Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama)

Phytomedicine

Volumn 17, Issue 12, 2010, Pages 956-962

  Figueiro M ^a   Ilha, J ^a   Pochmann, D ^a   Porciuncula L O ^a   Xavier, L L ^b   Achaval, M ^a   Nunes, D S ^c   Elisabetsky, E ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^c STATE UNIVERSITY OF PONTA GROSSA   (Brazil)

Author keywords

Acetylcholinesterase inhibitors; Cognitive deficits; Marapuama; Neurodegenerative disorders; Ptychopetalum olacoides

Indexed keywords

CHOLINESTERASE INHIBITOR; GALANTAMINE; HERBACEOUS AGENT; NOOTROPIC AGENT; PTYCHOPETALUM OLACOIDES EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CHOLINERGIC TRANSMISSION; COGNITION; COLORIMETRY; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ACTIVITY; DRUG EFFICACY; DRUG SAFETY; ENZYME INHIBITION; FRONTAL CORTEX; HIPPOCAMPUS; HISTOCHEMISTRY; MALE; MARAPUAMA; MEDICINAL PLANT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PTYCHOPETALUM OLACOIDES; SINGLE DRUG DOSE; WESTERN BLOTTING;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; CHOLINESTERASE INHIBITORS; COGNITION; MALE; MICE; MICE, INBRED STRAINS; NEURODEGENERATIVE DISEASES; NOOTROPIC AGENTS; OLACACEAE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; PROTEIN ISOFORMS;

MUS; PTYCHOPETALUM OLACOIDES;

EID: 77956582271     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.03.009     Document Type: Article

References (45)

1. Amaral D.G., Witter M.P. The three-dimensional organization of the hippocampal formation: a review of anatomical data. Neuroscience 1989, 31:571-591.
2. Anekonda T.S., Reddy P.H. Can herbs provide a new generation of drugs for treating Alzheimer's disease?. Brain Res. Rev. 2005, 50:361-376.
3. Barnes C.A., Meltzer J., Houston F., Orr G., McGann K., Wenk G.L. Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors. Neuroscience 2000, 99:17-23.
4. Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217:408-417.
5. Bartus R.T. On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis. Exp. Neurol. 2000, 163:495-529.
6. Birks J., Flicker L. Donepezil for mild cognitive impairment. Cochrane Database Syst. Rev. 2006, 19(3):CD006104.
7. Colom L.V. Septal networks: relevance to theta rhythm, epilepsy and Alzheimer's disease. J. Neurochem. 2006, 96:609-623.
8. Coyle J.T., Price D.L., DeLong M.R. Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 1983, 219(4589):1184-1190.
9. Cunha R.A., Johansson B., Constantino M.D., Sebastião A.M., Fredholm B.B. Evidence for high-affinity binding sites for the adenosine A2A receptor agonist [3H]CGS 21680 in the rat hippocampus and cerebral cortex that are different from striatal A2A receptors. Naunyn Schmiedeberg's Arch. Pharmacol. 1996, 353:261-271.
10. da Silva A.L., Piato A.L., Bardini S., Netto C.A., Nunes D.S., Elisabetsky E. Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice. J. Ethnopharmacol. 2004, 95:199-203.
11. da Silva A.L., Piato A.L., Ferreira J.G., Martins B.S., Nunes D.S., Elisabetsky E. Promnesic effects of Ptychopetalum olacoides in aversive and non-aversive learning paradigms. J. Ethnopharmacol. 2007, 109:449-457.
12. da Silva A.L., Ferreira J.G., da Silva Martins B., Oliveira S., Mai N., Nunes D.S., Elisabetsky E. Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama). Physiol. Behav. 2008, 95(1-2):88-92.
13. da Silva A.L., Silva Martins B., Linck V., de M., Herrmann A.P., Mai N., Nunes D.S., Elisabetsky E. MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a " brain tonic" Psychopharmacology 2009, 202(1-3):165-172.
14. Das A., Dikshit M., Nath C. Profile of acetylcholinesterase in brain areas of male and female rats of adult and old age. Life Sci. 2001, 68:1545-1555.
15. Ellman G.L., Courtney K.D., Andre V., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 1961, 7:27-30.
16. Elisabetsky E., Siqueira I.R. Is there a psychopharmacological meaning for traditional tonics?. Plants for Food and Medicine 1998, 373-385. Royal Botanic Gardens, Kew, London. H.D. Prendergast, N. Etkin, D.R. Harris, P.J. Houghton (Eds.).
17. Francis P.T., Palmer A.M., Snape M., Wilcock G.K. The cholinergic hypothesis of Alzheimer's disease: a review of progress. J. Neurol. Neurosurg. Psychiatry 1999, 66:137-147.
18. Francotte P., Graindorge E., Boverie S., de Tullio P., Pirotte B. New trends in the design of drugs against Alzheimer's disease. Curr. Med. Chem. 2004, 11:1757-1778.
19. Franklin K.B.J., Paxinos G.T. The Mouse Brain in Stereotaxic Coordinates 1996, Academic Press, San Diego.
20. Karnovsky M.J., Roots L. A " direct-coloring" thiocoline method for cholinesterases. J. Histochem. Cytochem. 1964, 12:219-221.
21. Kosasa T., Kuriya Y., Matsui K., Yamanishi Y. Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats. Eur. J. Pharmacol. 1999, 386(1):7-13.
22. Lane R.M., Kivipelto M., Greig N.H. Acetylcholinesterase and its inhibition in Alzheimer disease. Clin. Neuropharmacol. 2004, 27:141-149.
23. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
24. Meier-Ruge W.A., Bruder E. Current concepts of enzyme histochemistry in modern pathology. Pathobiology 2008, 75:233-243.
25. Michalek H., Fortuna S., Volpe M.T., Pintor A. Age-related differences in the recovery rate of brain cholinesterases, choline acetyltransferase and muscarinic acetylcholine receptor sites after a subacute intoxication of rats with the anticholinesterase agent, isofluorophate. Acta Neurobiol. Exp. 1990, 50:237-249.
26. Moser E., Moser M.B., Andersen P. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci. 1993, 13:3916-3925.
27. Muir J.L. Acetylcholine, aging, and Alzheimer's disease. Pharmacol. Biochem. Behav. 1997, 56(4):687-696.
28. Pardridge W.M. Drug targeting to the brain. Pharm. Res. 2007, 24(9):1733-1744.
29. Pardridge W.M. Alzheimers's disease drug development and the problem of the blood-brain barrier. Alzheimers Dement. 2009, 5(5):427-432.
30. Perry E.K., Martin-Ruiz C.M., Court J.A. Nicotinic receptor subtypes in human brain related to aging and dementia. Alcohol 2001, 24(2):63-68.
31. Piato A.L., Detanico B.C., Jesus J.F., Lhullier F.L.R., Nunes D.S., Elisabetsky E. Effects of Marapuama in the chronic mild stress model: Further indication of antidepressant properties. J. Ethnopharmacol. 2008, 118(2):300-304.
32. Sarter M., Parikh V. Choline transporters, cholinergic transmission and cognition. Nat. Rev. Neurosci. 2005, 6:48-56.
33. Schegg K.M., Harrington L.S., Neilsen S., Zweig R.M., Peacock J.H. Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease. Neurobiol. Aging 1992, 13:697-704.
34. Schliebs R., Arendt T. The significance of the cholinergic system in the brain during aging and in Alzheimer's disease. J. Neural Transm. 2006, 113:1625-1644.
35. Siek G.C., Katz L.S., Fishman E.B., Korosi T.S., Marquis J.K. Molecular forms of acetylcholinesterase in subcortical areas of normal and Alzheimer disease brain. Biol. Psychiatry 1990, 27:573-580.
36. Siqueira I.R., Fochesatto C., da Silva A.L., Nunes D.S., Battastini A.M., Netto C.A., Elisabetsky E. Ptychopetalum olacoides, a traditional Amazonian " nerve tonic" , possesses anticholinesterase activity. Pharmacol. Biochem. Behav. 2003, 75:645-650.
37. Siqueira I.R., Cimarosti H., Fochesatto C., Nunes D.S., Salbego C., Elisabetsky E., Netto C.A. Neuroprotective effects of Ptychopetalum olacoides Bentham (Olacaceae) on oxygen and glucose deprivation induced damage in rat hippocampal slices. Life Sci. 2004, 75(15):1897-1906.
38. Siqueira I.R., Fochesatto C., Torres I.L.S., da Silva A.L., Nunes D.S., Elisabetsky E., Netto C.A. Antioxidant activities of Ptychopetalum olacoides (" muirapuama" ) in mice brain. Phytomedicine 2007, 14(11):763-769.
39. Sonkusare S.K., Kaul C.L., Ramarao P. Dementia of Alzheimer's disease and other neurodegenerative disorders-memantine, a new hope. Pharmacol. Res. 2005, 51:1-17.
40. Van Marum R.J. Current and future therapy in Alzheimer's disease. Fundam. Clin. Pharmacol. 2008, 22(3):265-274.
41. Whitehouse P.J., Price D.L., Clark A.W., Coyle J.T., DeLong M.R. Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann. Neurol. 1981, 10(2):122-126.
42. Whitehouse P.J., Price D.L., Struble R.G., Clark A.W., Coyle J.T., DeLong M.R. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1982, 215:1237-1239.
43. Winkelmann-Duarte E.C., Todeschin A.S., Fernandes M.C., Bittencourt L.C., Pereira G.A., Samios V.N., Schuh A.F., Achaval M.E., Xavier L.L., Sanvitto G.L., Mandarim-de-Lacerda C.A., Lucion A.B. Plastic changes induced by neonatal handling in the hypothalamus of female rats. Brain Res. 2007, 19:20-30.
44. Xavier L.L., Viola G.G., Ferraz A.C., Da Cunha C., Deonizio J.M., Netto C.A., Achaval M. A simple and fast densitometric method for the analysis of tyrosine hydroxylase immunoreactivity in the substantia nigra pars compacta and in the ventral tegmental area. Brain Res. Brain Res. Protoc. 2005, 16:58-64.
45. Zhao Q., Tang X.C. Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. Eur. J. Pharmacol. 2002, 455:101-107.