Neph1 regulates steady-state surface expression of Slo1 Ca 2+-activated K+ channels: Different effects in embryonic neurons and podocytes

American Journal of Physiology - Cell Physiology

Volumn 297, Issue 6, 2009, Pages

  Kim, Eun Young ^a   Chiu, Yu Hsin ^a   Dryer, Stuart E ^a  

^a University of Houston   (United States)

Author keywords

Parasympathetic neurons; Potassium channels; Renal glomerulus; Slit diaphragm; Traffic

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; MULTIPROTEIN COMPLEX; NEPH1; NEPHRIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ISOPROTEIN; KCNMA1 PROTEIN, MOUSE; KIRREL1 PROTEIN, MOUSE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNIT; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL INTERACTION; CELL LINE; CELL STRAIN HEK293; CELL SURFACE; CILIARY GANGLION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; GENE; INTRACELLULAR SPACE; INVERTEBRATE; NERVE CELL; NERVOUS SYSTEM; NONHUMAN; PARASYMPATHETIC NERVE CELL; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SLO1 GENE; ANIMAL; CELL CULTURE; CELL MEMBRANE; CHICK EMBRYO; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; ELECTRIC CONDUCTIVITY; GENETICS; HOMEOSTASIS; HUMAN; IMMUNOPRECIPITATION; METABOLISM; MOUSE; PARASYMPATHETIC GANGLION; PHYSIOLOGY; PRENATAL DEVELOPMENT; TISSUE DISTRIBUTION;

INVERTEBRATA; VERTEBRATA;

ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CHICK EMBRYO; DRUG INTERACTIONS; ELECTRIC CONDUCTIVITY; GANGLIA, PARASYMPATHETIC; HOMEOSTASIS; HUMANS; IMMUNOPRECIPITATION; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA SUBUNITS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MEMBRANE PROTEINS; MICE; NEURONS; PODOCYTES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROTEIN ISOFORMS; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 73449109561     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00354.2009     Document Type: Article

References (45)

1. Bao S, Cagan R. Preferential adhesion mediated by Hibris and Roughest regulates morphogenesis and patterning in the Drosophila eye. Dev Cell 8: 925-935, 2005.
2. Barletta GM, Kovari IA, Verma RK, Kerjaschki D, Holzman LB. Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers. J Biol Chem 278: 19266-19271, 2003.
3. + channels in parasympathetic neurons. Proc Natl Acad Sci USA 98: 2832-2836, 2001.
4. + channels by target-derived TGF beta in vivo and in vitro. Neuron 21: 1045-1053, 1998.
5. + channel trafficking in developing parasympathetic neurons. J Neurochem 94: 367-379, 2005.
6. Ca channels in developing parasympathetic neurons. J Neurophysiol 93: 1174-1182, 2005.
7. Ca channels in developing parasympathetic neurons: role of ADP-ribosylation factors and related proteins. J Neurophysiol 94: 1597-1605, 2005.
8. Chao DL, Shen K. Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C. elegans. Mol Cell Neurosci 39: 248-257, 2008.
9. Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt M, Gupta A, Ramirez-Solis R, Zambrowicz BP, Powell DR. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol 21: 4829-4836, 2001.
10. + currents in chick ciliary ganglion neurons developing in situ. J Neurosci 14: 3156-3165, 1994.
11. Dourado MM, Dryer SE. Changes in the electrical properties of chick ciliary ganglion neurones during embryonic development. J Physiol 449: 411-428, 1992.
12. + channels in acutely dissociated chick ciliary-ganglion neurones. J Physiol 443: 601-627, 1991.
13. Du W, Bautista JF, Yang H, Diez-Sampedro A, You SA, Wang L, Kotagal P, Luders HO, Shi J, Cui J, Richerson GB, Wang QK. Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder. Nat Genet 37: 733-738, 2005.
14. + (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. J Physiol 552: 483-497, 2003.
15. Garg P, Verma R, Nihalani D, Johnstone DB, Holzman LB. Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization. Mol Cell Biol 27: 8698-8712, 2007.
16. Gerke P, Benzing T, Hohne M, Kispert A, Frotscher M, Walz G, Kretz O. Neuronal expression and interaction with the synaptic protein CASK suggest a role for Neph1 and Neph2 in synaptogenesis. J Comp Neurol 498: 466-475, 2006.
17. 2+ signaling by recruitment and activation of phospholipase C-γ1. J Biol Chem 284: 8951-8962, 2009.
18. + channels. J Pharmacol Exp Ther 327: 657-664, 2008.
19. Jones N, Blasutig IM, Eremina V, Ruston JM, Bladt F, Li H, Huang H, Larose L, Li SS, Takano T, Quaggin SE, Pawson T. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 440: 818-823, 2006.
20. Ca trafficking to the surface of cultured podocytes. Mol Pharmacol 75: 466-477, 2009.
21. + channel isoform and regulates its expression on the cell surface. Am J Physiol Renal Physiol 295: F235-F246, 2008.
22. + channels in the absence of direct actin binding. Mol Pharmacol 72: 622-630, 2007.
23. Kim EY, Ridgway LD, Zou S, Chiu YH, Dryer SE. Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels. Neuroscience 146: 1652-1661, 2007.
24. + channel isoform. J Neurophysiol 97: 3508-3516, 2007.
25. 2+ voltage. Biol Res 39: 385-401, 2006.
26. Ca channels by TGFbeta1: an essential role for PI3 kinase signaling and membrane insertion. J Neurophysiol 88: 954-964, 2002.
27. Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS. Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability. J Clin Invest 112: 209-221, 2003.
28. 2+-gated (Slo1) potassium channels. FEBS Lett 581: 1000-1008, 2007.
29. + channel. J Biol Chem 279: 36746-36752, 2004.
30. + channel: potential implications for the control of glomerular filtration. J Am Soc Nephrol 15: 2981-2987, 2004.
31. Otaki Y, Miyauchi N, Higa M, Takada A, Kuroda T, Gejyo F, Shimizu F, Kawachi H. Dissociation of NEPH1 from nephrin is involved in development of a rat model of focal segmental glomerulosclerosis. Am J Physiol Renal Physiol 295: F1376-F1387, 2008.
32. Ridgway LD, Kim EY, Dryer SE. MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface. Am J Physiol Cell Physiol 297: C55-C65, 2009.
33. 2+-activated potassium (BK) α-subunit but not the BK β1-subunit leads to progressive hearing loss. Proc Natl Acad Sci USA 101: 12922-12927, 2004.
34. Sausbier M, Arntz C, Bucurenciu I, Zhao H, Zhou XB, Sausbier U, Feil S, Kamm S, Essin K, Sailer CA, Abdullah U, Krippeit-Drews P, Feil R, Hofmann F, Knaus HG, Kenyon C, Shipston MJ, Storm JF, Neuhuber W, Korth M, Schubert R, Gollasch M, Ruth P. Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice. Circulation 112: 60-68, 2005.
35. + channel deficiency. Proc Natl Acad Sci USA 101: 9474-9478, 2004.
36. Sellin L, Huber TB, Gerke P, Quack I, Pavenstadt H, Walz G. NEPH1 defines a novel family of podocin interacting proteins. FASEB J 17: 115-117, 2003.
37. Shen K, Bargmann CI. The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans. Cell 112: 619-630, 2003.
38. + channels in developing chicken parasympathetic neurons. Proc Natl Acad Sci USA 94: 5934-5938, 1997.
39. + currents by a target-derived factor in developing parasympathetic neurons. Neuron 17: 115-124, 1996.
40. Tian L, Chen L, McClafferty H, Sailer CA, Ruth P, Knaus HG, Shipston MJ. A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin. FASEB J 20: 2588-2590, 2006.
41. Verma R, Kovari I, Soofi A, Nihalani D, Patrie K, Holzman LB. Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization. J Clin Invest 116: 1346-1359, 2006.
42. 2+ channels: differences between chicken sympathetic and parasympathetic neurons suggest different regulatory mechanisms. Proc Natl Acad Sci USA 91: 2858-2862, 1994.
43. Zhou L, Martinez SJ, Haber M, Jones EV, Bouvier D, Doucet G, Corera AT, Fon EA, Zisch AH, Murai KK. EphA4 signaling regulates phospholipase Cγ1 activation, cofilin membrane association, and dendritic spine morphology. J Neurosci 27: 5127-5138, 2007.
44. Zhu J, Sun N, Aoudjit L, Li H, Kawachi H, Lemay S, Takano T. Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes. Kidney Int 73: 556-566, 2008.
45. Zou S, Jha S, Kim EY, Dryer SE. A novel actin-binding domain on Slo1 calcium-activated potassium channels is necessary for their expression in the plasma membrane. Mol Pharmacol 73: 359-368, 2008.