Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3

Brain Research

Volumn 1354, Issue , 2010, Pages 15-22

  Fasler Kan, Elizaveta ^a   Suenderhauf, Claudia ^a   Barteneva, Natasha ^b   Poller, Birk ^c,d   Gygax, Daniel ^a   Huwyler, Jörg ^a,c  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Blood brain barrier; Cytokine; hCMEC D3; Interferon; JAK STAT; Neurovascular disease; Signaling

Indexed keywords

ALPHA INTERFERON; CD31 ANTIGEN; CD34 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; INTERLEUKIN 6; JANUS KINASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT6 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; VON WILLEBRAND FACTOR;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CELL ADHESION; CELL DIFFERENTIATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

BLOOD-BRAIN BARRIER; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; JANUS KINASES; MICROSCOPY, CONFOCAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 77956415160     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.07.077     Document Type: Article

References (45)

1. N.J. Abbott Inflammatory mediators and modulation of blood-brain barrier permeability Cell. Mol. Neurobiol. 20 2000 131 147
2. S. Chakraborty, D.K. Kaushik, M. Gupta, and A. Basu Inflammasome signaling at the heart of central nervous system pathology J. Neurosci. Res. 2010
3. A. Chaudhuri, B. Yang, H.E. Gendelman, Y. Persidsky, and G.D. Kanmogne STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier Blood 111 2008 2062 2072
4. Y.E. Chin, M. Kitagawa, W.C. Su, Z.H. You, Y. Iwamoto, and X.Y. Fu Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1 Science 272 1996 719 722 (80- )
5. A.G. de Boer, and P.J. Gaillard Blood-brain barrier dysfunction and recovery J. Neural. Transm. 113 2006 455 462
6. H.E. de Vries, M.C. Blom-Roosemalen, M. van Oosten, A.G. de Boer, T.J. van Berkel, D.D. Breimer, and J. Kuiper The influence of cytokines on the integrity of the blood-brain barrier in vitro J. Neuroimmunol. 64 1996 37 43
7. B.S. Desai, A.J. Monahan, P.M. Carvey, and B. Hendey Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy Cell Transplant. 16 2007 285 299
8. E. Ersvaer, J. Skavland, E. Ulvestad, B.T. Gjertsen, and ∅. Bruserud Effects of interferon gamma on native human acute myelogenous leukaemia cells Cancer Immunol. Immunother. 56 2007 13 24
9. C. Förster, M. Burek, I.A. Romero, B. Weksler, P. Couraud, and D. Drenckhahn Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier J. Physiol. 586 2008 1937 1949
10. D.A. Frank, S. Mahajan, and J. Ritz Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling Nat. Med. 5 1999 444 447
11. I. Galea, M. Bernardes-Silva, P.A. Forse, N. van Rooijen, R.S. Liblau, and V.H. Perry An antigen-specific pathway for CD8 T cells across the blood-brain barrier J. Exp. Med. 204 2007 2023 2030
12. M.C. Gillies, and T. Su Interferon-alpha 2b enhances barrier function of bovine retinal microvascular endothelium in vitro Microvasc. Res. 49 1995 277 288
13. R. Halaban Growth factors and melanomas Semin. Oncol. 23 1996 673 681
14. B.T. Hawkins, and T.P. Davis The blood-brain barrier/neurovascular unit in health and disease Pharmacol. Rev. 57 2005 173 185
15. M.H. Heim, I.M. Kerr, G.R. Stark, and J.E.J. Darnell Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway Science 267 1995 1347 1349 (80- )
16. M.S. Horwitz, C.F. Evans, F.G. Klier, and M.B. Oldstone Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules Lab. Invest. 79 1999 235 242
17. H.K. Huynh, and K. Dorovini-Zis Effects of interferon-gamma on primary cultures of human brain microvessel endothelial cells Am. J. Pathol. 142 1993 1265 1278
18. R. Kerbel, and J. Folkman Clinical translation of angiogenesis inhibitors Nat. Rev. Cancer. 2 2002 727 739
19. J. Kraus, A.K. Ling, S. Hamm, K. Voigt, P. Oschmann, and B. Engelhardt Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro Ann. Neurol. 56 2004 192 205
20. K. Kurz, Y. Gluhcheva, E. Zvetkova, G. Konwalinka, and D. Fuchs Interferon-gamma-mediated pathways are induced in human CD34(+) haematopoietic stem cells Immunobiology 215 2010 452 457
21. A.T. Linke, and D.K. Male Strain-specific variation in constitutive and inducible expression of MHC class II, class I and ICAM-1 on rat cerebral endothelium Immunology 82 1994 88 94
22. R.B. Maccioni, L.E. Rojo, J.A. Fernández, and R.O. Kuljis The role of neuroimmunomodulation in Alzheimer's disease Ann. N. Y. Acad. Sci. 1153 2009 240 246
23. D. Male, and G. Pryce Kinetics of MHC gene expression and mRNA synthesis in brain endothelium Immunology 63 1988 37 42
24. S. Man, E.E. Ubogu, and R.M. Ransohoff Inflammatory cell migration into the central nervous system: a few new twists on an old tale Brain Pathol. 17 2007 243 250
25. S. Meili-Butz, T. Niermann, E. Fasler-Kan, V. Barbosa, N. Butz, D. John, M. Brink, P.T. Buser, and C.E. Zaugg Dimethyl fumarate, a small molecule drug for psoriasis, inhibits Nuclear Factor-kappaB and reduces myocardial infarct size in rats Eur. J. Pharmacol. 586 2008 251 258
26. T. Nagatsu, and M. Sawada Inflammatory process in Parkinson's disease: role for cytokines Curr. Pharm. Des. 11 2005 999 1016
27. J.S. Pachter, H.E. de Vries, and Z. Fabry The blood-brain barrier and its role in immune privilege in the central nervous system J. Neuropathol. Exp. Neurol. 62 2003 593 604
28. A. Pansky, P. Hildebrand, E. Fasler-Kan, L. Baselgia, S. Ketterer, C. Beglinger, and M.H. Heim Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha Int. J. Cancer 85 2000 720 725
29. Y. Persidsky Model systems for studies of leukocyte migration across the blood-brain barrier J. Neurovirol. 5 1999 579 590
30. S. Pestka, C.D. Krause, and M.R. Walter Interferons, interferon-like cytokines, and their receptors Immunol. Rev. 202 2004 8 32
31. B. Poller, H. Gutmann, S. Krähenbühl, B. Weksler, I. Romero, P. Couraud, G. Tuffin, J. Drewe, and J. Huwyler The human brain endothelial cell line hCMEC/D3 as a human blood-brain barrier model for drug transport studies J. Neurochem. 107 2008 1358 1368
32. B. Poller, J. Drewe, S. Krähenbühl, J. Huwyler, and H. Gutmann Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier Cell. Mol. Neurobiol. 30 2010 63 70
33. B. Popko, J.G. Corbin, K.D. Baerwald, J. Dupree, and A.M. Garcia The effects of interferon-gamma on the central nervous system Mol. Neurobiol. 14 1997 19 35
34. M.P. Pusztaszeri, W. Seelentag, and F.T. Bosman Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues J. Histochem. Cytochem. 54 2006 385 395
35. C. Rampon, N. Weiss, C. Deboux, N. Chaverot, F. Miller, D. Buchet, H. Tricoire-Leignel, S. Cazaubon, and A. Baron-Van Evercooren Molecular mechanism of systemic delivery of neural precursor cells to the brain: assembly of brain endothelial apical cups and control of transmigration by CD44 Stem Cells 26 2008 1673 1682
36. F. Ricci, A. Tedeschi, E. Morra, and M. Montillo Fludarabine in the treatment of chronic lymphocytic leukemia: a review Ther. Clin. Risk Manage. 5 2009 187 207
37. L. Roffi, G.C. Mels, G. Antonelli, G. Bellati, F. Panizzuti, A. Piperno, M. Pozzi, D. Ravizza, and G. Angeli Breakthrough during recombinant interferon alfa therapy in patients with chronic hepatitis C virus infection: prevalence, etiology, and management Hepatology 21 1995 645 649
38. A. Tuttolomondo, D. Di Raimondo, R. di Sciacca, A. Pinto, and G. Licata Inflammatory cytokines in acute ischemic stroke Curr. Pharm. Des. 14 2008 3574 3589
39. G. Vanier, M. Segura, M. Lecours, D. Grenier, and M. Gottschalk Porcine brain microvascular endothelial cell-derived interleukin-8 is first induced and then degraded by Streptococcus suis Microb. Pathog. 46 2009 135 143
40. K. Vass, and H. Lassmann Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system Am. J. Pathol. 137 1990 789 800
41. S. Verma, R. Nakaoke, S. Dohgu, and W.A. Banks Release of cytokines by brain endothelial cells: a polarized response to lipopolysaccharide Brain Behav. Immun. 20 2006 449 455
42. P. Viegas, N. Chaverot, H. Enslen, N. Perrière, P. Couraud, and S. Cazaubon Junctional expression of the prion protein PrPC by brain endothelial cells: a role in trans-endothelial migration of human monocytes J. Cell Sci. 119 2006 4634 4643
43. B.B. Weksler, E.A. Subileau, N. Perriere, P. Charneau, K. Holloway, M. Leveque, H. Tricoire-Leignel, A. Nicotra, and S. Bourdoulous Blood-brain barrier-specific properties of a human adult brain endothelial cell line FASEB J. 19 2005 1872 1874
44. T. Wyss-Coray, and L. Mucke Inflammation in neurodegenerative disease-a double-edged sword Neuron 35 2002 419 432
45. B.V. Zlokovic The blood-brain barrier in health and chronic neurodegenerative disorders Neuron 57 2008 178 201