:10588-10593.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10588-10593
    • Forman, B.M.1    Ruan, B.2    Chen, J.3    Schroepfer G.J., Jr.4    Evans, R.M.5
  • 17
    • 0032778517 scopus 로고    scopus 로고
    • Protein homocysteinylation: Possible mechanism underlying pathological consequences of elevated homocysteine levels
    • Jakubowski H (1999) Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 13:2277-2283.
    • (1999) FASEB J , vol.13 , pp. 2277-2283
    • Jakubowski, H.1
  • 18
    • 0034635449 scopus 로고    scopus 로고
    • Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation
    • Jakubowski H (2000) Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation. J Biol Chem 275:3957-3962.
    • (2000) J Biol Chem , vol.275 , pp. 3957-3962
    • Jakubowski, H.1
  • 19
    • 0033515056 scopus 로고    scopus 로고
    • Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities
    • Josse D, Xie W, Renault F, Rochu D, Schopfer LM, Masson P, and Lockridge O (1999) Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities. Biochemistry 38:2816-2825.
    • (1999) Biochemistry , vol.38 , pp. 2816-2825
    • Josse, D.1    Xie, W.2    Renault, F.3    Rochu, D.4    Schopfer, L.M.5    Masson, P.6    Lockridge, O.7
  • 21
    • 0032171468 scopus 로고    scopus 로고
    • Lack of predictability of classical animal models for hypolipidemic activity: A good time for mice?
    • Krause BR and Princen HM (1998) Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice? Atherosclerosis 140:15-24.
    • (1998) Atherosclerosis , vol.140 , pp. 15-24
    • Krause, B.R.1    Princen, H.M.2
  • 22
    • 0033973018 scopus 로고    scopus 로고
    • Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations
    • Leviev I and James RW (2000) Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations. Arterioscler Thromb Vasc Biol 20:516-521.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 516-521
    • Leviev, I.1    James, R.W.2
  • 23
    • 0028958850 scopus 로고
    • Paraoxonase protects against chlorpyrifos toxicity in mice
    • Li WF, Furlong CE, and Costa LG (1995) Paraoxonase protects against chlorpyrifos toxicity in mice. Toxicol Lett 76:219-226.
    • (1995) Toxicol Lett , vol.76 , pp. 219-226
    • Li, W.F.1    Furlong, C.E.2    Costa, L.G.3
  • 24
    • 0035851188 scopus 로고    scopus 로고
    • Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
    • Lu TT, Repa JJ, and Mangelsdorf DJ (2001) Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J Biol Chem 276:37735-37738.
    • (2001) J Biol Chem , vol.276 , pp. 37735-37738
    • Lu, T.T.1    Repa, J.J.2    Mangelsdorf, D.J.3
  • 25
    • 0034745613 scopus 로고    scopus 로고
    • High-dose simvastin (80 mg/day) decreases plasma concentrations of total homocyst(e)ine in patients with hypercholesteromia
    • Luftjohann D, Sigit JI, Locatelli S, von Bergmann K, and Schmidt HH (2001) High-dose simvastin (80 mg/day) decreases plasma concentrations of total homocyst(e)ine in patients with hypercholesteromia. Atherosclerosis 155:265-266.
    • (2001) Atherosclerosis , vol.155 , pp. 265-266
    • Luftjohann, D.1    Sigit, J.I.2    Locatelli, S.3    Von Bergmann, K.4    Schmidt, H.H.5
  • 29
    • 0032500607 scopus 로고    scopus 로고
    • Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress. Critical contribution of nuclear factor 1
    • Morel Y and Barouki R (1998) Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress. Critical contribution of nuclear factor 1. J Biol Chem 273:26969-26976.
    • (1998) J Biol Chem , vol.273 , pp. 26969-26976
    • Morel, Y.1    Barouki, R.2
  • 30
    • 0035976903 scopus 로고    scopus 로고
    • Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein
    • Ng CJ, Wadleigh DJ, Gangopadhyay A, Hama S, Grijalva VR, Navab M, Fogelman AM, and Reddy ST (2001) Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J Biol Chem 276:44444-44449.
    • (2001) J Biol Chem , vol.276 , pp. 44444-44449
    • Ng, C.J.1    Wadleigh, D.J.2    Gangopadhyay, A.3    Hama, S.4    Grijalva, V.R.5    Navab, M.6    Fogelman, A.M.7    Reddy, S.T.8
  • 31
    • 0029937118 scopus 로고    scopus 로고
    • The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family
    • Primo-Parmo SL, Sorenson RC, Teiber J, and La Du BN (1996) The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family. Genomics 33:498-507.
    • (1996) Genomics , vol.33 , pp. 498-507
    • Primo-Parmo, S.L.1    Sorenson, R.C.2    Teiber, J.3    La Du, B.N.4
  • 32
    • 0035977852 scopus 로고    scopus 로고
    • The potential for toxic effects of chronic, low-dose exposure to organophosphates
    • Ray DE and Richards PG (2001) The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol Lett 120:343-351.
    • (2001) Toxicol Lett , vol.120 , pp. 343-351
    • Ray, D.E.1    Richards, P.G.2
  • 37
    • 0033817620 scopus 로고    scopus 로고
    • Effect of simvastatin therapy on paraoxonase activity and related lipoproteins in familial hypercholesterolemic patients
    • Tomas M, Senti M, Garcia-Faria F, Vila J, Torrents A, Covas M, and Marrugat J (2000) Effect of simvastatin therapy on paraoxonase activity and related lipoproteins in familial hypercholesterolemic patients. Arterioscler Thromb Vasc Biol 20:2113-2119.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2113-2119
    • Tomas, M.1    Senti, M.2    Garcia-Faria, F.3    Vila, J.4    Torrents, A.5    Covas, M.6    Marrugat, J.7
  • 38
    • 0035910528 scopus 로고    scopus 로고
    • Oxidized phospholipids induce changes in hepatic paraoxonase and ApoJ but not monocyte chemoattractant protein-1 via interleukin-6
    • Van Lenten BJ, Wagner AC, Navab M, and Fogelman AM (2001) Oxidized phospholipids induce changes in hepatic paraoxonase and ApoJ but not monocyte chemoattractant protein-1 via interleukin-6. J Biol Chem 276:1923-1929.
    • (2001) J Biol Chem , vol.276 , pp. 1923-1929
    • Van Lenten, B.J.1    Wagner, A.C.2    Navab, M.3    Fogelman, A.M.4
  • 39
    • 0032475854 scopus 로고    scopus 로고
    • The nuclear receptors peroxisome proliferator-activated receptor a and Rev-erba mediate the species-specific regulation of apolipoprotein A-I expression by fibrates
    • Vu-Dac N, Chopin-Delannoy S, Gervois P, Bonnelye E, Martin G, Fruchart JC, Laudet V, and Staels B (1998) The nuclear receptors peroxisome proliferator-activated receptor a and Rev-erba mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J Biol Chem 273:25713-25720.
    • (1998) J Biol Chem , vol.273 , pp. 25713-25720
    • Vu-Dac, N.1    Chopin-Delannoy, S.2    Gervois, P.3    Bonnelye, E.4    Martin, G.5    Fruchart, J.C.6    Laudet, V.7    Staels, B.8
  • 40
    • 0035822253 scopus 로고    scopus 로고
    • Effects of fenofibrate and gemfibrozil on plasma homocysteine
    • Westphal S, Dierkes J, and Luley C (2001) Effects of fenofibrate and gemfibrozil on plasma homocysteine. Lancet 358:39-40.
    • (2001) Lancet , vol.358 , pp. 39-40
    • Westphal, S.1    Dierkes, J.2    Luley, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.