Expression and clinical significance of multidrug resistance proteins in brain tumors

Journal of Experimental and Clinical Cancer Research

Volumn 29, Issue 1, 2010, Pages

  Guo, Zhenhua ^a   Zhu, Jin ^a   Zhao, Lihua ^a   Luo, Qing ^a   Jin, Xianqing ^a  

^a CHILDREN S HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER SUBFAMILY B; CAVEOLIN 1; DNA TOPOISOMERASE (ATP HYDROLYSING); GLUTATHIONE TRANSFERASE P1; LUNG RESISTANCE PROTEIN; ABCB1 PROTEIN, HUMAN; CAV1 PROTEIN, HUMAN; GLYCOPROTEIN P; GSTP1 PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN; RIBONUCLEOPROTEIN;

ARTICLE; ASTROCYTOMA; BLOOD BRAIN BARRIER; BLOOD VESSEL WALL; BRAIN TISSUE; BRAIN TUMOR; CANCER TISSUE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EPENDYMOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; LASER MICROSCOPY; MALE; MEDULLOBLASTOMA; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR CELL; CANCER STAGING; CHEMISTRY; CHINA; CONFOCAL MICROSCOPY; DRUG RESISTANCE; ENDOTHELIUM CELL; GLIA; PATHOLOGY; PRESCHOOL CHILD;

BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAVEOLIN 1; CHILD; CHILD, PRESCHOOL; CHINA; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, NEOPLASM; ENDOTHELIAL CELLS; FEMALE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MICROSCOPY, CONFOCAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM STAGING; NEUROGLIA; P-GLYCOPROTEIN; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 77956459031     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-29-122     Document Type: Article

References (21)

1. Sun H, Dai H, Shaik N, Elmquist WF: Drug efflux transporters in the CNS. Adv Drug Deliv Rev 2003, 55:83-105.
2. Linnet K, Ejsing TB: A review on the impact of P-glycoprotein on the penetration of drugs into the brain. Focus on psychotropic drugs. Eur Neuropsychopharmacol 2008, 18(3):157-169.
3. Bart J, Groen HJ, Hendrikse NH, van der Graaf WT, Vaalburg W, de Vries EG: The blood-brain barrier and oncology: new insights into function and modulation. Cancer Treat Rev 2000, 26:449-462.
4. Demeule M, Régina A, Jodoin J, Laplante A, Dagenais C, Berthelet F, Moghrabi A, Béliveau R: Drug transport to the brain:Key roles for the efflux pump P-glycoprotein in the blood-brain barrier. Vascular Pharmacology 2002, 38:339-348.
5. Choong E, Dobrinas M, Carrupt PA, Eap CB: The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution. Expert Opin Drug Metab Toxicol 2010, 6(8):953-65.
6. Chen C, Liu X, Smith BJ: Utility of mdr1-gene deficient mice in assessing the impact of P-glycoprotein on the pharmacokinetics and pharmacodynamics in drug discovery and development. Curr Drug Metab 2003, 4:272-291.
7. Sun J, He ZG, Cheng G, Wang SJ, Hao XH, Zou MJ: Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction. Med Sci Monit 2004, 10(1):RA5-14.
8. Demeule M, Labelle M, Régina A, Berthelet F, Béliveau R: Isolation of endothelial cell from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms. Biochem Biophys Res Commun 2001, 281:827-834.
9. Pardridge WM, Golden PL, Kang YS, Bickel U: Brain microvascular and astrocyte localization of P-glycoprotein. J Neurochem 1997, 68:1278-1285.
10. Golden PL, Pardridge WM: P-glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries. Brain Res 1999, 819:143-146.
11. Demeule M, Jodoin J, Gingras D, Béliveau R: P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries. FEBS Lett 2000, 466:219-24.
12. Kleihues P, Cavenee WK: World Health Organization classification of tumours. Pathology and genetics of tumours of the nervous system. Lyon:IARC Press, 3 2000, 107-110.
13. Virgintino D, Robertson D, Errede M, Benagiano V, Girolamo F, Maiorano E, Roncali L, Bertossi M: Expression of P-glycoprotein in human cerebral cortex microvessels. J Histochem Cytochem 2002, 50(12):1671-1676.
14. Ronaldson PT, Bendayan M, Gingras D, Piquette-Miller M, Bendayan R: Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures. J Neurochem 2004, 89:788-800.
15. Smart EJ, Ying YS, Mineo C, Anderson RG: A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci USA 1995, 92:10104-10108.
16. Ahmed SN, Brown DA, London E: On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes:physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes. Biochemistry 1997, 36:10944-10953.
17. Hansen CG, Nichols BJ: Exploring the caves: cavins, caveolins and caveolae. Trends Cell Biol 2010, 20(4):177-86.
18. Stan RV: Structure of caveolae. Biochim Biophys Acta 2005, 1746(3):334-348.
19. Lavie Y, Liscovitch M: Changes in lipid and protein constituents of rafts and caveolae in multidrug resistant cancer cells and their functional consequences. Glycoconj J 2000, 17(3-4):253-259.
20. Barakat S, Turcotte S, Demeule M, Lachambre MP, Régina A, Baggetto LG, Béliveau R: Regulation of brain endothelial cells migration and angiogenesis by P-glycoprotein/caveolin-1 interaction. Biochem Biophys Res Commun 2008, 372(3):440-6.
21. Schlachetzki F, Pardridge WM: P-glycoprotein and caveolin-1a in endothelium and astrocytes of primate brain. Neuroreport 2003, 14(16):2041-2046.