Determinants of exhaled nitric oxide levels (FeNO) in childhood atopic asthma: Evidence for neonatal respiratory distress as a factor associated with low FeNO levels

Journal of Asthma

Volumn 47, Issue 7, 2010, Pages 810-816

  Ricciardolo, Fabio L M ^a,b   Silvestri, Michela ^a   Pistorio, Angela ^a   Strozzi, Mariachiara M ^a   Tosca, Maria A ^a   Bellodi, Simona C ^a   Battistini, Elena ^a   Gardella, Chiara ^a   Rossi, Giovanni A ^a  

^a G GASLINI INSTITUTE   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

bronchial asthma; eosinophilia; newborn; nitric oxide; respiratory distress syndrome; risk factors

Indexed keywords

ALLERGEN; CORTICOSTEROID; IMMUNOGLOBULIN E; NITRIC OXIDE;

ADOLESCENT; ALLERGIC ASTHMA; ANAMNESIS; ANTIGEN SPECIFICITY; ARTICLE; ASTHMA; CAT; CHEMOLUMINESCENCE; CHILD; CHILDHOOD DISEASE; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; CORTICOSTEROID THERAPY; DERMATOPHAGOIDES; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; EOSINOPHIL COUNT; EXPIRED AIR; FEMALE; FORCED EXPIRATORY VOLUME; GRASS POLLEN; HOUSE DUST ALLERGY; HUMAN; HYPERSENSITIVITY; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NEONATAL RESPIRATORY DISTRESS SYNDROME; PRICK TEST; RECEIVER OPERATING CHARACTERISTIC; RISK FACTOR; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; SPIROMETRY; ANIMAL; BLOOD; BREATH ANALYSIS; EXHALATION; IMMUNOLOGY; METABOLISM; NEWBORN; PYROGLYPHIDAE; STATISTICAL MODEL;

ADOLESCENT; ANIMALS; ASTHMA; BREATH TESTS; CHILD; EXHALATION; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; IMMUNOGLOBULIN E; INFANT, NEWBORN; LOGISTIC MODELS; MALE; NITRIC OXIDE; PYROGLYPHIDAE; RESPIRATORY DISTRESS SYNDROME, NEWBORN;

EID: 77956554544     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.3109/02770903.2010.489245     Document Type: Article

References (46)

1. Ricciardolo F, Sterk P, Gaston B, Folkerts G. Nitric oxide in health and disease of the respiratory system. Physiol Rev 2004; 84:731-765.
2. Ricciardolo FL, Di Stefano A, Sabatini F, Folkerts G. Reactive nitrogen species in the respiratory tract. Eur J Pharmacol 2006; 533:240-252.
3. Sacco O, Sale R, Silvestri M, Serpero L, Sabatini F, Raynal ME, Biraghi M, Rossi GA. Total and allergen-specific IgE levels in serum reflect blood eosinophilia and fractional exhaled nitric oxide concentrations but not pulmonary functions in allergic asthmatic children sensitized to house dust mites. Pediatr Allergy Immunol 2003; 14:475-481.
4. Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, Morgan WJ, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 2008; 372:1065-1072.
5. De Jongste JC, Carraro S, Hop WC, CHARISM Study Group, Baraldi E. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med 2009 15;179:93-97.
6. Yates DH, Kharitonov SA, Thomas PS, Barnes PJ. Endogenous nitric oxide is decreased in asthmatic patients by an inhibitor of inducible nitric oxide synthase. Am J Respir Crit Care Med. 1996;154:247-250.
7. Hoyt JC, Robbins RA, Habib M, Springall DR, Buttery LD, Polak JM, Barnes PJ. Cigarette smoke decreases inducible nitric oxide synthase in lung epithelial cells. Exp Lung Res 2003; 29:17-28.
8. Proud D. Nitric oxide and the common cold. Curr Opin Allergy Clin Immunol 2005;5:37-42.
9. De Gouw HW, Grünberg K, Schot R, Schot R, Kroes AC, Dick EC, Sterk PJ. Relationship between exhaled nitric oxide and airway hyperresponsive-ness following experimental rhinovirus infection in asthmatic subjects. Eur Respir J 1998;11:126-132.
10. Konno S, Hizawa N, Yamaguchi E, Jinushi E, Nishimura M. (CCTTT)n repeat polymorphism in the NOS2 gene promoter is associated with atopy. J Allergy Clin Immunol 2001; 108:810-814.
11. Baraldi E, Bonetto G, Zacchello F, Filippone M. Low exhaled nitric oxide in school-age children with bronchopulmonary dysplasia and airflow limitation. Am J Respir Crit Care Med 2005; 171:68-72.
12. National Heart, Lung and Blood Inititute. Global Strategy for Asthma Management and Prevention: Global Initiative for Asthma. Bethesda, MD: National Institute of Health, 2002. NIH publication no.02 3659.
13. Cole TJ. The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990; 44:45-60.
14. World Health Organization. WHO Child Growth Standards: Length/Height-for-Age, Weight-for-Age, Weight-for-Length, Weight-for-Height and Body Mass Index-for-Age: Methods and Development. Geneva: World Health Organization, 2006. Available at: www.who.int/childgrowth/from February 2010.
15. Silvestri M, Sabatini F, Spallarossa D, Fregonese L, Battistini E, Biraghi MG, Rossi GA. Exhaled nitric oxide levels in non-allergic and allergic mono-or polysensitised children with asthma. Thorax 2001; 56:857-862.
16. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al.; ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J 2005; 26:319-338.
17. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report of Working Party StandardizationofLung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16:5-40.
18. Recommendations for standardized procedures for the on-line and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children\1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med 1999; 160:2104-2117.
19. Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, Silkoff PE, Bisgaard H. Measurements of exhaled nitric oxide in healthy subjects age 4 to 17 years. J Allergy Clin Immunol 2005; 115:1130-1136.
20. Smith A, Cowan J, Filsell S, McLachlan C, Monti-Sheehan G, Jackson P, Taylor DR. Diagnosing asthma: comparisons between exhaled nitric oxide measurements and conventional tests. Am J Respir Crit Care Med 2004; 169:473-478.
21. Glas A, Lijmer J, Prins M, Bonsel GJ, Bossuyt PM. The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol 2003; 56:1129-1135.
22. Avital A, Uwyyed K, Berkman N, Bar-Yishay E, Godfrey S, Springer C. Exhaled nitric oxide is age-dependent in asthma. Pediatr Pulmonol 2003; 36:433-438.
23. Silvestri M, Spallarossa D, Frangova Yourukova V, Battistini E, Fregonese B, Rossi GA. Orally exhaled nitric oxide levels are related to the degree of blood eosinophilia in atopic children with mild-intermittent asthma. Eur Respir J 1999; 13:321-326.
24. Raju TN. Epidemiology of late preterm (near-term) births. Clin Perinatol 2006; 33:751-763.
25. LassusP,TuranlahtiM,Heikkilä P, Andersson LC, NupponenI,Sarnesto A, Andersson S. Pulmonary vascular endothelial growth factor and Flt-1 in fetuses, in acute and chronic lung disease, and in persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med. 2001; 164:1981-1987.
26. Shaul P, Afshar S, Gibson L, Sherman TS, Kerecman JD, Grubb PH, Yoder BA, McCurnin DC. Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung. Am J Physiol Lung Cell Mol Physiol 2002; 283:L1192-L1199.
27. Lim S, Jatakanon A, John M, Gilbey T, O'connor BJ, Chung KF, Barnes PJ. Effect of inhaled budesonide on lung function and airway inflammation. Assessment by various inflammatory markers in mild asthma. Am J Respir Crit Care Med 1999; 159:22-30.
28. Gibson P, Henry R, Thomas P. Noninvasive assessment of airway inflammation in children: induced sputum, exhaled nitric oxide, and breath condensate. Eur Respir J 2000; 16:1008-1015.
29. Payne D, Adcock I, Wilson N, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med 2001; 164:1376-1381.
30. Del Pozo V, de Arruda-Chaves E, de Andrés B, Cárdaba B, López-Farré A, Gallardo S, et al. Eosinophils transcribe and translate messenger RNA for inducible nitric oxide synthase. J Immunol 1997; 158:859-864.
31. Paoliello-Paschoalato A, Oliveira S, Cunha F. Interleukin 4 induces the expression of inducible nitric oxide synthase in eosinophils. Cytokine 2005; 30:116-124.
32. Beauvais F, Joly F. Effects of nitric oxide on the eosinophil survival in vitro. A role for nitrosyl-heme. FEBS Lett 1999; 443:37-40.
33. Truyen E, Coteur L, Dilissen E, Overbergh L, Dupont LJ, Ceuppens JL, Bullens DM. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax 2006; 61:202-208
34. Thomazzi S, Ferreira H, Conran N, De Nucci G, Antunes E. Role of nitric oxide on in vitro human eosinophil migration. Biochem Pharmacol 2001; 62:1417-1421.
35. Trifilieff A, Fujitani Y, Mentz F, Dugas B, Fuentes M, Bertrand C. In-ducible nitric oxide synthase inhibitors suppress airway inflammation in mice through down-regulation of chemokine expression. J Immunol 2000; 165:1526-1533.
36. Huang F, Niedbala W, Wei X, Xu D, Feng GJ, Robinson JH, Lam C, Liew FY. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur J Immunol 1998; 28:4062-4070.
37. Chang R, Feng M, Liu W, Lai MZ. Nitric oxide increased interleukin-4 expression in T lymphocytes. Immunology 1997; 90:364-369.
38. Batra J, Pratap Singh T, Mabalirajan U, Sinha A, Prasad R, Ghosh B. Association of inducible nitric oxide synthase with asthma severity, total serum immunoglobulin E and blood eosinophil levels. Thorax 2007; 62:16-22.
39. Leuppi J, Downs S, Downie S, Marks GB, Salome CM. Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms. Thorax 2002; 57:518-523.
40. Jouaville LF, Annesi-Maesano I, Nguyen LT, Bocage AS, Bedu M, Cail-laud D. Interrelationships among asthma, atopy, rhinitis and exhaled nitric oxide in a population-based sample of children. Clin Exp Allergy 2003; 33:1506-1511.
41. van Amsterdam J, Janssen N, de Meer G, Fischer PH, Nierkens S, van LoverenH, Opperhuizen A,Steerenberg PA, BrunekreefB.The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children. Clin Exp Allergy 2003; 33:187-191.
42. Saito J, Inoue K, Sugawara A, Yoshikawa M, Watanabe K, Ishida T, Ohtsuka Y, Munakata M. Exhaled nitric oxide as a marker of airway inflammation for an epidemiologic study in schoolchildren. J Allergy Clin Immunol 2004; 114:512-516.
43. Silvestri M, Sabatini F, Sale R, Defilippi AC, Fregonese L, Battistini E, Biraghi MG, Rossi GA. Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals. Pediatr Pulmonol 2003; 35:358-363.
44. Wilson N, James A, Uasuf C, Payne DN, Hablas H, Agrofioti C, Bush A. Asthma severity and inflammation markers in children. Pediatr Allergy Immunol 2001; 12:125-132.
45. Strunk R, Szefler S, Phillips B, Zeiger RS, Chinchilli VM, Larsen G, Hodg-don K, Morgan W, Sorkness CA, Lemanske RF Jr; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in children. J Allergy Clin Immunol 2003; 112:883-892
46. Mappa L, Cardinale F, Camodeca R, Tortorella ML, Pietrobelli A, Armenio L, Boner AL. Exaled nitric oxide and air trapping correlation in asthmatic children. Allergy 2005; 60:1436-1439.