Direct-to-Consumer Genetic and Genomic Testing: Preparing Nurse Practitioners for Genomic Healthcare

Journal for Nurse Practitioners

Volumn 6, Issue 8, 2010, Pages 585-594

  Loud, Jennifer T ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Direct to consumer marketing; Nurse practitioner; Personal genetic testing; Personal genomic testing

Indexed keywords

EID: 77956532760     PISSN: 15554155     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nurpra.2010.06.007     Document Type: Article

References (39)

1. McGuire AL, Burke W An unwelcome side effect of direct-to-consumer personal genome testing: raiding the medical commons. JAMA 2008, 300:2669-2671.
2. Caulfield T, Ries NM, Ray PN, Shuman C, Wilson B Direct-to-consumer genetic testing: good, bad or benign?. Clin Genet 2009, 77:101-105.
3. Manolio TA, Brooks LD, Collins FS A hapmap harvest of insights into the genetics of common diseases. J Clin Invest 2008, 18:1590-1605.
4. Feero WG, Guttmacher AE, Collins FS The genome gets personal, almost. JAMA 2008, 299:1351-1352.
5. Feero WG, Guttmacher AE, Collins FS Genomic Medicine - An updated primer. N Engl J Med 2010, 362:2001-2011.
6. Genetics Through a Primary Care Lens: A Web-Based Resource for Faculty Development Accessed December 30, 2009. http://staff.washington.edu/sbtrini/index.shtml.
7. Jorde LG, Carey JC, Bamshad MJ Medical Genetics 2010, Mosby/Elsevier, Philadelphia. 4th ed.
8. Khoury MJ, McBride C, Schully SD, Ioannidis JPA, Feero WG, Janssens ACJW, Gwinn M, et al. The scientific foundation for personal genomics: recommendations from a National Institutes of Health/Centers For Disease Control and Prevention multidisciplinary workshop. Genet Med 2009, 11:1-9.
9. Genetic Home Reference What is direct-to-consumer genetic testing? Accessed September 25, 2009. http://ghr.nlm.nih.gov/handbook/testing/directtoconsumer.
10. Hogarth S, Javit G, Melzer D The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues. Annu Rev Genomics Hum Genet 2008, 9:161-182.
11. Secretary's Advisory Committee on Genetics, Health & Society U.S. System of oversight of genetic testing: A response to the charge of the Health & Human Services Accessed September 25, 2009. http://www4.od.nih.gov/oba/SACGHS/reports/SACGHS_oversight_report.pdf.
12. Hudson K, Javitt G, Burke W, Byers P ASHG statement on direct-to-consumer genetic testing in the United States. Ob Gynec 2007, 110:1392-1395.
13. Zhou SF, Di YM, Chan E, Du YM, Chow VDW, Xue CC, et al. Clinical pharmocogenetics and potential application in personalized medicine. Cur Drug Metab 2008, 9:738-784.
14. Bowen DJ, Harris J, Jorgensen CM, Myers MF, Kuniyuka A Socioeconomic influences on the effects of a genetic testing direct-to-consumer marketing campaign. Public Health Genomics 2010, 13(3):131-142.
15. Goddard KA, Duquette D, Zlot A, et al. Public awareness and use of direct-to-consumer genetics tests: results from 3 state population-based survey, 2006. Am J Public Health 2009, 99(3):442-445.
16. Berg C, Fryer-Edward K The ethical challenges of direct-to-consumer genetic testing. J Bus Ethics 2008, 77:17-31.
17. Public Health Genomics Genomic translation: ACCE Process model for evaluating genetic test Accessed September 25, 2009. http://www.cdc.gov/genomics/gtesting/ACCE/index.htm.
18. Hunter DJ, Khoury MJ, Drazen JM Letting the genome out of the bottle: will we get our wish?. N Engl J Med 2008, 358:105-107.
19. National Cancer Institute. Genetics Overview (PDQ) 2008. Available at: and Accessed November 23, 2009. http://www.cancer.gov/cancertopics/pdq/genetics/risk-assessment-and-counseling/HealthProfessional/page4#Section_188.
20. Genetics & Public Policy Center Direct-to-Consumer genetic testing: Empowering or endangering the public? 2008b, May 30 Accessed September 25, 2009. http://www.dnapolicy.org/policy.issue.php?action=detail&issuebrief_id=32.
21. US Food and Drug Administration In Vitro Diagnostics Accessed June 15, 2010. http://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/InVitroDiagnostics/default.htm.
22. Oncology Nursing Society The role of the oncology nurse in cancer genetic counseling Accessed November 23, 2009. http://www.ons.org/publications/positions/documents/pdfs/CancerGenetic.pdf.
23. International Society of Nurses in Genetics Provision of quality genetic services and care: building a multidisciplinary, collaborative approach among genetic nurses and genetic counselors Accessed November 23, 2009. http://www.isong.org/about/ps_multidisciplinarygeneticcare.cfm.
24. Badzek L, Turner M, Jenkins JF Genomics and nursing practice: advancing the nursing profession. OJIN 2008, 13. Accessed June 6, 2010. http://www.nursingworld.org/MainMenuCategories/ANAMarketplace/ANAPeriodicals/OJIN/TableofContents/vol132008/No1Jan08/GenomicsandAdvancingNursing.
25. American Nurses Association Essentials of genetic and genomic nursing: competencies, curricula guidelines and outcome indicators 2008, The Association, Silver Spring, MD. second edition.
26. Ameer B, Krivoy N Direct-to-consumer/patient advertising of genetic testing: a position statement of the American college of clinical pharmacology. J Clin Pharmacol 2009, 29:886-888.
27. Robson ME, Storm CD, Weitzel J, Willims DS, Offit K American Society of Clinical Oncology Policy Update: genetic and genomic testing for cancer susceptibility. J Clin Onc 2010, 28(5):893-901.
28. Gail MH, Brinton LA, Byar DP, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst 1989, 81:1879-1886.
29. Gail MH Value of adding single-nucleotide polymorphism genotypes to a breast cancer risk model. J Natl Cancer Inst 2009, 10(13):959-963.
30. Easton DF, Pooley KA, Dunning AM, Pharoah PDP, Thompson D, Ballinger DG, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007, 447(7148):1087-1095.
31. Stacey SN, Manolescu A, Sulem P, Rafnar T, Gudmundsson J, Gudjonsson SA, et al. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nature Genetics 2007, 39(7):865-869.
32. Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, et al. A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet 2007, 39(3):352-358.
33. Pushkarev D, Neff NF, Quake SR Single-molecule sequencing of an individual human genome. Nat Biotech 2009, 27(9):847-850.
34. Bentley DR, Balasubramanian S, Swerdlow HP, et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 2008, 456:53-59.
35. Levy S, Sutton G, Ng PC, Feuk L, et al. The diploid genome sequence of an individual. PloS Biol 2007, e254.
36. Wang J, Wang W, Li R, et al. The diploid genome sequence of an Asian individual. Nature 2008, 456:60-65.
37. Wheeler DA, Srinivasan M, Egholm M, et al. The complete genome of an individual by massively parallel DNA sequencing. Nature 2008, 452:872-876.
38. National Human Genome Research Institute The 1000 Genome Project Accessed June 7, 2010. http://www.genome.gov/27528684.
39. Biesecker LG, Mullikin JC, Facio FM, Turner C, Cherukuri PF, Blakesley RW, et al. The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res 2009, 19(9):1665-1674.