Smad4 mediates malignant behaviors of human ovarian carcinoma cell through the effect on expressions of E-cadherin, plasminogen activator inhibitor-1 and VEGF

BMB Reports

Volumn 43, Issue 8, 2010, Pages 554-560

  Chen, Chen ^a,b   Sun, Ming Zhong ^a   Liu, Shuqing ^a   Yeh, Dongmei ^a,b   Yu, Lijun ^a   Song, Yang ^a   Gong, Linlin ^a   Hao, Lihong ^a   Hu, Jun ^a   Shao, Shujuan ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY   (China)

Author keywords

Invasion; Ovarian cancer; Progression; Smad4; Tumor metastasis

Indexed keywords

EID: 77956535594     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2010.43.8.554     Document Type: Article

References (30)

1. Ouyang, G., Yao, L., Ruan, K., Song, G., Mao, Y. and Bao, S. (2009) Genistein induces G2/M cell cycle arrest and apoptosis of human ovarian cancer cells via activation of DNA damage checkpoint pathways. Cell Biol. Int. 33, 1237-1244.
2. Zhang, Y., Ba, Y., Liu, C., Sun, G., Ding, L., Gao, S., Hao, J., Yu, Z., Zhang, J. and Zen, K. (2007) PGC-1alpha induces apoptosis in human epithelial ovarian cancer cells through a PPARgamma-dependent pathway. Cell Res. 17, 363-373.
3. Jemal, A., Thomas, A., Murray, T. and Thun, M. (2002) Cancer statistics, 2002. CA. Cancer J. Clin. 52, 23-47.
4. Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K. and Liebman, M. N. (2003) Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N. Engl. J. Med. 348, 203-213.
5. Wooster, R. and Weber, B. L. (2003) Breast and ovarian cancer. N. Engl. J. Med. 348, 2339-2347.
6. Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H. and Kern, S. E. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350-353.
7. Inman, G. J., Nicolas, F. J. and Hill, C. S. (2002) Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Mol. Cell 10, 283-294.
8. Moustakas, A., Souchelnytskyi, S. and Heldin, C. H. (2001) Smad regulation in TGF-beta signal transduction. J. Cell Sci. 114, 4359-4369.
9. Muller, N., Reinacher-Schick, A., Baldus, S., van Hengel, J., Berx, G., Baar, A., van Roy, F., Schmiegel, W. and Schwarte-Waldhoff, I. (2002) Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells. Oncogene 21, 6049-6058.
10. Losi, L., Bouzourene, H. and Benhattar, J. (2007) Loss of Smad4 expression predicts liver metastasis in human colorectal cancer. Oncol. Rep. 17, 1095-1099.
11. Zhao, S., Venkatasubbarao, K., Lazor, J. W., Sperry, J., Jin, C., Cao, L. and Freeman, J. W. (2008) Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res. 68, 4221-4228.
12. Ke, Z., Zhang, X., Ma, L. and Wang, L. (2008) Expression of DPC4/Smad4 in non-small-cell lung carcinoma and its relationship with angiogenesis. Neoplasia 55, 323-329.
13. Sunde, J. S., Donninger, H., Wu, K., Johnson, M. E., Pestell, R. G., Rose, G. S., Mok, S. C., Brady, J., Bonome, T. and Birrer, M. J. (2006) Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer. Cancer Res. 66, 8404-8412.
14. Shenhua, X., Lijuan, Q., Hanzhou, N., Xinghao, N., Chihong, Z., Gu, Z., Weifang, D. and Yongliang, G. (1999) Establishment of a highly metastatic human ovarian cancer cell line (HO-8910PM) and its characterization. J. Exp. Clin. Cancer Res. 18, 233-239.
15. Shi, J., Wan, Y. and Di, W. (2008) Effect of hypoxia and re-oxygenation on cell invasion and adhesion in human ovarian carcinoma cells. Oncol. Rep. 20, 803-807.
16. Chen, H., Yang, W. W., Wen, Q. T., Xu, L. and Chen, M. (2009) TGF-beta induced fibroblast activation protein expression, fibroblast activation protein expression increases the proliferation, adhesion, and migration of HO-8910PM. Exp. Mol. Pathol. 87, 187-194.
17. Dai, L., Gu, L., Ding, C., Qiu, L. and Di, W. (2009) TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression. Cancer Lett. 283, 159-167.
18. Ma, W., Yu, H., Wang, Q., Bao, J., Yan, J. and Jin, H. (2004) In vitro biological activities of transmembrane superantigen staphylococcal enterotoxin A fusion protein. Cancer Immunol. Immunother. 53, 118-124.
19. Sun, H., Sun, C. and Pan, Y. (2005) Cytotoxic activity and constituents of the volatile oil from the roots of Patrinia scabra Bunge. Chem. Biodivers. 2, 1351-1357.
20. Zhang, Y. B., Peng, X. Y. and Sun, H. X. (2008) A new cytotoxic, apoptosis-inducing triterpenoid from the rhizomes of Astilbe chinensis. Chem. Biodivers. 5, 189-196.
21. Sahai, E. (2005) Mechanisms of cancer cell invasion. Curr. Opin. Genet. Dev. 15, 87-96.
22. Kemler, R. (1993) From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. Trends Genet. 9, 317-321.
23. Shapiro, L., Fannon, A. M., Kwong, P. D., Thompson, A., Lehmann, M. S., Grubel, G., Legrand, J. F., Als-Nielsen, J., Colman, D. R. and Hendrickson, W. A. (1995) Structural basis of cell-cell adhesion by cadherins. Nature 374, 327-337.
24. Benest, A. V. and Augustin, H. G. (2009) Cancer: blood vessels kept quiet. Nature 458, 41-42.
25. Crawford, Y. and Ferrara, N. (2009) VEGF inhibition: insights from preclinical and clinical studies. Cell Tissue. Res. 335, 261-269.
26. Jain, R. K. (2009) A new target for tumor therapy. N. Engl. J. Med. 360, 2669-2671.
27. Gutierrez, L. S., Schulman, A., Brito-Robinson, T., Noria, F., Ploplis, V. A. and Castellino, F. J. (2000) Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Res. 60, 5839-5847.
28. Healy, A. M. and Gelehrter, T. D. (1994) Induction of plasminogen activator inhibitor-1 in HepG2 human hepatoma cells by mediators of the acute phase response. J. Biol. Chem. 269, 19095-19100.
29. Illemann, M., Bird, N., Majeed, A., Laerum, O. D., Lund, L. R., Dano, K. and Nielsen, B. S. (2009) Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. Int. J. Cancer 124, 1860-1870.
30. Van den Eynden, G. G., Van Laere, S. J., van der Auwera, I., Trinh, X. B., Van Marck, E. A., Dirix, L. Y. and Vermeulen, P. B. (2009) Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. Int. J. Cancer 125, 1494-1496.