Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders

Journal of Medicinal Food

Volumn 13, Issue 5, 2010, Pages 1086-1096

  Mehmood, Malik Hassan ^a,b   Gilani, Anwarul Hassan ^a,c  

^a AGA KHAN UNIVERSITY MEDICAL COLLEGE   (Pakistan)

^b UNIVERSITY OF KARACHI   (Pakistan)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

antidiarrheal; antispasmodic; laxative; pepper; Piper nigrum; piperine; spasmodic

Indexed keywords

ATROPINE; BLACK PEPPER EXTRACT; CALCIUM ANTAGONIST; CALCIUM CHANNEL BLOCKING AGENT; CARBACHOL; LOPERAMIDE; NALOXONE; NIFEDIPINE; PIPERINE; POTASSIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLACK PEPPER; CONCENTRATION RESPONSE; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DRUG EFFECT; FEMALE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MOTILITY DISORDER; GUINEA PIG; ILEUM; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

ALKALOIDS; ANIMALS; ANTIDIARRHEALS; BENZODIOXOLES; BLACK PEPPER; CALCIUM CHANNEL BLOCKERS; CHOLINERGIC AGENTS; CONSTIPATION; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL DISEASES; GUINEA PIGS; ILEUM; JEJUNUM; LAXATIVES; MALE; MICE; MICE, INBRED BALB C; MUSCLE CONTRACTION; NALOXONE; PHYTOTHERAPY; PIPERIDINES; POLYUNSATURATED ALKAMIDES; RABBITS; RECEPTORS, OPIOID;

CAVIA; MUS; ORYCTOLAGUS CUNICULUS; PIPER NIGRUM;

EID: 77956584467     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2010.1065     Document Type: Article

References (54)

1. Grieve M, Leyel CF: The medicinal, culinary, cosmetic and economic properties, cultivation and folklore of herbs, grasses, fungi, shrubs and trees with all their modern scientific uses. In: A Modern Herbal. Tiger Books International, Mackays of Chatham, PLC, Chatham, UK, 1994, pp. 627-629.
2. nd ed. CRC Press, Boca Raton, FL, 2002, pp. 98-99.
3. Nadkarni KM: Piper nigrum L. In: Indian Materia Medica, Vol.1. Popular Prakashan Press, Bombay, 1986, pp. 969-972.
4. Usmanghani K, Saeed A, Alam MT: Piper nigrum L. In: In-dusyunic Medicine. University of Karachi Press, Karachi, Pakistan, 1997, pp. 344-345.
5. Aravind R., Kumar A, Eapen SJ, Ramana KV: Endophytic bacterial flora in root and stem tissues of black pepper (Piper nigrum L.) genotype: isolation, identification and evaluation against Phytophthora capsici. Lett Appl Microbiol 2009;48:58-64.
6. Hirata N, Naruto S, Inaba K, Itoh K, Tokunaga M, Iinuma M, Matsuda H: Histamine release inhibitory activity of Piper nigrum leaf. Biol Pharm Bull 2008;31:1973-1976.
7. Srinivasan K: Black pepper and its pungent principle\piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr 2007;47:735-748.
8. Kim SH, Lee YC: Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model. J Pharm Pharmacol 2009;61:353-359.
9. Bang JS, Oh DH, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS: Anti-inflammatory and antiar-thritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther 2009;11:R49.
10. Taqvi SIH, Shah AJ, Gilani AH: Blood pressure lowering and vasomodulator effects of piperine. J Cardiovasc Pharmacol 2008;52:452-458.
11. Bezerra DP, de Castro FO, Alves AP, Pessoa C, de Moraes MO, Silveira ER, Lima MA, Elmiro FJ, de Alencar NM, Mesquita RO, Lima MW, Costa-Lotufo LV: In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine. J Appl Toxicol 2008;28:156-163.
12. Matsuda D, Ohte S, Ohshiro T, Jiang W, Rudel L, Hong B, Si S, Tomoda H: Molecular target of piperine in the inhibition of lipid droplet accumulation in macrophages. Biol Pharm Bull 2008;31:1063-1066.
13. Das B, Kundu J, Bachar SC, Uddin MA, Kundu JK: Antitumor and antibacterial activity of ethylacetate extract of Ludwigia hyssopifolia L. and its active principle piperine. Pak J Pharm Sci 2007;20:128-131.
14. Gupta SK, Bansal P, Bhardwaj RK, Velpandian T: Comparative anti-nociceptive, anti-inflammatory and toxicity profile of ni-mesulide vs nimesulide and piperine combination. Pharmacol Res 200;41:657-662.
15. Naseri MK, Yahyavi H: Antispasmodic effect of Piper nigrum fruit hot water extract on rat ileum. Pak J Biol Sci 2008;11:1492-1496.
16. Takaki M, Jin JG, Lu YF, Nakayama S: Effects of piperine on the motility of the isolated guinea-pig ileum: comparison with cap-saicin. Eur J Pharmacol 1990;186:71-77.
17. Taqvi SIH, Shah AJ, Gilani AH: Insight into antidiarrheal and antispasmodic activities of piperine. Pharm Biol 2009;47:660-664.
18. Bajad S, Bedi KL, Singla AK, Johri RK: Antidiarrheal activity of piperine in mice. Planta Med 2001;67:284-287.
19. Capasso R, Izzo AA, Borrelli F, Russo A, Sautebin L, Pinto A, Capasso F, Mascolo N: Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice. Life Sci 2002;71:2311-2317.
20. McNamara FN, Randall A, Gunthorpe MJ: Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 2005;144:781-790.
21. Williamson EM, Okpako DT, Evans FJ: Selection, Preparation and Pharmacological Evaluation of Plant Material. John Wiley & Sons, Chichester, UK, 1998, pp. 15-23.
22. National Research Council: Guide for the Care and Use of Laboratory Animals. National Academies Press, Washington, 1997.
23. Ghayur MN, Gilani AH: Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Dig Dis Sci 2005;50:1889-1897.
24. Cosola C, Albrizio M, Guaricci AC, De Salvia MA, Zarrilli A, Sciorsci RL, Minoia R: Opioid agonist=antagonist effect of naloxone in modulating rabbit jejunum contractility in vitro. J Physiol Pharmacol 2006;57:439-449.
25. 2\+ antagonists. Gen Pharmacol 1991;22: 177-181.
26. Kadowaki M, Nagakura Y, Tomoi M, Mori J, Kohsaka M: Effect of FK1052, a potent 5-hydroxytryptamine-3 and 5-hydroxytryp-tamine-4 receptor dual antagonist, on colonic function in vivo. J Pharmacol Exp Ther 1993;266:74-80.
27. Santos FA, Rao VS: Quinine-induced inhibition of gastrointestinal transit in mice: possible involvement of endogenous opi-oids. Eur J Pharmacol 1999;364:193-197.
28. Piercey MF, Ruwart MJ: Naloxone inhibits the anti-diarrheal activity of loperamide. Br J Pharmacol 1979;66:373-375.
29. Arunlakshana O, Schild HO: Some quantitative uses of drug antagonists. Br J Pharmacol Chemother 1959;14:48-58.
30. th ed. (Brunton LL, Lazo JS, Parker KL, eds.). McGraw-Hill, New York, 2006, pp. 183-200.
31. Ghayur MN, Gilani AH, Houghton PJ: Species differences in the gut stimulatory effects of radish seeds. J Pharm Pharmacol 2005;57:1493-1501.
32. Platel K, Srinivasan K: Digestive stimulant action of spices: a myth or reality? Indian J Med Res 2004;119:167-179.
33. Platel K, Srinivasan K: Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung 2000;44:42-46.
34. th ed. (Brunton LL, Lazo JS, Parker KL, eds.). McGraw-Hill, New York, 2006, pp. 967-981.
35. Gilani AH, Shah AJ, Ghayur MN, Majeed K: Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sci 2005;76:3089-3105.
36. th ed. (Brunton LL, Lazo JS, Parker KL, eds.). McGraw-Hill, New York, 2006, pp. 547-590.
37. Vaccarino AL, Kastin AJ: Endogenous opiates. Peptides 2000; 22:2257-2328.
38. Wittert G, Hope P, Pyle D: Tissue distribution of opioid receptor gene expression in the rat. Biochem Biophys Res Commun 1996;218:877-881.
39. Burks TF, Fox DA, Hirning LD, Shook JE, Porreca F: Regulation of gastrointestinal function by multiple opioid receptors. Life Sci 1988;43:2177-2181.
40. 2\+ in the contractility of rabbit small intestine in vitro. J Physiol Pharmacol 2004;55:639-650.
41. Sandhu BK, Tripp JH, Candy DC, Harries JT: Loperamide: studies on its mechanism of action. Gut 1981;22:658-662.
42. Iwao I, Terada Y: On the mechanism of diarrhea due to castor oil. Jpn J Pharmacol 1962;12:137-145.
43. th ed. (Brunton LL, Lazo JS, Parker KL, eds.). McGraw-Hill, New York, 2006, pp. 983-1008.
44. 2\+ channels. Neurosci Res 2003;46:493-497.
45. Gupta SK, Bansal P, Bhardwaj RK, Velpandian T: Comparative anti-nociceptive, anti-inflammatory and toxicity profile of ni-mesulide vs nimesulide and piperine combination. Pharmacol Res 2002;41:657-662.
46. Akah PA, Oli AN, Enwerem NM, Gamaneil K: Preliminary studies on purgative effect of Carica papaya root extract. Fito-terapia 1997;68:327-331.
47. Baser KH: Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr Pharm Des 2008;14:3106-3119.
48. Duke JA: Piper nigrum L. In: Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants. CRC Press, Boca Raton, FL, 1992, pp. 464-466.
49. Kapoor IP, Singh B, Singh G, De Heluani CS, De Lampasona MP, Catalan CA: Chemistry and in vitro antioxidant activity of volatile oil and oleoresins of black pepper (Piper nigrum). J Agric Food Chem 2009;57:5358-5364.
50. Lee SW, Rho MC, Park HR, Choi JH, Kang JY, Lee JW, Kim K, Lee HS, Kim YK: Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum. J Agric Food Chem 2006;54:9759-9763.
51. Park IK, Lee SG, Shin SC, Park JD, Ahn YJ: Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species. J Agric Food Chem 2002;50:1866-1870.
52. Kanaki N, Dave M, Padh H, Rajani M: A rapid method for isolation of piperine from the fruits of Piper nigrum Linn. Nat Med 2008;62:281-283.
53. Gilani AH, Rahman AU: Trends in ethnopharmocology. J Eth-nopharmacol 2005;100:43-49.
54. 2\+ antagonist constituents in Saussurea lappa explains its use in constipation and spasm. Phytother Res 2007;21:541-544.