The effect of Na2CO3, NaF and NH4OH on the stability and release behavior of sol-gel derived silica xerogels embedded with bioactive compounds

Acta Biomaterialia

Volumn 6, Issue 6, 2010, Pages 2246-2253

  Morpurgo, M ^a   Teoli, D ^a   Pignatto, M ^a   Attrezzi, M ^a   Spadaro, F ^a   Realdon, N ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Controlled release; Inorganic polymer; Polymer stability; Polymer structure; Sol gel silica

Indexed keywords

AMMONIA; CARBONATION; CATALYSTS; CONTROLLED DRUG DELIVERY; DIGITAL STORAGE; INORGANIC POLYMERS; POLYMERIZATION; SILICA; SODIUM BICARBONATE; SODIUM CARBONATE; SOL-GEL PROCESS; SOL-GELS; STABILITY; TARGETED DRUG DELIVERY; XEROGELS;

CONTROLLED RELEASE; INORGANICS; POLYMER STABILITY; POLYMER STRUCTURE; RELEASE BEHAVIORS; SILICA XEROGEL; SOL-GEL SILICA; STABILITY BEHAVIOR; SYNAERESIS; ]+ CATALYST;

TEMPERATURE;

AMMONIA; CARBONIC ACID; FLUORIDE SODIUM; SILICA GEL; SODIUM CARBONATE; UNCLASSIFIED DRUG; XEROGEL; CARBONIC ACID DERIVATIVE; DRUG; DRUG CARRIER; SILICON DIOXIDE; SODIUM HYDROXIDE;

ARTICLE; CATALYST; DRUG RELEASE; DRUG STABILITY; LOW TEMPERATURE; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; SYNTHESIS; ABSORPTION; CHEMISTRY; DIFFUSION; DRUG FORMULATION; GEL; MATERIALS TESTING; METHODOLOGY; PHASE TRANSITION;

ABSORPTION; CARBONATES; DIFFUSION; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; GELS; MATERIALS TESTING; PHARMACEUTICAL PREPARATIONS; PHASE TRANSITION; SILICON DIOXIDE; SODIUM FLUORIDE; SODIUM HYDROXIDE;

EID: 77956624398     PISSN: 17427061     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actbio.2009.12.021     Document Type: Article

References (34)

1. Brinker CJ, Scherer GW. Sol-gel science. The physics and chemistry of sol-gel processing. San Diego, CA: Academic Press; 1989. p. 1-11.
2. Unger K, Rupprecht H, Valentin B, Kircher W. The use of porous and surface modified silicas as drug delivery and stabilizing agents. Drug Dev Ind Pharm 1983;9(1-2): 69-91.
3. Bottcher H, Slowik P, Sub W. Sol-gel carrier system for controlled drug delivery. J Sol-Gel Sci Technol 1998;13:277-81.
4. Kortesuo P, Ahola M, Kangas M, Jokinen M, Leino T, Vuorilehto L, et al. Effect of synthesis parameters of the sol-gel-processed spray-dried silica gel microparticles on the release rate of dexmedetomidine. Biomaterials 2002;23(13):2795-801.
5. Kortesuo P, Ahola M, Karlsson S, Kangasniemi I, Kiesvaara J, Yli-Urpo A. Sol-gel-processed sintered silica xerogel as a carrier in controlled drug delivery. J Biomed Mater Res 1999;44(2):162-7.
6. Barbè C, Bartlett J, Kong L, Finnie K, Lin H, Larkin M, et al. Silica particles: a novel drug delivery system. Adv Mater 2004;16(21):1959-66.
7. Barbè C, Kong L, Finnie KS, Calleja S, Hanna JV, Drabarek E, et al. Sol-gel matrices for controlled release: from macro to nano using emulsion polymerisation. J Sol-Gel Sci Technol 2008;46(3):393-409.
8. Roveri N, Morpurgo M, Palazzo B, Parma B, Vivi L. Silica xerogels as a delivery system for the controlled release of different molecular weight heparins. Anal Bioanal Chem 2005;381(3):601-6.
9. Avnir D, Coradin T, Lev O, Livage J. Recent bio-applications of sol-gel materials. J Mater Chem 2006;16(11):1013-30.
10. Teoli D, Parisi L, Realdon N, Guglielmi M, Rosato A, Morpurgo M. Wet sol-gel derived silica for controlled release of proteins. J Control Release 2006;116(3):295-303.
11. Yilmaz E, Bengisu M. Drug entrapment in silica microspheres through a single step sol-gel process and in vitro release behavior. J Biomed Mater Res B Appl Biomater 2006;77(1):149-55.
12. Czarnobaj K, Lukasiak J. In vitro release of cisplatin from sol-gel processed organically modified silica xerogels. J Mater Sci Mater Med 2007;18(10):2041-4.
13. Giri S, Trewyn BG, Lin VSY. Mesoporous silica nanomaterial-based biotechnological and biomedical delivery systems. Nanomedicine 2007;2(1):99-111.
14. Margiotta N, Ostuni R, Teoli D, Morpurgo M, Realdon N, Palazzo B, et al. Bisphosphonate complexation and calcium doping in silica xerogels as a combined strategy for local and controlled release of active platinum antitumor compounds. Dalton Trans 2007 (29):3131-9.
15. Maver U, Godec A, Bele M, Planinsek O, Gaberscek M, Srcic S, et al. Novel hybrid silica xerogels for stabilization and controlled release of drug. Int J Pharm 2007;330(1-2): 164-74.
16. Czarnobaj K. Preparation and characterization of silica xerogels as carriers for drugs. Drug Deliv 2008;15(8):485-92.
17. Rigby SP, Fairhead M, van der Walle CF. Engineering silica particles as oral drug delivery vehicles. Curr Pharm Des 2008;14(18):1821-31.
18. Morpurgo M, Teoli D, Palazzo B, Bergamin E, Realdon N, Guglielmi M. Influence of synthesis and processing conditions on the release behavior and stability of sol-gel derived silica xerogels embedded with bioactive compounds. Farmaco 2005;60(8):675-83.
19. 29Si NMR. J Non-Cryst Solids 1989;111(2-3): 153-66.
20. Koroleff F. In: Kremling K, Grasshoff K, Ehrhardt M, editors. Methods of seawater analysis. Weinheim: Wiley-VCH; 1983. p. 174-83.
21. Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci 1963;52:1145-9.
22. EMEA. Note for guidance on the investigation of bioavailability and bioequivalence. CPMP/EWP/QWP/1401/98; 2001.
23. Estella J, Echeverria JC, Laguna M, Garrido JJ. Effects of aging and drying conditions on the structural and textural properties of silica gels. Microporous Mesoporous Mater 2007;102(1-3): 274-82.
24. Finnie KS, Waller DJ, Perret FL, Krause-Heuer AM, Lin HQ, Hanna JV, et al. Biodegradability of sol-gel silica microparticles for drug delivery. J Sol-Gel Sci Technol 2009;49(1):12-8.
25. 2 matrices for release of large biologically active molecules. J Sol-Gel Sci Technol 2005;36(2):147-56.
26. 2. Int J Pharm 2007;336(2):382-90.
27. Lenza RFS, Vasconcelos WL. Synthesis and properties of microporous sol-gel silica membranes. J Non-Cryst Solids 2000;273:164-9.
28. He L, Powers K, Baney RH, Gower L, Duran RS, Sheth P, et al. Mesoporous TMOS-MTMS copolymer silica gels catalyzed by fluoride. J Non-Cryst Solids 2001;289:97-105.
29. 4OH. Langmuir 1997;13:6310-4.
30. Intakes. TSCotSEoDR. Dietary Reference Intakes: Applications in Dietary Assessment by a Report of the Subcommittees on Interpretation and Uses of Dietary Reference Intakes and Upper Reference Levels of Nutrients. Washington, DC: National Academy Press; 2001. p. 247.
31. Kim SM, Chakrabarti EO, Whang CM. Effects of pH during the base catalyzed reaction of two steps acid/base catalyzed process on the microstructure and physical properties of poly (dimethoxysiloxane) modified silica xerogels. J Sol-Gel Sci Technol 2002;27:149-55.
32. Musgo J, Echeverria JC, Estella J, Laguna M, Garrido JJ. Ammonia-catalyzed silica xerogels: simultaneous effects of pH, synthesis temperature, and ethanol:TEOS and water:TEOS molar ratios on textural and structural properties. Microporous Mesoporous Mater 2009;118(1-3): 280-7.
33. Silva CR, Airoldi C. Acid and base catalysts in the hybrid silica sol-gel process. J Colloid Interface Sci 1997;195(2):381-7.
34. Kortesuo P, Ahola M, Kangas M, Leino T, Laakso S, Vuorilehto L, et al. Alkylsubstituted silica gel as a carrier in the controlled release of dexmedetomidine. J Control Release 2001;76(3):227-38.