Protective effect of edaravone against renal ischemia/reperfusion injury and compared with ischemic postconditioning in rats

Yaoxue Xuebao

Volumn 45, Issue 7, 2010, Pages 840-848

  Li, Yan ^a   Xia, An Zhou ^a   Xing, Shu Hua ^a  

^a XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Edaravone postconditioning; Ischemic postconditioning; Renal ischemia reperfusion injury

Indexed keywords

NORPHENAZONE; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; ISCHEMIC POSTCONDITIONING; KIDNEY FUNCTION; KIDNEY ISCHEMIA; MALE; NICK END LABELING; NONHUMAN; RAT; RENAL PROTECTION; REPERFUSION INJURY; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIPYRINE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOOD UREA NITROGEN; CREATININE; FREE RADICAL SCAVENGERS; ISCHEMIC POSTCONDITIONING; KIDNEY; MALE; MALONDIALDEHYDE; PROTO-ONCOGENE PROTEINS C-BCL-2; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 77956463808     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Martins PN, Chandraker A, Tullius SG. Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment [J]. Transpl Int, 2006, 19: 351-359.
2. Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning [J]. Am J Physiol Heart Circ Physiol, 2003, 285: H579-H588.
3. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischemia-reperfusion injury: targeting the reperfusion injury salvage kinase (RISK)-pathway [J]. Cardiovasc Res, 2004, 61: 448-460.
4. Masaki Y, Kumano K, He N, et al. Protective effects of MCI-186 on cold kidney preservation/reperfusion injury in the rat [J]. Transplant Proc, 1996, 28: 1885-1886.
5. Yin T, Sandhu G, Wolfgang CD, et al. Tissue-specific pattern of stress kinase activation in ischemic/reperfused heart and kidney [J]. J Biol Chem, 1997, 272: 19943-19950.
6. Di Mari JF, Davis R, Safirstein RL. MAPK activation determines renal epithelial cell survival during oxidative injury [J]. Am J Physiol, 1999, 277: F195-F203.
7. Nakamoto N, Tada S, Kameyama K, et al. A free radical scavenger, edaravone, attenuates steatosis and cell death via reducing inflammatory cytokine production in rat acute liver injury [J]. Free Radic Res, 2003, 37: 849-859.
8. Zhang W, Sato K, Hayashi T, et al. Extension of ischemic therapeutic time window by a free radical scavenger, edaravone, reperfused with tPA in rat brain [J]. Neurol Res, 2004, 26: 342-348.
9. Yagi K, Kitazato KT, Uno M, et al. Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator [J]. Stroke, 2009, 40: 626-631.
10. Song Y, Gong YY, Xie ZG, et al. Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats [J]. Acta Pharmacol Sin, 2008, 29: 823-828.
11. Jablonski P, Howden BO, Rae DA, et al. An experimental model for assessment of renal recovery from warm ischemia [J]. Transplantation, 1983, 35: 198-204.
12. Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with Folin Phenol reagent [J]. J Biol Chem, 1951, 193: 265-275.
13. Szwarc I, Soullier S, Gayrard N, et al. Ischemic postconditioning prevents ischemic acute renal failure [J]. Transplant Proc, 2007, 39: 2554-2556.
14. Liu XH, Chen H, Zhan BY, et al. Attenuation of reperfusion injury by renal ischemic postconditioning: the role of NO [J]. Biochem Biophys Res Commun, 2007, 359: 628-634.
15. Chen H, Xing BZ, Liu XH, et al. Ischemic postconditioning inhibits apoptosis after renal ischemia/reperfusion injury in rat [J]. Transpl Int, 2008, 21: 364-371. (Pubitemid 351348006)
16. Paller MS, Hoidal JR, Ferris TF. Oxygen free radicals in ischemic acute renal failure in the rat [J]. J Clin Invest, 1984, 74: 1156-1164.
17. Sueishi K, Mishima K, Makino K, et al. Protection by a radical scavenger edaravone against cisplatin-induced nephrotoxicity in rats [J]. Eur J Pharmacol, 2002, 451: 203-208.
18. Doi K, Suzuki Y, Nakao A, et al. Radical scavenger edaravone developed for clinical use ameliorates ischemia/reperfusion injury in rat kidney [J]. Kidney Int, 2004, 65: 1714-1723.
19. Yoshioka T, Bills T, Moore-Jarrett T, et al. Role of intrinsic antioxidant enzymes in renal oxidant injury [J]. Kidney Int, 1990, 38: 282-288.
20. Kawamura T, Yoshioka T, Bills T, et al. Glucocorticoid activates glomerular antioxidant enzymes and protects glomeruli from oxidant injuries [J]. Kidney Int, 1991, 40: 291-301.
21. Thompson CB. Apoptosis in the pathogenesis and treatment of disease [J]. Science, 1995, 267: 1456-1462.
22. Xu HB, Li L, Liu GQ. Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by guggulsterone [J]. Acta Pharm Sin, 2008, 43: 1190-1197.
23. Green DR. Apoptotic pathways: the roads to ruin [J]. Cell, 1998, 94: 695-698.
24. Gross A, McDonnell JM, Korsmeyer SJ. Bcl-2 family members and the mitochondria in apoptosis [J]. Genes Dev, 1999, 13: 1899-1911.
25. Amemiya S, Kamiya T, Nito C, et al. Anti-apoptotic and neuroprotective effects of edaravone following transient focal ischemia in rats [J]. Eur J Pharmacol, 2005, 516: 125-130.
26. Dong JJ, Takami Y, Tanaka H, et al. Protective effects of a free radical scavenger, MCI-186, on high-glucose-induced dysfunction of human dermal microvascular endothelial cells [J]. Wound Repair Regen, 2004, 12: 607-612.
27. Degli Esposti M, Dive C. Mitochondrial membrane permeabilisation by Bax/Bak [J]. Biochem Biophys Res Commun, 2003, 304: 455-461.
28. Kuwana T, Newmeyer DD. Bcl-2-family proteins and the role of mitochondria in apoptosis [J]. Curr Opin Cell Biol, 2003, 15: 691-699.
29. Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis [J]. Biochem Biophys Res Commun, 2003, 304: 463-470.