High mean platelet volume, low-grade systemic coagulation, and fibrinolytic activation are associated with pre-term delivery and low APGAR score in intrahepatic cholestasis of pregnancy

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 23, Issue 10, 2010, Pages 1205-1210

  Kebapcilar, Ayse G ^a   Taner, Cuneyt E ^a   Kebapcilar, Levent ^b   Bozkaya, Giray ^b  

^a Izmir Aegean Obstetrics and Gynecology Teaching Hospital   (Turkey)

^b UNIVERSITY OF HEALTH SCIENCES   (Turkey)

Author keywords

D dimer; Intrahepatic cholestasis of pregnancy; low APGAR score; mean platelet volume; systolic diastolic ratio; umbilical artery

Indexed keywords

BILE ACID; D DIMER;

ADULT; APGAR SCORE; ARTICLE; BLOOD CLOTTING; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; FETUS OUTCOME; FIBRINOLYSIS; HEMATOLOGICAL PARAMETERS; HUMAN; HUMAN CELL; INTRAHEPATIC CHOLESTASIS; NEWBORN; PREGNANCY COMPLICATION; PREGNANCY DISORDER; PREGNANT WOMAN; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; THIRD TRIMESTER PREGNANCY; THROMBOCYTE VOLUME; UMBILICAL ARTERY;

ADULT; APGAR SCORE; BILE ACIDS AND SALTS; BLOOD PLATELET DISORDERS; CASE-CONTROL STUDIES; CHOLESTASIS, INTRAHEPATIC; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; INFANT, NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PROSPECTIVE STUDIES; PULSATILE FLOW; ULTRASONOGRAPHY, PRENATAL; UMBILICAL ARTERIES; YOUNG ADULT;

EID: 77956607556     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767051003653278     Document Type: Article

References (29)

1. Hay JE. Liver disease in pregnancy. Hepatology. 2008;47: 1067-1076.
2. Guntupalli SR, Steingrub J. Hepatic disease and pregnancy: an overview of diagnosis and management. Crit Care Med 2005;33(10 Suppl):S332-S339.
3. Davidson KM. Intrahepatic cholestasis of pregnancy. Semin Perinatol 1998;22:104-111.
4. Herre HD, Engelmann C, Wiken HP. Diagnosis and therapy of blood coagulation disorders in intrahepatic cholestasis. Zentralbl Gynakol 1976;98:217-219.
5. Binder T, Salaj P, Dyr EJ, Vańfková M, Hrachovinová I. Hematological aspects of gestational cholestatic hepatosis (ICP). Ceska Gynekol 2006;71:99-102.
6. Brenner B. Haemostatic changes in pregnancy. Thromb Res 2004;114:409-414.
7. Wada H, Sakuragawa N, Mori Y, Takagi M, Nakasaki T, Shimura M, Hiyoyama K, Nisikawa M, Gabazza EC, Deguchi K, Kazama M, Shiku H. Hemostatic molecular markers before the onset of disseminated intravascular coagulation. Am J Hematol 1999;60:273-278.
8. Bick RL. Syndromes of disseminated intravascular coagulation in obstetrics, pregnancy, and gynecology. Objective criteria for diagnosis and management. Hematol Oncol Clin North Am 2000;14:999-1044.
9. Gagnon R, Van den Hof M. Diagnostic Imaging Committee, Executive and Council of the Society of Obstetricians and Gynaecologists of Canada. The use of fetal Doppler in obstetrics. J Obstet Gynaecol Can 2003;25:601-614.
10. Alsulyman OM, Ouzounian JG, Ames-Castro M, et al. Intrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management. Am J Obstet Gynecol 1996;175:957-960.
11. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983;32:443-460.
12. Gillum RF, Mussolino ME, Madans JH. Counts of neutrophils, lymphocytes, and monocytes cause specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol 2005;15:266-271.
13. Turley SD, Dietschy JM. Reevaluation of the 3-hydroxysteroid dehydrogenase assay for total bile acids in bile. J Lipid Res 1978;19:924-928.
14. Acharya G, Wilsgaard T, Berntsen GK, Maltau JM, Kiserud T. Reference ranges for serial measurements of umbilical artery Doppler indices in the second half of pregnancy. Am J Obstet Gynecol 2005;192:937-944. (Pubitemid 40311293)
15. Wells PS, Anderson DR, Rodger M, et al. Evaluation of Ddimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med 2003;349:1227-1235.
16. Schrecengost JE, LeGallo RD, Boyd JC, Moons KG, Gonias SL, Rose CE Jr, Bruns DE. Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism. Clin Chem 2003;49:1483-1490.
17. Kaczyń ska A, Szulc M, Styczyń ski G, Kostrubiec M, Pacho R, Pruszczyk P. Right ventricle injury during acute pulmonary embolism leads to its remodeling. Int J Cardiol 2008;125: 120-121.
18. Farber HW, Loscalzo J: Prothrombotic mechanisms in primary pulmonary hypertension. J Lab Clin Med 1999;134: 561-566.
19. Chaouate A, Weitzenblum E, Higenbottam T: The role of thrombosis in severe pulmonary hypertension. Eur Respir J 1996;9:356-363.
20. Sepú lveda WH, Gonzalez C, Cruz MA, Rudolph MI. Vasoconstrictive effect of bile acids on isolated human placental chorionic veins. Eur J Obstet Gynecol Reprod Biol 1991;42:211-215.
21. Lammert F, Marschall HU, Glantz A, Matern S. Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management. J Hepatol 2002;33:1012-1021.
22. Rodrigues CMP, Marin JJG, Brites D. Bile acid patterns in meconium are influenced by cholestasis of pregnancy and are not altered by ursodeoxycholic acid treatment. Gut 1999;45: 446-452.
23. Wagenvoort CA, Mulder GH. Thrombotic lesions in primary plexogenic arteriopathy. Chest 1993;103:844-849.
24. Glantz A, Marschall HU, Mattsson LA. Intrahepatic cholestasis of pregnancy: relationships between bile acid levels and fetal complication rates. Hepatology. 2004;40: 467-474.
25. Egerman RS, Riely CA. Predicting fetal outcome in intrahepatic cholestasis of pregnancy: is the bile acid level sufficient? Hepatology 2004;40:287-288.
26. Fagan EA. Intrahepatic cholestasis of pregnancy. Clin Liver Dis 1999;3:603-632.
27. Taylor FB Jr, Toh CH, HootsWK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001;86:1327-1330.
28. Martin JF, Trowbridge EA, Salmon G, Plumb J. The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration. Thromb Res 1983;32:443-460.
29. Ross R. Atherosclerosis: an inflammatory diesase. N Engl J Med 1999;340:115-126.