Magnesium sulfate normalizes placental interleukin-6 secretion in preeclampsia

Journal of Interferon and Cytokine Research

Volumn 30, Issue 9, 2010, Pages 683-690

  Amash, Alaa ^a   Holcberg, Gershon ^a,b   Sheiner, Eyal ^a,b   Huleihel, Mahmoud ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 6; MAGNESIUM SULFATE;

ADULT; ARTICLE; BLOOD PRESSURE; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; HYPERTENSION; PLACENTA; PREECLAMPSIA; PREGNANCY; PREGNANT WOMAN; PRIORITY JOURNAL; TISSUE PERFUSION; VAGINAL DELIVERY;

ADULT; ANTI-INFLAMMATORY AGENTS; FEMALE; HUMANS; INFANT, NEWBORN; INFLAMMATION MEDIATORS; INTERLEUKIN-6; ISRAEL; MAGNESIUM SULFATE; PLACENTA; PLACENTAL CIRCULATION; PRE-ECLAMPSIA; PREGNANCY; UP-REGULATION;

EID: 77956606358     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2010.0011     Document Type: Article

References (42)

1. Akira S, Hirano T, Taga T, Kishimoto T. 1990. Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J 4:2860-2867.
2. Amash A, Weintraub AY, Sheiner E, Zeadna A, Huleihel M, Holcberg G. 2010. Possible therapeutic effect of magnesium sulfate in preeclampsia by downregulation of placental tumor necrosis factor-alpha secretion. Eur Cytokine Netw 21:1-7.
3. Austgulen R, Lien E, Liabakk NB, Jacobsen G, Arntzen KJ. 1994. Increased levels of cytokines and cytokine activity modifiers in normal pregnancy. Eur J Obstet Gynecol Reprod Biol 57:149-155.
4. Belfort MA, Moise KJ Jr. 1992. Effect of magnesium sulfate on maternal brain blood flow in preeclampsia: a randomized, placebo-controlled study. Am J Obstet Gynecol 167:661-666.
5. Benyo DF, Smarason A, Redman CW, Sims C, Conrad KP. 2001. Expression of inflammatory cytokines in placentas from women with preeclampsia. J Clin Endocrinol Metab 86: 2505-2512.
6. Bowen JM, Chamley L, Mitchell MD, Keelan JA. 2002. Cytokines of the placenta and extra-placental membranes: biosynthesis, secretion and roles in establishment of pregnancy in women. Placenta 23:239-256.
7. Conrad KP, Miles TM, Benyo DF. 1998. Circulating levels of immunoreactive cytokines in women with preeclampsia. Am J Reprod Immunol 40:102-111.
8. Dammann O, Leviton A. 1997. Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr Res 42:1-8.
9. 2\+. J Clin Invest 89:1988-1994.
10. Dinarello CA, Moldawer LL. 2000. Pro-inflammatory and anti-inflammatory cytokines in rheumatoid arthritis, Chapter 1-4, Thousand Oaks (CA): AMGEN, Inc. pp 1-98.
11. Doyle LW, Crowther CA, Middleton P, Marret S. 2007. Magnesium sulphate for women at risk of preterm birth for neuro-protectionofthe fetus. Cochrane Database Syst Rev 3:CD004661.
12. Gadonski G, LaMarca BB, Sullivan E, Bennett W, Chandler D, Granger JP. 2006. Hypertension produced by reductions in uterine perfusion in the pregnant rat: role of interleukin 6. Hypertension 48:711-716.
13. Gosain A, Gamelli RL. 2005. A primer in cytokines. J Burn Care Rehabil 26:7-12.
14. Greer IA, Lyall F, Perera T, Boswell F, Macara LM. 1994. Increased concentrations of cytokines interleukin-6 and inter-leukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol 84:937-940.
15. Holcberg G, Amash A, Sapir O, Hallak M, Sheiner E, Ducler D, Katz M, Huleihel M. 2006. Different effects of magnesium sulfate and angiotensin II on the capacity of the fetal and maternal compartments of normal human placenta to secrete TNF-alpha and IL-6. J Reprod Immunol 69:115-125.
16. Holcberg G, Amash A, Sapir O, Sheiner E, Levy S, Huleihel M. 2007. Perfusion with lipopolysaccharide differently affects the secretion of tumor necrosis factor-alpha and interleukin-6 by term and preterm human placenta. J Reprod Immunol 74:15-23.
17. Holcberg G, Amash A, Sapir O, Sheiner E, Levy S, Myatt L, Huleihel M. 2008. Perfusion with lipopolysaccharide differently affects the secretion of interleukin-1 beta and interleukin-1 receptor antagonist by term and preterm human placentae. Placenta 29:593-601.
18. Holcberg G, Sapir O, Hallak M, Alaa A, Shorok HY, David Y, Katz M, Huleihel M. 2004. Selective vasodilator effect of magnesium sulfate in human placenta. Am J Reprod Immunol 51:192-197.
19. Kauma SW, Wang Y, Walsh SW. 1995. Preeclampsia is associated with decreased placental interleukin-6 production. J Soc Gynecol Investig 2:614-617.
20. Kuban KCK, Leviton A, Pagano M, Fenton T, Strasfeld R, Wolff M. 1992. Maternal toxemia is associated with reduced incidence of germinal matrix hemorrhage in premature babies. J Child Neurol 7:70-76.
21. Makhlouf MA, Simhan HN. 2006. Effect of tocolytics on inter-leukin-8 production by human amniotic and decidual cells. J Reprod Immunol 69:1-7.
22. Mutter WP, Karumanchi SA. 2008. Molecular mechanisms of preeclampsia. Microvasc Res 75:1-8.
23. Nakabayashi M, Sakura M, Takeda Y, Sato K. 1998. Elevated IL-6 in midtrimester amniotic fluid is involved with the onset of preeclampsia. Am J Reprod Immunol 39:329-334. (Pubitemid 28172231)
24. National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. 2000. Report of the national high blood pressure education program working program working group on high blood pressure in pregnancy. Am J Obstet Gynecol 183:S1-S22.
25. Nelson KB, Dambrosia JM, Grether JK, Phillips TM. 1998. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 44:665-675.
26. Nelson KB, Grether JK. 1995. Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants? Pediatrics 95:263-269.
27. Opsjon SL, Austgulen R, Waage A. 1995. Interleukin-1, inter-leukin-6 and tumor necrosis factor at delivery in preeclamptic disorders. Acta Obstet Gynecol Scand 74:19-26.
28. Redman CW, Sargent IL. 2005. Latest advances in understanding preeclampsia. Science 308:1592-1594.
29. Rochelson B, Dowling O, Schwartz N, Metz CN. 2007. Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFkappaB pathway. J Reprod Immunol 73:101-107.
30. Rusterholz C, Hahn S, Holzgreve W. 2007. Role of placentally produced inflammatory and regulatory cytokines in pregnancy and the etiology of preeclampsia. Semin Immunopathol 29:151-162.
31. Scardo JA, Hogg BB, Newman RB. 1995. Favorable hemody-namic effects of magnesium sulfate in preeclampsia. Am J Obstet Gynecol 173:1249-1253.
32. Sibai B, Caritis S, Hauth J. 2003. What we have learned about preeclampsia. Semin Perinatol 27:239-246.
33. Sibai B, Dekker G, Kupferminc M. 2005. Pre-eclampsia. Lancet 365:785-799.
34. Sibai BM. 2005. Magnesium sulfate prophylaxis in preeclampsia: evidence from randomized trials. Clin Obstet Gynecol 48: 478-488.
35. Soleymanlou N, Jurisica I, Nevo O, Ietta F, Zhang X, Zamudio S, Post M, Caniggia I. 2005. Molecular evidence of placental hypoxia in preeclampsia. J Clin Endocrinol Metab 90:4299-4308.
36. Sontia B, Touyz RM. 2007. Role of magnesium in hypertension. Arch Biochem Biophys 458:33-39.
37. Tolando R, Jovanovic A, Brigelius-Flohe R, Ursini F, Maiorino M. 2000. Reactive oxygen species and proinflammatory cyto-kine signaling in endothelial cells: effect of selenium supplementation. Free Radic Biol Med 28:979-986.
38. Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CW. 1995. Interleukin-6, tumour necrosis factor and soluble tumour necrosis factor receptors in women with pre-eclampsia. Br J Obstet Gynaecol 102:20-25.
39. Weglicki WB, Phillips TM, Freedman AM, Cassidy MM, Dickens BF. 1992. Magnesium-deficiency elevates circulating levels of inflammatory cytokines and endothelin. Mol Cell Biochem 110:169-173.
40. Wolf FI, Trapani V, Simonacci M, Ferré S, Maier JA. 2008. Magnesium deficiency and endothelial dysfunction: is oxida-tive stress involved? Magnes Res 21:58-64.
41. Yoon BH, Jun JK, Romero R, Park KH, Gomez R, Chio JH, Kim IO. 1997. Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy. Am J Obstet Gynecol 177:19-26.
42. Zhang J, Meikle S, Trumble A. 2003. Severe maternal morbidity associated with hypertensive disorders in pregnancy in the United States. Hypertens Pregnancy 22:203-212.