Immune monitoring with iTAg MHCTetramers for prediction of recurrent or persistent cytomegalovirus infection or disease in allogeneic hematopoietic stem cell transplant recipients: A prospective multicenter study

Blood

Volumn 116, Issue 10, 2010, Pages 1655-1662

  Gratama, Jan W ^a   Boeckh, Michael ^b   Nakamura, Ryotaro ^c   Cornelissen, Jan J ^a   Brooimans, Rik A ^a   Zaia, John A ^c   Forman, Stephen J ^c   Gaal, Karl ^c   Bray, Kurtis R ^d   Gasior, Gail H ^d   Boyce, Christopher S ^d   Sullivan, Linda A ^d   Southwick, Paula C ^d  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Fred Hutchinson Cancer Research Center   (United States)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d BECKMAN COULTER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA A1 ANTIGEN; HLA B ANTIGEN; HLA B7 ANTIGEN; HLA-A*01:01 ANTIGEN; HLA-B*07:02 ANTIGEN;

ADOLESCENT; ADULT; AGED; ALLOTRANSPLANTATION; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; CYTOLOGY; CYTOMEGALOVIRUS INFECTIONS; FEMALE; FLOW CYTOMETRY; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TEST; HUMAN; IMMUNOLOGICAL MONITORING; IMMUNOLOGY; LONGITUDINAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; POSTOPERATIVE COMPLICATIONS; PROCEDURES; PROGNOSIS; PROSPECTIVE STUDY; REPRODUCIBILITY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; CD4-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS INFECTIONS; FEMALE; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HLA-A ANTIGENS; HLA-A1 ANTIGEN; HLA-B ANTIGENS; HLA-B7 ANTIGEN; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MONITORING, IMMUNOLOGIC; POSTOPERATIVE COMPLICATIONS; PROGNOSIS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 77956608710     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-03-273508     Document Type: Article

References (13)

1. Boeckh M, Nichols WG. The impact of cytomegalovirus serostatus of donor and recipient before hematopoietic stem cell transplantation in the era of antiviral prophylaxis and preemptive therapy. Blood. 2004;103(6):2003-2008. (Pubitemid 38326213)
2. Altman JD, Moss PAH, Goulder PJR, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996;274(5284):94-96.
3. Mori M, Beatty PG, Graves M, Boucher KM, Milford EL. HLA gene and haplotype frequencies in the North American population: the National Marrow Donor Program Donor Registry. Transplantation. 1997;64(7):1017-1027. (Pubitemid 27446768)
4. Marsh S, Parham P, Barber L. The HLA Fact Book. San Diego, CA: Academic Press; 2000.
5. Longmate J, York J, La Rosa C, et al. Population coverage by HLA class-1 restricted cytotoxic T-lymphocyte epitopes. Immunogenetics. 2001;52(3-4):165- 173.
6. Brooimans RA, Boyce CS, Popma J, et al. Analytical performance of a standardized singleplatform MHC tetramer assay for the identification and enumeration of CMV-specific CD8+ T lymphocytes. Cytometry A. 2008;73(11):992-1000.
7. Gratama JW, van Esser JW, Lamers CH, et al. Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection. Blood. 2001;98(5):1358-1364.
8. Cwynarski K, Ainsworth J, Cobbold M, et al. Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation. Blood. 2001;97(5):1232-1240. (Pubitemid 32183744)
9. Aubert G, Hassan-Walker AF, Madrigal JA, et al. Cytomegalovirus-specific cellular immune responses and viremia in recipients of allogeneic stem cell transplants. J Infect Dis. 2001;184(8):955-963. (Pubitemid 32955111)
10. Ozdemir E, St John LS, Gillespie G, et al. Cytomegalovirus reactivation following allogeneic stem cell transplantation is associated with the presence of dysfunctional antigen-specific CD8+ T cells. Blood. 2002;100(10):3690-3697. (Pubitemid 35303940)
11. Morita-Hoshi Y, Heike Y, Kawakami M, et al. Functional analysis of cytomegalovirus-specific T lymphocytes compared to tetramer assay in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant. 2008;41(6):515-521. (Pubitemid 351472142)
12. Gamadia LE, Remmerswaal EB, Weel JF, Bemelman F, van Lier RA, ten Berge IJ. Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood. 2003;101(7):2686-2692.
13. Gratama JW, Brooimans RA, van der Holt B, et al. Monitoring cytomegalovirus IE-1 and pp65-specific CD4+ and CD8+ T-cell responses after allogeneic stem cell transplantation may identify patients at risk for recurrent CMV reactivations. Cytometry B Clin Cytom. 2008;74(4):211-220.