Regulation of podocyte BKCa channels by synaptopodin, Rho, and actin microfilaments

American Journal of Physiology - Renal Physiology

Volumn 299, Issue 3, 2010, Pages

  Kim, Eun Young ^a   Suh, Jae Mi ^a   Chiu, Yu Hsin ^a   Dryer, Stuart E ^a  

^a University of Houston   (United States)

Author keywords

Cytoskeleton; Potassium channels; Renal glomerulus; Slit diaphragm; Traffic

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; KCNMA1 PROTEIN, HUMAN; KCNMA1 PROTEIN, MOUSE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SYNPO PROTEIN, HUMAN; SYNPO PROTEIN, MOUSE;

ACTIN FILAMENT; ANIMAL; ANIMAL MODEL; CELL LINE; CELL MEMBRANE; CHANNEL GATING; CYTOLOGY; HUMAN; MOUSE; PHYSIOLOGY; PODOCYTE;

ACTIN CYTOSKELETON; ACTINS; ANIMALS; CELL LINE; CELL MEMBRANE; HUMANS; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; MICE; MICROFILAMENT PROTEINS; MODELS, ANIMAL; PODOCYTES; RHO GTP-BINDING PROTEINS;

EID: 77956460099     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00206.2010     Document Type: Article

References (38)

1. Aktories K, Wilde C, Vogelsgesang M. Rho-modifying C3-like ADP-ribosyltransferases. Rev Physiol Biochem Pharmacol 152: 1-22, 2004.
2. Asanuma K, Kim K, Oh J, Giardino L, Chabanis S, Faul C, Reiser J, Mundel P. Synaptopodin regulates the actin-bundling activity of alphaactinin in an isoform-specific manner. J Clin Invest 115: 1188-1198, 2005.
3. Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol 8: 485-491, 2006.
4. + current. Am J Physiol Cell Physiol 289: C49-C57, 2005.
5. + channel trafficking in developing parasympathetic neurons. J Neurochem 94: 367-379, 2005.
6. Chiu YH, Alvarez-Baron C, Kim EY, Dryer SE. Dominant-negative regulation of cell surface expression by a pentapeptide motif at the extreme COOH terminus of a Slo1 calcium-activated potassium channel splice variant. Mol Pharmacol 77: 497-507, 2010.
7. Cupples WA, Braam B. Assessment of renal autoregulation. Am J Physiol Renal Physiol 292: F1105-F1123, 2007.
8. Drenckhahn D, Franke RP. Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man. Lab Invest 59: 673-682, 1988. (Pubitemid 19009729)
9. + channel that is inhibited by the cytoskeleton in the smooth muscle cell line DDT1 MF-2. J Physiol 496: 663-676, 1996.
10. 2+ permeability. J Physiol 572: 359-377, 2006.
11. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17: 428-437, 2007.
12. Friedrich C, Endlich N, Kriz W, Endlich K. Podocytes are sensitive to fluid shear stress in vitro. Am J Physiol Renal Physiol 291: F856-F865, 2006.
13. Huber TB, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. J Clin Invest 116: 1337-1345, 2006.
14. Huber TB, Schermer B, Müller RU, Höhne M, Bartram M, Calixto A, Hagmann H, Reinhardt C, Koos F, Kunzelmann K, Shirokova E, Krautwurst D, Harteneck C, Simons M, Pavenstädt H, Kerjaschki D, Thiele C, Walz G, Chalfie M, Benzing T. Podocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci USA 103: 17079-17086, 2006.
15. Kanzaki M, Pessin JE. Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling. J Biol Chem 276: 42436-42444, 2001. (Pubitemid 37371155)
16. Ca trafficking to the surface of cultured podocytes. Mol Pharmacol 75: 466-477, 2009.
17. + channels: different effects in embryonic neurons and podocytes. Am J Physiol Cell Physiol 297: C1379-C1388, 2009.
18. + channel isoform and regulates its expression on the cell surface. Am J Physiol Renal Physiol 295: F235-F246, 2008.
19. Kim EY, Ridgway LD, Zou S, Chiu YH, Dryer SE. Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels. Neuroscience 146: 1652-1661, 2007.
20. + channel isoform. J Neurophysiol 97: 3508-3516, 2007.
21. Kremerskothen J, Plaas C, Kindler S, Frotscher M, Barnekow A. Synaptopodin, a molecule involved in the formation of the dendritic spine apparatus, is a dual actin/alpha-actinin binding protein. J Neurochem 92: 597-606, 2005.
22. Kriz W, Elger M, Mundel P, Lemley KV. Structure-stabilizing forces in the glomerular tuft. J Am Soc Nephrol 5: 1731-1739, 1995.
23. 2+-gated (Slo1) potassium channels. FEBS Lett 581: 1000-1008, 2007.
24. + channel: potential implications for the control of glomerular filtration. J Am Soc Nephrol 15: 2981-2987, 2004.
25. Mundel P, Heid HW, Mundel TM, Krüger M, Reiser J, Kriz W. Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes. J Cell Biol 139: 193-204, 1997.
26. Mundel P, Reiser J, Zúñiga Mejía Borja A, Pavenstädt H, Davidson GR, Kriz W, Zeller R. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236: 248-258, 1997.
27. O'Malley D, Harvey J. MAPK-dependent actin cytoskeletal reorganization underlies BK channel activation by insulin. Eur J Neurosci 25: 673-682, 2007. (Pubitemid 46271171)
28. O'Malley D, Irving AJ, Harvey J. Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels. FASEB J 19: 1917-1919, 2005.
29. Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B. Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. J Biol Chem 277: 30183-30190, 2002.
30. + channels in coronary artery smooth muscle cells. Pflügers Arch 446: 523-528, 2003.
31. Ridgway LD, Kim EY, Dryer SE. MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface. Am J Physiol Cell Physiol 297: C55-C65, 2009.
32. Scita G, Confalonieri S, Lappalainen P, Suetsugu S. IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions. Trends Cell Biol 18: 52-60, 2008.
33. Shi J, Mori E, Mori Y, Mori M, Li J, Ito Y, Inoue R. Multiple regulation by calcium of murine homologues of transient receptor potential proteins TRPC6 and TRPC7 expressed in HEK293 cells. J Physiol 561: 415-432, 2004.
34. Tian L, Chen L, McClafferty H, Sailer CA, Ruth P, Knaus HG, Shipston MJ. A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin. FASEB J 20: 2588-2590, 2006.
35. Tian L, McClafferty H, Chen L, Shipston MJ. Reversible tyrosine protein phosphorylation regulates large conductance voltage- and calcium-activated potassium channels via cortactin. J Biol Chem 283: 3067-3076, 2008.
36. Yanagida-Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P. Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. Am J Pathol 171: 415-427, 2007.
37. Zou S, Jha S, Kim EY, Dryer SE. A novel actin-binding domain on Slo1 calcium-activated potassium channels is necessary for their expression in the plasma membrane. Mol Pharmacol 73: 359-368, 2008.
38. + channels. Mol Pharmacol 73: 369-378, 2008.