Synthesis of geminal difluorides by oxidative desulfurization- difluorination of alkyl aryl thioethers with halonium electrophiles in the presence of fluorinating reagents and its application for 18F- radiolabeling

Journal of Organic Chemistry

Volumn 75, Issue 18, 2010, Pages 6086-6095

  Hugenberg, Verena ^a   Wagner, Stefan ^b   Kopka, Klaus ^b   Schober, Otmar ^b   Schäfers, Michael ^a   Haufe, Günter ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DIFLUORIDE; ELECTROPHILES; GOOD YIELD; HALONIUM; OXIDATIVE DESULFURIZATION; RADIOCHEMICAL YIELD; RADIOLABELING; THIOETHERS;

ALKYLATION; DESULFURIZATION; FLUORINE; SYNTHESIS (CHEMICAL);

POSITRON EMISSION TOMOGRAPHY;

1,1 DIBROMO 1 FLUOROUNDECANE; 1,1 DIFLUORO 11 AMINOUNDECANE; 1,1 DIFLUORO 11 METHOXYUNDECANE; 1,1 DIFLUOROALKANE DERIVATIVE; 1,1 DIFLUOROUNDEC 2 YL (4 NITROPHENYL)THIOETHER; 1,1 DIFLUOROUNDECANE; 1,1,2 TRIFLUOROUNDEC 2 YL (4 NITROPHENYL)THIOETHER; 1,15 DIBROMO 1 FLUOROPENTADECANE; 1,3 DIBROMO 5,5 DIMETHYLHYDANTOIN; 1,5 DIBROMO 1 FLUOROPENTANE; 12 (2 BROMO 4 NITROPHENOXY) 1,1 DIFLUORODODECANE; 12 (2,6 DIBROMO 4 NITROPHENOXY) 1,1 DIFLUORODODECANE; 15 BROMO 1,1 DIFLUOROPENTADECANE; 4 CHLOROPHENYL (1 FLUOROUNDEC 1 YL)THIOETHER; 4 CHLOROPHENYL(11 BROMO 1 FLUORODODEC 1 YL)THIOETHER; 4 CHLOROPHENYL[12 (4 NITROPHENOXY) 1 FLUORODODEC 1 YL]THIOETHER; 4 TOLYL (1 FLUORO 11 METHOXYUNDEC 1 YL)THIOETHER; 5 BROMO 1,1 DIFLUOROPENTANE; ALKYL GROUP; BROMOFLUORIDE; DIFLUORIDE; ELECTROPHILE; FLUORIDE; FLUORINE 18; HALOGEN; HALONIUM; HYDANTOIN; METHYL 11 (4 CHLOROPHENYLTHIO) 11 FLUOROUNDECANOATE; METHYL 11 BROMO 11 FLUOROUNDECANOATE; SULFIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; DESULFURIZATION; FLUORINATION; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; PUMMERER REACTION; RADIOCHEMISTRY; SUBSTITUTION REACTION; SYNTHESIS;

FLUORINE RADIOISOTOPES; HALOGENATION; HYDROCARBONS, FLUORINATED; HYDROFLUORIC ACID; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PYRIDINES; STEREOISOMERISM; SULFIDES;

EID: 77956556566     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo100689v     Document Type: Article

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