Fructose as a carbon source induces an aggressive phenotype in MDA-MB-468 breast tumor cells

International Journal of Oncology

Volumn 37, Issue 3, 2010, Pages 615-622

  Monzavi Karbassi, Behjatolah ^a,c   Hine, R Jean ^b,c   Stanley, Joseph S ^a   Ramani, Vishnu Prakash ^a   Carcel Trullols, Jaime ^a   Whitehead, Tracy L ^a   Kelly, Thomas ^a,c   Siegel, Eric R ^a   Artaud, Cecile ^a   Shaaf, Saeid ^a   Saha, Rinku ^a   Jousheghany, Fariba ^a   Henry Tillman, Ronda ^a   Kieber Emmons, Thomas ^a,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Breast cancer; Fructose; Glycans; MDA MB 468 cells; Metastasis

Indexed keywords

F ACTIN; FRUCTOSE; GLUCOSE; GLYCAN; ISOLECTIN B4;

ARTICLE; BREAST TUMOR; CANCER CELL CULTURE; CARBON SOURCE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL STRUCTURE; CELL SURFACE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSKELETON; FUCOSYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; METASTASIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIALYLATION; STAINING;

ACTINS; BREAST NEOPLASMS; CARBON; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; FRUCTOSE; GLYCOSYLATION; HUMANS; MICROSCOPY, PHASE-CONTRAST; NEOPLASM INVASIVENESS; PHENOTYPE; PLANT LECTINS; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 77956555534     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000710     Document Type: Article

References (37)

1. Hakomori S: Tumor-associated carbohydrate antigens defining tumor malignancy: basis for development of anti-cancer vaccines. Adv Exp Med Biol 491: 369-402, 2001.
2. Couldrey C and Green JE: Metastases: the glycan connection. Breast Cancer Res 2: 321-323, 2000.
3. Gorelik E, Galili U and Raz A: On the role of cell surface carbohydrates and their binding proteins (lectins) in tumor metastasis. Cancer Metastasis Rev 20: 245-277, 2001.
4. Kawaguchi T: Cancer metastasis: characterization and identification of the behavior of metastatic tumor cells and the cell adhesion molecules, including carbohydrates. Curr Drug Targets Cardiovasc Haematol Disord 5: 39-64, 2005.
5. Lee RT, Lauc G and Lee YC: Glycoproteomics: protein modifications for versatile functions. Meeting on glycoproteomics. EMBO Rep 6: 1018-1022, 2005.
6. Berger V, Perier S, Pachiaudi C, Normand S, Louisot P and Martin A: Dietary specific sugars for serum protein enzymatic glycosylation in man. Metabolism 47: 1499-1503, 1998.
7. Delhotal B, Lemonnier F, Couturier M, Wolfrom C, Gautier M and Lemonnier A: Comparative use of fructose and glucose in human liver and fibroblastic cell cultures. In Vitro 20: 699-706, 1984. (Pubitemid 15166404)
8. Wolfrom C, Loriette C, Polini G, Delhotal B, Lemonnier F and Gautier M: Comparative effects of glucose and fructose on growth and morphological aspects of cultured skin fibroblasts. Exp Cell Res 149: 535-546, 1983.
9. Wolfrom C, Kadhom N, Raulin J, Raynaud N and Gautier M: Fructose-induced enhanced mitogenicity of diploid human cells: possible relationship with cell differentiation. In Vitro Cell Dev Biol Anim 30A: 263-268, 1994.
10. Medina RA and Owen GI: Glucose transporters: expression, regulation and cancer. Biol Res 35: 9-26, 2002.
11. Zamora-Leon SP, Golde DW, Concha, II, Rivas CI, Delgado-Lopez F, Baselga J, Nualart F and Vera JC: Expression of the fructose transporter GLUT5 in human breast cancer. Proc Natl Acad Sci USA 93: 1847-1852, 1996.
12. Grover-McKay M, Walsh SA, Seftor EA, Thomas PA and Hendrix MJ: Role for glucose transporter 1 protein in human breast cancer. Pathol Oncol Res 4: 115-120, 1998. (Pubitemid 28394627)
13. Enzmann H, Ohlhauser D, Dettler T and Bannasch P: Enhancement of hepatocarcinogenesis in rats by dietary fructose. Carcinogenesis 10: 1247-1252, 1989.
14. Yam D, Fink A, Nir I and Budowski P: Insulin-tumour interrelationships in thymoma bearing mice. Effects of dietary glucose and fructose. Br J Cancer 64: 1043-1046, 1991.
15. Stamp D, Zhang XM, Medline A, Bruce WR and Archer MC: Sucrose enhancement of the early steps of colon carcinogenesis in mice. Carcinogenesis 14: 777-779, 1993.
16. Godoy A, Ulloa V, Rodriguez F, Reinicke K, Yanez AJ, Garcia Mde L, Medina RA, Carrasco M, Barberis S, Castro T, Martinez F, Koch X, Vera JC, Poblete MT, Figueroa CD, Peruzzo B, Perez F and Nualart F: Differential subcellular distribution of glucose transporters GLUT1-6 and GLUT9 in human cancer: ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues. J Cell Physiol 207: 614-627, 2006.
17. Cailleau R, Olive M and Cruciger QV: Long-term human breast carcinoma cell lines of metastatic origin: preliminary characterization. In Vitro 14: 911-915, 1978. (Pubitemid 9089089)
18. Brinkley BR, Beall PT, Wible LJ, Mace ML, Turner DS and Cailleau RM: Variations in cell form and cytoskeleton in human breast carcinoma cells in vitro. Cancer Res 40: 3118-3129, 1980.
19. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S and Sanchez-Lozada LG: Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86: 899-906, 2007.
20. Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, Karaca G, Troester MA, Tse CK, Edmiston S, Deming SL, Geradts J, Cheang MC, Nielsen TO, Moorman PG, Earp HS and Millikan RC: Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295: 2492-2502, 2006.
21. Albini A, Benelli R, Noonan DM and Brigati C: The 'chemoinvasion assay': a tool to study tumor and endothelial cell invasion of basement membranes. Int J Dev Biol 48: 563-571, 2004. (Pubitemid 39360407)
22. Kelly T, Yan Y, Osborne RL, Athota AB, Rozypal TL, Colclasure JC and Chu WS: Proteolysis of extracellular matrix by invadopodia facilitates human breast cancer cell invasion and is mediated by matrix metalloproteinases. Clin Exp Metastasis 16: 501-512, 1998.
23. Sawada R, Tsuboi S and Fukuda M: Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials. J Biol Chem 269: 1425-1431, 1994.
24. Renkonen J, Paavonen T and Renkonen R: Endothelial and epithelial expression of sialyl Lewis(x) and sialyl Lewis(a) in lesions of breast carcinoma. Int J Cancer 74: 296-300, 1997. (Pubitemid 27321799)
25. Biancone L, Araki M, Araki K, Vassalli P and Stamenkovic I: Redirection of tumor metastasis by expression of E-selectin in vivo. J Exp Med 183: 581-587, 1996.
26. Paolini DHL, Gonzalez F, Colofiore J, Rossow P and Amos H: Sugar composition of mammalian cell surface membrane: a function of carbon source. In: Cell Surface Carbohydrate Chemistry. Harmon RE (ed). Academic Press, New York, 1978.
27. Mack DR, Cheng PW, Perini F, Wei S and Hollingsworth MA: Altered expression of sialylated carbohydrate antigens in HT29 colonic carcinoma cells. Glycoconj J 15: 1155-1163, 1998.
28. Malide D, Davies-Hill TM, Levine M and Simpson IA: Distinct localization of GLUT-1, -3, and -5 in human monocyte-derived macrophages: effects of cell activation. Am J Physiol 274: E516-E526, 1998. (Pubitemid 28155646)
29. Dennis JW, Granovsky M and Warren CE: Protein glycosylation in development and disease. Bioessays 21: 412-421, 1999.
30. Guillot J, Guerry M, Konska G, Caldefie-Chezet F, De Latour M and Penault-Llorca F: [Modification of glycoconjugates during the carcinogenesis: the case of mammary carcinomas]. Bull Cancer 91: 141-158, 2004.
31. Handerson T, Camp R, Harigopal M, Rimm D and Pawelek J: Beta1,6-branched oligosaccharides are increased in lymph node metastases and predict poor outcome in breast carcinoma. Clin Cancer Res 11: 2969-2973, 2005.
32. Guo HB, Lee I, Kamar M, Akiyama SK and Pierce M: Aberrant N-glycosylation of beta1 integrin causes reduced alpha5beta1 integrin clustering and stimulates cell migration. Cancer Res 62: 6837-6845, 2002.
33. Monzavi-Karbassi B, Whitehead TL, Jousheghany F, Artaud C, Hennings L, Shaaf S, Slaughter A, Korourian S, Kelly T, Blaszczyk-Thurin M and Kieber-Emmons T: Deficiency in surface expression of E-selectin ligand promotes lung colonization in a mouse model of breast cancer. Int J Cancer 117: 398-408, 2005.
34. Levi B and Werman MJ: Fructose and related phosphate derivatives impose DNA damage and apoptosis in L5178Y mouse lymphoma cells. J Nutr Biochem 14: 49-60, 2003. (Pubitemid 36143751)
35. Putnam J, Allshouse J and Kantor L: U.S. per capita food supply trends: more calories, refined carbohydrates and fats. Food Review 25: 2-15, 2002.
36. Vuilleumier S: Worldwide production of high-fructose syrup and crystalline fructose. Am J Clin Nutr 58: S733-S736, 1993.
37. Romieu I, Lazcano-Ponce E, Sanchez-Zamorano LM, Willett W and Hernandez-Avila M: Carbohydrates and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev 13: 1283-1289, 2004. (Pubitemid 39071550)