Characterizing human cancer metabolomics with ex vivo1H HRMAS MRS

Technology in Cancer Research and Treatment

Volumn 9, Issue 4, 2010, Pages 381-391

  DeFeo, Elita M ^a   Cheng, Leo L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Brain; Breast; Cancer; Cervical; Clinical application; Colorectal; Diagnosis; Lung; Magic angle spinning; Magnetic resonance spectroscopy; Metabolomics; Prostate

Indexed keywords

TUMOR MARKER;

HUMAN; METABOLISM; METABOLOMICS; NEOPLASMS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS; NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77956524969     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.1177/153303461000900407     Document Type: Review

References (47)

1. Fass, L. Imaging and cancer: a review. Mol Oncol 2, 115-152 (2008).
2. Wang, X. Z., Wang, B., Gao, Z. Q., Liu, J. G., Liu, Z. Q., Niu, Q. L., Sun, Z. K., Yuan, Y. X. 1H-MRSI of prostate cancer: The relationship between metabolite ratio and tumor proliferation. Eur J Radiol, In Press (2008).
3. Mazaheri, Y., Hricak, H., Fine, S. W., Akin, O., Shukla-Dave, A., Ishill, N. M., Moskowitz, C. S., Grater, J. E., Reuter, V. E., Zakian, K. L., Touijer, K. A., Koutcher, J. A. Prostate tumor volume measurement with combined T2-weighted imaging and diffusion-weighted MR: correlation with pathologic tumor volume. Radiology 252, 449-457 (2009).
4. Xu, J., Humphrey, P. A., Kibel, A. S., Snyder, A. Z., Narra, V. R., Ackerman, J. J., Song, S. K. Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans. Magn Reson Med 61, 842-850 (2009).
5. Kim, J. K., Jang, Y. J., Cho, G. Multidisciplinary functional MR imaging for prostate cancer. Korean J Radiol 10, 535-551 (2009).
6. Puech, P., Potiron, E., Lemaitre, L., Leroy, X., Haber, G. P., Crouzet, S., Kamoi, K., Villers, A. Dynamic contrast-enhanced-magnetic resonance imaging evaluation of intraprostatic prostate cancer: correlation with radical prostatectomy specimens. Urology 74, 1094-1099 (2009).
7. Spratlin, J. L., Serkova, N. J., Eckhardt, S. G. Clinical applications of metabolomics in oncology: a review. Clin Cancer Res 15, 431-440 (2009).
8. Cheng, L. L., Lean, C. L., Bogdanova, A., Wright, S. C., Jr., Ackerman, J. L., Brady, T. J., Garrido, L. Enhanced resolution of proton NMR spectra of malignant lymph nodes using magic-angle spinning. Magn Reson Med 36, 653-658 (1996).
9. Cheng, L. L., Ma, M. J., Becerra, L., Ptak, T., Tracey, I., Lackner, A., Gonzalez, R. G. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 94, 6408-6413 (1997). (Pubitemid 27270698)
10. Lentz, M. R., Taylor, J. L., Feldman, D. A., Cheng, L. L. Current clinical applications of in vivo magnetic resonance spectroscopy and spectroscopic imaging. Current Medical Imaging Reviews 1, 271-302 (2005).
11. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Thun, M. J. Cancer statistics, 2009. CA Cancer J Clin 59, 225-249 (2009).
12. Rocha, C. M., Barros, A. S., Gil, A. M., Goodfellow, B. J., Humpfer, E., Spraul, M., Carreira, I. M., Melo, J. B., Bernardo, J., Gomes, A., Sousa, V., Carvalho, L., Duarte, I. F. Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy. J Proteome Res 9, 319-332 (2010).
13. Jordan, K. W., Adkins, C. B., Su, L., Halpern, E. F., Mark, E. J., Christiani, D. C., Cheng, L. L. Comparison of squamous cell carcinoma and adenocarcinoma of the lung by metabolomic analysis of tissue-serum pairs. Lung Cancer, In Press (2009).
14. Lehman, C. D., Smith, R. A. The role of MRI in breast cancer screening. J Natl Compr Canc Netw 7, 1109-1115 (2009).
15. Partridge, A. H., Winer, E. P. On mammography-more agreement than disagreement. N Engl J Med 361, 2499-2501 (2009).
16. Sitter, B., Lundgren, S., Bathen, T. F., Halgunset, J., Fjosne, H. E., Gribbestad, I. S. Comparison of HR MAS MR spectroscopic profiles of breast cancer tissue with clinical parameters. NMR Biomed 19, 30-40 (2006). (Pubitemid 43250787)
17. Giskeodegard, G. F., Grinde, M. T., Sitter, B., Axelson, D. E., Lundgren, S., Fjosne, H. E., Dahl, S., Gribbestad, I. S., Bathen, T. F. Multivariate modeling and prediction of breast cancer prognostic factors using MR metabolomics. J Proteome Res, In Press (2010).
18. rd., Buys, S. S., Chia, D., Church, T. R., Fouad, M. N., Gelmann, E. P., Kvale, P. A., Reding, D. J., Weissfeld, J. L., Yokochi, L. A., O'Brien, B., Clapp, J. D., Rathmell, J. M., Riley, T. L., Hayes, R. B., Kramer, B. S., Izmirlian, G., Miller, A. B., Pinsky, P. F., Prorok, P. C., Gohagan, J. K., Berg, C. D. Mortality results from a randomized prostate-cancer screening trial. N Engl J Med 360, 1310-1319 (2009).
19. Schroder, F. H., Hugosson, J., Roobol, M. J., Tammela, T. L., Ciatto, S., Nelen, V., Kwiatkowski, M., Lujan, M., Lilja, H., Zappa, M., Denis, L. J., Recker, F., Berenguer, A., Maattanen, L., Bangma, C. H., Aus, G., Villers, A., Rebillard, X., van der Kwast, T., Blijenberg, B. G., Moss, S. M., de Koning, H. J., Auvinen, A. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med 360, 1320-1328 (2009).
20. Tessem, M. B., Swanson, M. G., Keshari, K. R., Albers, M. J., Joun, D., Tabatabai, Z. L., Simko, J. P., Shinohara, K., Nelson, S. J., Vigneron, D. B., Gribbestad, I. S., Kurhanewicz, J. Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Magn Reson Med 60, 510-516 (2008).
21. Swanson, M. G., Keshari, K. R., Tabatabai, Z. L., Simko, J. P., Shinohara, K., Carroll, P. R., Zektzer, A. S., Kurhanewicz, J. Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy. Magn Reson Med 60, 33-40 (2008). (Pubitemid 351956607)
22. Swanson, M. G., Zektzer, A. S., Tabatabai, Z. L., Simko, J., Jarso, S., Keshari, K. R., Schmitt, L., Carroll, P. R., Shinohara, K., Vigneron, D. B., Kurhanewicz, J. Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy. Magn Reson Med 55, 1257-1264 (2006). (Pubitemid 43856762)
23. van Asten, J. J., Cuijpers, V., Hulsbergen-van de Kaa, C., Soede-Huijbregts, C., Witjes, J. A., Verhofstad, A., Heerschap, A. High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies. Magma 21, 435-442 (2008).
24. Cheng, L. L., Burns, M. A., Taylor, J. L., He, W., Halpern, E. F., McDougal, W. S., Wu, C. L. Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy. Cancer Res 65, 3030-3034 (2005). (Pubitemid 40524579)
25. Ryan, C. J., Small, E. J. Prostate cancer update: 2005. Curr Opin Oncol 18, 284-288 (2006).
26. Hricak, H., Choyke, P. L., Eberhardt, S. C., Leibel, S. A., Scardino, P. T. Imaging prostate cancer: a multidisciplinary perspective. Radiology 243, 28-53 (2007). (Pubitemid 46579693)
27. Stenman, K., Hauksson, J. B., Grobner, G., Stattin, P., Bergh, A., Riklund, K. Detection of polyunsaturated omega-6 fatty acid in human malignant prostate tissue by 1D and 2D high-resolution magic angle spinning NMR spectroscopy. Magma 22, 327-331 (2009).
28. Jordan, K. W., He, W., Halpern, E. F., Wu, C. L., Cheng, L. L. Evaluation of tissue metabolites with high resolution magic angle spinning MR spectroscopy human prostate samples after three-year storage at -80 degrees C. Biomark Insights 2, 147-154 (2007).
29. Burns, M. A., Taylor, J. L., Wu, C. L., Zepeda, A. G., Bielecki, A., Cory, D., Cheng, L. L. Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning. Magn Reson Med 54, 34-42 (2005). (Pubitemid 40898394)
30. Maxeiner, A., Adkins, C. B., Zhang, Y., Taupitz, M., Halpern, E. F., McDougal, W. S., Wu, C. L., Cheng, L. L. Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles. Prostate, In Press (2009).
31. Davies, N. P., Wilson, M., Natarajan, K., Sun, Y., Macpherson, L., Brundler, M. A., Arvanitis, T. N., Grundy, R. G., Peet, A. C. Non-invasive detection of glycine as a biomarker of malignancy in childhood brain tumours using in-vivo (1)H MRS at 1.5 Tesla confirmed by ex-vivo high-resolution magic-angle spinning NMR. NMR Biomed, 23, 80-87 (2009).
32. Opstad, K. S., Bell, B. A., Griffiths, J. R., Howe, F. A. Toward accurate quantification of metabolites, lipids, and macromolecules in HRMAS spectra of human brain tumor biopsies using LCModel. Magn Reson Med 60, 1237-1242 (2008).
33. Andronesi, O. C., Blekas, K. D., Mintzopoulos, D., Astrakas, L., Black, P. M., Tzika, A. A. Molecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers. Int J Oncol 33, 1017-1025 (2008).
34. Wilson, M., Davies, N. P., Grundy, R. G., Peet, A. C. A quantitative comparison of metabolite signals as detected by in vivo MRS with ex vivo 1H HR-MAS for childhood brain tumours. NMR Biomed 22, 213-219 (2009).
35. Martinez-Bisbal, M. C., Monleon, D., Assemat, O., Piotto, M., Piquer, J., Llacer, J. L., Celda, B. Determination of metabolite concentrations in human brain tumour biopsy samples using HR-MAS and ERETIC measurements. NMR Biomed 22, 199-206 (2009).
36. Wilson, M., Davies, N. P., Brundler, M. A., McConville, C., Grundy, R. G., Peet, A. C. High resolution magic angle spinning 1H NMR of childhood brain and nervous system tumours. Mol Cancer 8, 6 (2009).
37. Righi, V., Andronesi, O. C., Mintzopoulos, D., Black, P. M., Tzika, A. A. High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors. Int J Oncol 36, 301-306 (2010).
38. Erb, G., Elbayed, K., Piotto, M., Raya, J., Neuville, A., Mohr, M., Maitrot, D., Kehrli, P., Namer, I. J. Toward improved grading of malignancy in oligodendrogliomas using metabolomics. Magn Reson Med 59, 959-965 (2008). (Pubitemid 351590507)
39. Monleon, D., Morales, J. M., Gonzalez-Darder, J., Talamantes, F., Cortes, O., Gil-Benso, R., Lopez-Gines, C., Cerda-Nicolas, M., Celda, B. Benign and atypical meningioma metabolic signatures by high-resolution magic-angle spinning molecular profiling. J Proteome Res 7, 2882-2888 (2008).
40. Righi, V., Roda, J. M., Paz, J., Mucci, A., Tugnoli, V., Rodriguez-Tarduchy, G., Barrios, L., Schenetti, L., Cerdan, S., Garcia-Martin, M. L. 1H HR-MAS and genomic analysis of human tumor biopsies discriminate between high and low grade astrocytomas. NMR Biomed 22, 629-637 (2009).
41. Tzika, A. A., Astrakas, L., Cao, H., Mintzopoulos, D., Andronesi, O. C., Mindrinos, M., Zhang, J., Rahme, L. G., Blekas, K. D., Likas, A. C., Galatsanos, N. P., Carroll, R. S., Black, P. M. Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies. Int J Mol Med 20, 199-208 (2007).
42. Cheng, L. L., Anthony, D. C., Comite, A. R., Black, P. M., Tzika, A. A., Gonzalez, R. G. Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy. Neuro Oncol 2, 87-95 (2000).
43. Chan, E. C., Koh, P. K., Mal, M., Cheah, P. Y., Eu, K. W., Backshall, A., Cavill, R., Nicholson, J. K., Keun, H. C. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). J Proteome Res 8, 352-361 (2009).
44. Righi, V., Durante, C., Cocchi, M., Calabrese, C., Di Febo, G., Lecce, F., Pisi, A., Tugnoli, V., Mucci, A., Schenetti, L. Discrimination of healthy and neoplastic human colon tissues by ex vivo HR-MAS NMR spectroscopy and chemometric analyses. J Proteome Res 8, 1859-1869 (2009).
45. Jordan, K. W., Nordenstam, J., Lauwers, G. Y., Rothenberger, D. A., Alavi, K., Garwood, M., Cheng, L. L. Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum 52, 520-525 (2009).
46. De Silva, S. S., Payne, G. S., Thomas, V., Carter, P. G., Ind, T. E., deSouza, N. M. Investigation of metabolite changes in the transition from pre-invasive to invasive cervical cancer measured using (1)H and (31)P magic angle spinning MRS of intact tissue. NMR Biomed 22, 191-198 (2009).
47. Wu, C. L., Jordan, K. W., Ratai, E. M., Sheng, J., Adkins, C. B., DeFeo, E. M., Jenkins, B. G., Ying, L., McDougal, W. S., Cheng, L. L. Metabolomic imaging for human prostate cancer detection. Science Translational Medicine 2, 1-7 (2010).