1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 16, 2010, Pages 8988-8993

  Wang, Ran Juh ^a,b   Yang, Chun Hung ^c   Hu, Miao Lin ^b  

^a FISHERIES RESEARCH INSTITUTE   (Taiwan)

^b NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^c TAIWAN AGRICULTURAL CHEMICALS AND TOXIC SUBSTANCES RESEARCH INSTITUTE   (Taiwan)

Author keywords

1 Deoxynojirimycin (1 DNJ); Antimetastatic potential; Cell surface glycosylation; Matrix metalloproteinases 2 and 9

Indexed keywords

ANTIMETASTATIC POTENTIAL; BINDING MOTIF; CELL SURFACE GLYCOSYLATION; CELL SURFACES; CELL-MATRIX ADHESION; CIS-PLATIN; DEOXYNOJIRIMYCIN; FLOW-CYTOMETRIC ANALYSIS; IMINOSUGARS; MATRIX METALLOPROTEINASES; MATRIX METALLOPROTEINASES-2 AND -9; MELANOMA CELLS; METALLOPROTEINASES; MRNA EXPRESSION; SIALYLATION; TISSUE INHIBITOR;

ADHESION; BLOOD VESSELS; CELL ADHESION; DERMATOLOGY; ESTERIFICATION; GLYCOSYLATION; NUCLEIC ACIDS; ONCOLOGY; PLATINUM COMPOUNDS;

CELL MEMBRANES;

1 DEOXYNOJIRIMYCIN; GELATINASE A; GELATINASE B; MESSENGER RNA; PRIMER DNA; TISSUE INHIBITOR OF METALLOPROTEINASE;

ANIMAL; ARTICLE; CELL MEMBRANE; ENZYMOLOGY; EXPERIMENTAL MELANOMA; GENETICS; GLYCOSYLATION; METABOLISM; METASTASIS; MOUSE; NUCLEOTIDE SEQUENCE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

1-DEOXYNOJIRIMYCIN; ANIMALS; BASE SEQUENCE; CELL MEMBRANE; DNA PRIMERS; GLYCOSYLATION; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MELANOMA, EXPERIMENTAL; MICE; NEOPLASM METASTASIS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASES;

MORUS (ANGIOSPERM);

EID: 77956529132     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf101401b     Document Type: Article

References (29)

1. Yamazaki, D.; Kurisu, S.; Takenawa, T. Regulation of cancer cell motility through actin reorganization. Cancer Sci. 2005, 96 (7), 379-386.
2. Westermarck, J.;Kahari, V. M. Regulation ofmatrixmetalloproteinase expression in tumor invasion. FASEB J. 1999, 13 (8), 781-792.
3. Hofmann, U. B.; Westphal, J. R.; Van Muijen, G. N.; Ruiter, D. J. Matrix metalloproteinases in human melanoma. J. Invest. Dermatol. 2000, 115 (3), 337-344.
4. Hofmann, U. B.; Eggert, A. A.; Blass, K.; Brocker, E. B.; Becker, J. C. Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation. Cancer Res. 2003, 63 (23), 8221-8225.
5. Gohji, K.; Fujimoto, N.; Fujii, A.; Komiyama, T.; Okawa, J.; Nakajima, M. Prognostic significance of circulating matrix metalloproteinase- 2 to tissue inhibitor of metalloproteinases-2 ratio in recurrence of urothelial cancer after complete resection. Cancer Res. 1996, 56 (14), 3196-3198.
6. El-Shabrawi, Y.; Ardjomand, N.; Radner, H. MMP-9 is predominantly expressed in epithelioid and not spindle cell uveal melanoma. J. Pathol. 2001, 194 (2), 201-206.
7. Humphries, M. J.; Matsumoto, K.; White, S. L.; Olden, K. Inhibition of experimental metastasis by castanospermine in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitors. Cancer Res. 1986, 46 (10), 5215-5222.
8. Nakahara, S.; Raz, A. Biological modulation by lectins and their ligands in tumor progression and metastasis. Anticancer Agents Med. Chem. 2008, 8 (1), 22-36.
9. Hedlund, M.; Ng, E.; Varki, A.; Varki, N. M. R-2,6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo. Cancer Res. 2008, 68 (2), 388-394.
10. Chang, W. W.; Yu, C. Y.; Lin, T. W.; Wang, P. H.; Tsai, Y. C. Soyasaponin I decreases the expression of R-2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells. Biochem. Biophys. Res. Commun. 2006, 341 (2), 614-619.
11. Dennis, J. W.; Laferte, S. Tumor cell surface carbohydrate and the metastatic phenotype. Cancer Metastasis Rev. 1987, 5 (3), 185-204.
12. Cao, Y.; Merling, A.; Crocker, P. R.; Keller, R.; Schwartz-Albiez, R. Differential expression of â-galactoside R-2,6 sialyltransferase and sialoglycans in normal and cirrhotic liver and hepatocellular carcinoma. Lab. Invest. 2002, 82 (11), 1515-1524.
13. Nakagawa, K.; Kubota, H.; Kimura, T.; Yamashita, S.; Tsuzuki, T.; Oikawa, S.; Miyazawa, T. Occurrence of orally administered mulberry 1-deoxynojirimycin in rat plasma. J. Agric. Food Chem. 2007, 55 (22), 8928-8933.
14. Tsuruoka, T.; Fukuyasu, H.; Ishii, M.; Usui, T.; Shibahara, S.; Inouye, S. Inhibition of mouse tumor metastasis with nojirimycinrelated compounds. J. Antibiot. (Tokyo) 1996, 49 (2), 155-161.
15. Spearman, M. A.; Damen, J. E.; Kolodka, T.; Greenberg, A. H.; Jamieson, J. C.; Wright, J. A. Differential effects of glycoprotein processing inhibition on experimental metastasis formation by T24-H-ras transformed fibroblasts. Cancer Lett. 1991, 57 (1), 7-13.
16. Seftor,R. E.; Seftor, E.A.;Grimes,W. J.; Liotta, L.A.; Stetler-Stevenson, W. G.; Welch, D. R.; Hendrix,M. J. Human melanoma cell invasion is inhibited in vitro by swainsonine and deoxymannojirimycin with a concomitant decrease in collagenase IV expression. Melanoma Res. 1991, 1 (1), 43-54.
17. Atsumi, S.; Nosaka, C.; Ochi, Y.; Iinuma, H.; Umezawa, K. Inhibition of experimental metastasis by an R-glucosidase inhibitor, 1,6-epi-cyclophellitol. Cancer Res. 1993, 53 (20), 4896-4899.
18. Goss, P. E.; Reid, C. L.; Bailey, D.; Dennis, J. W. Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies. Clin. Cancer Res. 1997, 3 (7), 1077-1086.
19. Guerrera, M.; Ladisch, S. N-butyldeoxynojirimycin inhibits murine melanoma cell ganglioside metabolism and delays tumor onset. Cancer Lett. 2003, 201 (1), 31-40.
20. Mellor, H. R.; Neville, D. C.; Harvey, D. J.; Platt, F. M.; Dwek, R. A.; Butters, T. D. Cellular effects of deoxynojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem. J. 2004, 381 (Pt 3), 867-875.
21. Clark, I. M.; Swingler, T. E.; Sampieri, C. L.; Edwards, D. R. The regulation of matrix metalloproteinases and their inhibitors. Int. J. Biochem. Cell Biol. 2008, 40 (6-7), 1362-1378.
22. Sampieri, C. L.; Nuttall, R. K.; Young, D. A.; Goldspink, D.; Clark, I. M.; Edwards, D. R. Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes. Matrix Biol. 2008, 27 (2), 128-138.
23. Khokha, R.; Waterhouse, P.; Yagel, S.; Lala, P. K.; Overall, C. M.; Norton, G.; DenhardtD. T. Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells. Science 1989, 243 (4893), 947-950.
24. Ray, S.; Chattopadhyay, N.; Biswas, N.; Chatterjee, A. Regulatory molecules in tumor metastasis. J. Environ. Pathol. Toxicol. Oncol. 1999, 18 (4), 251-259.
25. Khokha, R. Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. J. Natl. Cancer. Inst. 1994, 86 (4), 299-304.
26. Olden, K.; Mohla, S.; Newton, S. A.; White, S. L.; Humphries, M. J. Use of antiadhesive peptide and swainsonine to inhibit metastasis. Ann. N.Y. Acad. Sci. 1988, 551, 421-441 (discussion 441-422).
27. Reddy, B. V.; Kalraiya, R. D. Sialilated β-1,6 branched N-ligosaccharides modulate adhesion, chemotaxis and motility of melanoma cells: effect on invasion and spontaneous metastasis properties. Biochim. Biophys. Acta 2006, 1760 (9), 1393-1402.
28. Elbein, A. D. Glycosidase inhibitors: inhibitors of N-linked oligosaccharide processing. FASEB J. 1991, 5 (15), 3055-3063.
29. Zhou, Y.; Zhao, Y.; O'Boyle, K. M.; Murphy, P. V. Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3- triazoles. Bioorg. Med. Chem. Lett. 2008, 18 (3), 954-958.