Clinical use of polihexanide on acute and chronic wounds for antisepsis and decontamination

Skin Pharmacology and Physiology

Volumn 23, Issue SUPPL. 1, 2010, Pages 45-51

  Eberlein, T ^a   Assadian, O ^b  

^a Dermatologist/Allergologist   (Spain)

^b UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Acute wounds; Antisepsis; Chronic wounds; Decontamination; Polihexanide; Wound cleansing

Indexed keywords

CHLORHEXIDINE GLUCONATE; LAVANID; LAVASEPT; LAVASORB; OCTENIDINE; POLY(HEXAMETHYLENEBIGUANIDE); POVIDONE IODINE; PRONTOSAN; SERASEPT; SILVER NITRATE; SILVER PROTEIN; SULFADIAZINE SILVER; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTISEPSIS; BIOCOMPATIBILITY; CHRONIC WOUND; CLINICAL RESEARCH; DRUG CONTRAINDICATION; DRUG INDICATION; HUMAN; INFECTION PREVENTION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; SKIN DECONTAMINATION; WOUND CARE; WOUND INFECTION;

ANTI-INFECTIVE AGENTS, LOCAL; ANTISEPSIS; BIGUANIDES; DEBRIDEMENT; DECONTAMINATION; HUMANS; THERAPEUTIC IRRIGATION; TIME FACTORS; TREATMENT OUTCOME; WOUND HEALING;

EID: 77956507010     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000318267     Document Type: Review

References (53)

1. Pringle J: Observations on the Diseases of the Army, ed 4 revised. London, Millar, Wilson, Durham, Payne, 1764.
2. Lister J: Amputation, anaesthetics; in Holmes T (ed): A System of Surgery, Theoretical and Practical. London, Robson, Levey, and Franklin, 1860, vol 3: Operative Surgery.
3. Lister J: On the antiseptic principle on the practice of surgery. Lancet 1867;90:353-356.
4. Kocher T: Die antiseptische Wundbehand-lung mit schwachen Chlorzinklosungen in der Berner Klinik; in Volksmanjn R (ed): Sammlung klinischer Vortrage. Leipzig, Breitkopf und Hartel, 1881.
5. Carrel A, Lecomte Du Noiiy P, Carrel A: Cicatrization of wounds. 9. Influence on the healing of wounds of variations in the osmotic tension of the dressing. J Exp Med 1917;26:279-295.
6. Lister J: An address on the present position of antiseptic surgery. BMJ 1890; 1546:377-379.
7. Gillespie WA: Chemical disinfection in the prevention of infection in hospital. J Clin Pathol 1961;14:26-31.
8. Willenegger H, Roth B, Ochsner P: The return of local antiseptics in surgery. Injury 1995;26:28-33.
9. Davies A, Field BS: Action of biguanides, phenols and detergents on Escherichia coli and its spheroplasts. J Appl Bact 1969;23: 233-243.
10. Ikeda T, Tazuke S, Watanabe M: Interaction of biologically active molecules with phospholipid membranes. Fluorescence depolar-isation studies on the effect of polymeric bio-cide bearing biguanides in the main chain. Biochim Biophys Acta 1983;735:380-386.
11. Werner HP: Microbicidal effectiveness of selected antiseptics. HygMed 1992;17:51-59.
12. Kramer A, Adrian V, Werner HP: Mikrobi-zidie und Gewebevertraglichkeit des Antiin-fektivums Lavasept® mit Schlussfolgerun-gen fur die Indikationbreite; in Ganzer D, Kramer A, Mayer G (eds): Prophylaxe und Therapie von Infektionen in der Orthopadie. Wiesbaden, mhp, 1997, pp 11-26.
13. Schmit-Neuerburg K, Bettag C, Schlickewei W, Fabry W, Hanke J, Renzig-Kohler K, Hirche H, Kock HJ: Wirksamkeit eines neuartigen Antisepticum in der Behandlung kontaminierter Weichteilwunden. Chirurg 2001;72:61-71.
14. Fabry W, Trampenau C, Bettag C, Hand-schin AE, Lettgen B, Huber FX, Hillmeier J, Kock AJ: Bacteria decontamination of surgical wounds with Lavasept®. Int J Hyg Environ Health 2006;209:567-573.
15. Roth B, Assadian O, Wurmitzer F, Kramer A: Surgical site infections after primary antiseptic cleansing of dirty-contaminated wounds by polihexanide, PVP iodine resp. hydrogen peroxide. GMS Krankenhaushyg Interdiszip2007;2: Doc58(20071228).
16. Muller G, Kramer A: Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother 2008;61: 1281-1287.
17. Disch AC, Matziolis G, Perka C: Two-stage operative strategy without local antibiotic treatment for infected hip arthroplasty: clinical and radiological outcome. Arch Orthop Trauma Surg 2007;127:691-697.
18. Schmidtchen A, Davoudi M, Andersson E: Potent antibacterial effects of polyhexa-methylene biguanide on common chronic ulcer-derived bacteria. Annu Conf EWMA, Pisa, 2003.
19. Kramer A, Roth B: Polihexanid; in Kramer A, Assadian O (eds): Wallhaussers Praxis der Sterilisation, Desinfektion, Antiseptik und Konservierung. Stuttgart, Thieme, 2008, pp 789-793.
20. Rosin M, Welk A, Kocher T, Majic-Todt A, Kramer A, Pitten FA: The effect of a poly-hexamethylene biguanide mouthrinse compared to an essential oil rinse and a chlorhex-idine rinse on bacterial counts and 4-day plaque regrowth. J Clin Periodontol 2002;29: 392-399.
21. Wiegand C, Abel M, Kramer A, Muller G, Ruth P, Hipler UC: Viability and proliferation of fibroblasts, keratinocytes and HaCaT-cells influenced by polihexanide. EWMAJ;7:109.
22. Wiegand C, Abel M, Ruth P, Hipler U: Protective effect of polihexanide on HaCaT keratinocytes in co-culture with Staphylococcus aureus. EWMA J 2008;8:178.
23. Kramer A, Roth B, Muller G, Rudolph P, Klocker N: Influence of the antiseptic agents polihexanide and octenidine on FL-cells and on healing of experimental superficial aseptic wounds in piglets. A double-blind, randomised, stratified, controlled, parallel-group study. Skin Pharmacol Physiol 2004; 17:141-146.
24. Daeschlein G, Assadian O, Bruck JC, Meinl C, Kramer A, Koch S: Feasibility and clinical applicability of polihexanide for treatment of second-degree burn wounds. Skin Pharmacol Physiol 2007;20:292-296.
25. Bolton L, Oleniacz W, Constantine B, Kelli-her BO, Jensen D, Means B, Rovee D: Repair and antibacterial effects of topical antiseptic agents in vivo; in Maibach HI, Lowe N J (eds): Models in Dermatology. Basel, Karger, 1985, pp 145-158.
26. Kallenberger A, Kallenberger C, Willeneg-ger H: Experimentelle Untersuchungen zur Gewebevertraglichkeit von Antiseptika. HygMed 1991;16:383-395.
27. Andriessen A, Eberlein T: Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds 2008;20:171-175.
28. Ikeda T, Tazuke S, Watanabe M: Interaction of biologically active molecules with phospholipid membranes. 1. Fluorescence depolarization studies on the effect of polymeric biocide bearing biguanide groups in the main chain. Biochim Biophys Acta 1983;735: 380-386.
29. Muller G, Kramer A: Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother 2008;61: 1281-1287.
30. Assadian O, Kramer A: Antisepsis; in Kramer A, Assadian O (eds): Wallhaussers Praxis der Sterilisation, Desinfektion, Antisep-tik und Konservierung. Stuttgart, Thieme, 2008.
31. Gilbert P, Moore LE: Cationic antiseptics: diversity of action under a common epithet. J Appl Microbiol 2005;99:703-715.
32. Pietsch M, Kraft B: Antimikrobielle Wirksamkeit ausgewahlter Substanzen fiir die Wasserdesinfektion in Dentaleinheiten mit Biofilm. Aseptica 2006;12:3.
33. Harbs N, Siebert J: In vitro efficacy of octenidine and polihexanide against biofilms composed of Pseudomonas aeruginosa. GMS Krankenhaushyg Interdiszip 2007; 2:Doc45(20071228).
34. Seipp HM, Hofmann S, Hack A, Skowronsky A, Hauri A: Wirksamkeit verschiedener Wundspullosungen gegemiber Biofilmen. ZfW 2005;10:160-164.
35. Daeschlein G, Assadian O, Bruck JC, Meinl C, Kramer A, Koch S: Feasibility and clinical applicability of polihexanide for treatment of second-degree burn wounds. Skin Pharmacol Physiol 2007;20:292-296.
36. Korber A, Seipp H-M, Hofmann S: Efficacy of different wound dressings on artificial plaques of fibrin. EWMA J 2008;8:261.
37. Kaehn K, Eberlein T: Polyhexanide (PHMB) and betaine in wound care management. EWMA J 2008;8:13-17.
38. Mulder GD, Cavorsi JP, Lee DK: Feature: Polyhexamethylene biguanide (PHMB): an addendum to current topical antimicrobials. Wounds 2007;19:173-182.
39. Bruckner M, Schwarz C, Otto F, Heillinger J, Wild T: Evaluation of cellulose and polyhexamethylene biguanide (Suprasorb® X+PHMB) in therapy of infected wounds. EWMAJ2008;8:54.
40. Mosti G, Mattaliano V: First Italian experience with a hydrobalanced cellulose-based wound dressing on hospital-patients with critically-colonized or locally infected chronic wounds. Poster. EWMA J 2008;8: 168.
41. Mosti G, Mattaliano V: Successful therapy of critically-colonised or locally infected wounds with a new hydrobalanced cellulose-based wound dressing with polihexanide on out-patients. EWMA J 2008;8:169.
42. Wiegand C, Abel M, Ruth P, Hipler UC: Polihexanide inhibits the formation of ROS/RNS in vitro. EWMA J 2008;8:178.
43. Schnuch A, Geier J, Uter W, Basketter DA, Jowsey IR: The biocide polyhexamethylene biguanide remains an uncommon contact allergen. Contact Dermatitis 2007;56:235-239.
44. Schnuch A, Geier J, Brasch J, Fuchs T, Pirker C, Schulze-Dirks A, Basketter DA: Polyhexa-methylenebiguanide: a relevant contact allergen? Contact Dermatitis 2000;42:302-303.
45. Freise J, Kohaus S, Korber A, Hillen U, Kroger K, Grabbe S, Dissemond J: Contact sensitization in patients with chronic wounds: results of a prospective investigation. J Eur Acad Dermatol Venereol 2008;22: 1203-1207.
46. Krautheim AB, Jermann TH, Bircher AJ: Chlorhexidine anaphylaxis: case report and review of the literature. Contact Dermatitis 2004;50:113-116.
47. Deutscher Arzneimittel-Codex DAC/Neues Rezeptur-Formularium NRF. Eschborn, Govi, 2008.
48. Wilhelms T, Schulze D, Alupei IC, Rohrer C, Abel M, Wiegand C, Hipler UC: Release of polyhexamethylene biguanidine hydrochloride (PHMB) from a hydrobalanced cellulose wound dressing with PHMB. EWMA J 2007; 7:113.
49. Werner H, Kramer A: Mikrobiologische An-forderungen an lokale Antiinfektiva unter spezieller Berucksichtigung der antiinfek-tiven Wundbehandlung; in Kramer A, Wendt M, Werner H-P (eds): Moglichkeiten und Perspektiven der klinischen Antiseptik. Wiesbaden, mhp, 1995, pp 26-30.
50. European Wound Management Association (EWMA): Position Document: Identifying Criteria for Wound Infection. London, MEP Ltd, 2005: 1-17.
51. Dissemond J, Gerber V, Kramer A, Riepe G, Strohal R, Vasel-Biergans A, Eberlein T: Practice-oriented expert recommendation for the treatment of critically colonised and locally infected wounds using polihexanide. ZfW 2009;14:20-26.
52. Dissemond J, Gerber V, Kramer A, Riepe G, Strohal R, Vasel-Biergans A, Eberlein T: A practice-orientated recommendation for treatment of critically colonized and locally infected wounds using polihexanide. J Wound Tech 2010;7:27-33.
53. Kammerlander G, Andriessen A, Asmussen P D, Brunner U, Eberlein T: Role of the wet-to-dry phase of cleansing in preparing the chronic wound bed for dressing application. J Wound Care 2005;14:349-352.