Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment

Gut

Volumn 45, Issue 3, 1999, Pages 446-452

  Rodrigues, C M P ^a   Marin J J G ^c   Brites, D ^b  

^a INSTITUTO SUPERIOR DE CIÊNCIAS DA SAÚDE EGAS MONIZ   (Portugal)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c NONE

Author keywords

Bile acids; Cholestasis; Cholic acid; Meconium; Pregnancy; Ursodeoxycholic acid therapy

Indexed keywords

CHOLIC ACID; URSODEOXYCHOLIC ACID;

ADULT; AMNION FLUID; ARTICLE; BILE SECRETION; CHOLESTASIS; DRUG EFFECT; ENTEROHEPATIC CIRCULATION; FEMALE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER FUNCTION; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MATERNAL SERUM; MECONIUM; PREGNANCY; PRIORITY JOURNAL;

EID: 0032775761     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.45.3.446     Document Type: Article

References (52)

1. 1 Reyes H. The enigma of intrahepatic cholestasis of pregnancy: lessons from Chile. Hepatology 1982;2:87-96.
2. 2 Van Dyke RW. The liver in pregnancy. In: Zakim D, Boyer TD, eds. Hepatology: a textbook of liver disease. Philadelphia: WB Saunders, 1990;2:1438-59.
3. 3 Reyes H, Gonzalez MC, Ribalta J, et al. Prevalence of intrahepatic cholestasis of pregnancy in Chile. Ann Intern Med 1978;88:487-93.
4. 4 Brites D, Rodrigues CMP, van-Zeller H, et al. Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in a high incidence area: Portugal. Eur J Obster Gynecol Reprod Biol 1998;80:31-8.
5. 5 Fisk NM, Storey GNB. Fetal outcome in obstetric cholestasis. Br J Obstet Gynaecol 1988;95:1137-43.
6. 6 Reyes H, Radrigán ME, Gonzalez MC, et al. Steatorrhea in patients with intrahepatic cholestasis of pregnancy. Gastroenterology 1987;93:584-90.
7. 7 Alsulyman OM, Ouzounian JG, Ames-Castro M, et al. Intrahepatic cholestasis of pregnancy: perinatal outcome associated with expectant management. Am J Obstet Gynecol 1996;175:957-60.
8. 8 Laatikainen T. Fetal bile acid levels in pregnancies complicated by maternal intrahepatic cholestasis. Am J Obstet Gynecol 1975;122:852-6.
9. 9 Heikkinen J, Mäentausta O, Tuimala R, et al. Amniotic fluid bile acids in normal and pathologic pregnancy. Obstet Gynecol 1980;56:60-4.
10. 10 Shaw D, Frohlich J, Wittmann BAK, et al. A prospective study of 18 patients with cholestasis of pregnancy. Am J Obstet Gynecol 1982;142:621-5.
11. 11 Heikkinen J, Ylöstalo P, Mäentausta O, et al. Bile acids in maternal serum, umbilical cord serum and amniotic fluid of healthy women, women with pruritus and patients with intrahepatic cholestasis of pregnancy. J Obstet Gynaecol 1983;4:17-20.
12. 12 Serrano MA, Brites D, Larena MG, et al. Beneficial effect of ursodeoxycholic acid on alterations induced by cholestasis of pregnancy in bile acid transport across the human placenta. J Hepatol 1998;28:829-39.
13. 13 Mazzella G, Rizzo N, Salzetta A, et al. Management of intrahepatic cholestasis in pregnancy. Lancet 1991;338:1594-5.
14. 14 Palma J, Reyes H, Ribalta J, et al. Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy. Hepatology 1992;15:1043-7.
15. 15 Floreani A, Paternoster D, Grella V, et al. Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy. Br J Obstet Gynaecol 1994;101:64-5.
16. 16 Davies MH, da Silva RCMA, Jones SR, et al. Fetal mortality associated with cholestasis of pregnancy and the potential benefit of therapy with ursodeoxycholic acid. Gut 1995;37: 580-4.
17. 17 Meng, L-J, Reyes H, Axelson M, et al. Progesterone metabolites and bile acids in serum of patients with intrahepatic cholestasis of pregnancy: effect of ursodeoxycholic acid therapy. Hepatology 1997;26:1573-9.
18. 18 Meng, L-J, Reyes H, Palma J, et al. Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy. J Hepatol 1997;27: 1029-40.
19. 19 Palma J, Reyes H, Ribalta J, et al. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo. J Hepatol 1997;27:1022-8.
20. 20 Brites D, Rodrigues CMP, Oliveira N, et al. Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy. J Hepatol 1998;28: 91-8.
21. 21 Brites D, Rodrigues CMP, Cardoso MC, et al. Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration. Eur J Obstet Gynecol Reprod Biol 1998;76:165-8.
22. 22 Brites D, Oliveira N, van-Zeller H, et al. Correction of fetal cord serum bile acid profile by maternal ursodeoxycholic acid therapy in cholestasis of pregnancy [abstract]. J Hepatol 1997;26:163A.
23. 23 Brites D, El-Mir MY, Oliveira N, et al. Amniotic fluid bile acid changes in the course of ursodeoxycholic acid therapy in intrahepatic cholestasis of pregnancy [abstract]. J Hepatol 1997;26:164A.
24. 24 Back P, Walter K. Developmental pattern of bile acid metabolism as revealed by bile acid analysis of meconium. Gastroenterology 1980;78:671-6.
25. 25 Lester R, Pyrek Jst, Little JM, et al. Nature of bile acids in the fetus and newborn infant. J Pediatr Gastroenterol Nutr 1983;2:S197-206.
26. 26 Colombo C, Zuliani G, Ronchi M, et al. Biliary bile acid composition of the human fetus in the early gestation. Pediatr Res 1987;21:197-200.
27. 27 Setchell KD, Dumaswala R, Colombo C, et al. Hepatic bile acid metabolism during early development revealed from the analysis of human fetal gallbladder bile. J Biol Chem 1988;263:16637-44.
28. 28 Kimura A, Yamakawa R, Ushijima K, et al. Fetal bile acid metabolism during infancy: analysis of 1β-hydroxylated bile acids in urine, meconium and feces. Hepatology 1994;20:819-24.
29. 29 Labbe D, Gerhard M-F, Myara A, et al. High-performance liquid Chromatographic determination of tauro-and glyco-conjugated bile acids in human serum. J Chromatogr 1989; 490:275-84.
30. 30 Feldmann D, Fenech C, Cuer JF. Evaluation of a sample preparation procedure for bile acids in serum and bile. Clin Chem 1983;29:1694.
31. 31 Mashige F, Imai K, Osuga T. A simple and sensitive assay of bile acids. Clin Chim Acta 1976;70:79-86.
32. 32 Brites D, Silva R. Doseamento enzimático dos ȧcidos biliares. Optimização da reacção e valores normais. Revista Purtuguesa de Farmácia 1985;36:8-14.
33. 33 Beke R, De Weerdt GA, Parijs J, Huybrechts et al. Separation of conjugated and unconjugated bile acids by thin layer chromatography. Clin Chim Acta 1976;70:197-9.
34. 34 Goswami SK, Frey CF. Thin-layer Chromatographic method for the separation of conjugated deoxycholic acid from conjugated chenodeoxycholic acid. J Chromatogr 1978;145:147-50.
35. 35 Correia LE, Brites D. Separação, identificação e quantificação dos diferentes ácidos biliares no soro. Revista Portuguesa de Farmácia 1985;36:30-5.
36. 36 Setchell KDR, Lawson AM, Tanida N, et al. General methods for the analysis of metabolic profiles of bile acids and related compounds in feces. J Lipid Res 1983;24:1085-100.
37. 37 Hirano Y, Miyazaki H, Higashidate S, et al. Analysis of 3-sulfated and nonsulfated bile acids by one-step hydrolysis and high performance liquid chromatography. J Lipid Res 1987;28:1524-9.
38. 38 Nair PP, Garcia CC. A modified gas-liquid Chromatographic procedure for the rapid determination of bile acids in biological fluids. Anal Biochem 1969;29:164-6.
39. 39 Almé B, Bremmelgaard A, Sjövall J, et al. Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatography-mass spectrometry. J Lipid Res 1977;18:339-62.
40. 40 Fales HM, Jaouni JM, Babashak JF. Simple device for preparing ethereal diazomethane without resorting to co-distillation. Anal Chem 1973;45:2302-3.
41. 41 Blau K, King GS. Handbook of derivatives for Chromatography. London: Heyden & Son, 1978.
42. 42 Axelson M, Sjövall J. Separation and computerized gas chromatography-mass spectrometry of unconjugated neutral steroids in plasma. J Steroid Biochem 1974;5:733-8.
43. 43 Lawson AM, Setchell KDR. Mass spectrometry in bile acids. In: Setchell KDR, Kritchevsky D, Nair P, eds. The bile acids. New York: Plenum Press, 1988;4:167-267.
44. 44 Setchell KDR. Liquid-solid extraction lipophilic gel chromatography and capillary column gas chromatography in the analysis of bile acids from biological samples. In: Barbara I, Dowling RH, Hofmann AF, et al, eds. Bile acids in gastroenterology. Lancaster: MTP Press, 1982;1-18.
45. 45 Sewell RB, Hardy KJ, Smallwood RA, et al. Fetal bile salt metabolism: placental transfer of dihydroxy bile salts in sheep. Am J Physiol 1982;243:G172-5.
46. 46 Brites D, Rodrigues CMP. Elevated levels of bile acids in colostrum in patients with cholestasis of pregnancy are decreased following ursodeoxycholic acid therapy. J Hepatol 1998;29:743-51.
47. 47 Kurosawa T, Mahara R, Nittono H, et al. Synthesis of 6-hydroxylated bile acids and identification of 3α,6α,7α,12α-tetrahydroxy-5β-cholan-24-oic acid in human meconium and neonatal urine. Chem Pharm Bull (Tokyo) 1989;37:557-9.
48. 1 bile acids in neonatal bile acid metabolism. Arch Dis Child Fetal Neonatal Ed 1997;77:F52-6.
49. 40 Murai T, Mahara R, Kurosawa T, et al. Determination of fetal bile acids in biological fluids from neonates by gas chromatography-negative ion chemical ionization mass spectrometry. J Chromatogr B Biomed Appl 1997;28:13-22.
50. 50 Jönsson G, Midtvedt A-C, Norman A, et al. Intestinal microbial bile acid transformation in healthy infants. J Pediatr Gastroenterol Nutr 1995;20:394-402.
51. 51 Sharp HL, Peller J, Carey JB. Primary and secondary bile acids in meconium. Pediatr Res 1971;5:274-9.
52. 52 Laatikainen TJ, Lehtonen PJ, Hesso AE. Fetal sulfated and nonsulfated bile acids in intrahepatic cholestasis of pregnancy. J Lab Clin Med 1978;92:185-93.