Resectable esophageal cancer: Surgery as primary therapy is not the answer, but then, what is and why?

Journal of Clinical Oncology

Volumn 28, Issue 15, 2010, Pages

  Ajani, Jaffer A ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC AGENT; ANTINEOPLASTIC AGENT;

CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CANCER THERAPY; ESOPHAGUS CANCER; HEALTH CARE COST; HUMAN; LETTER; MORBIDITY; OVERALL SURVIVAL; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); STATISTICAL SIGNIFICANCE; STOMACH CANCER; ESOPHAGUS TUMOR; MULTIMODALITY CANCER THERAPY; NOTE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; ESOPHAGEAL NEOPLASMS; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 77956413910     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2009.26.7591     Document Type: Letter

References (19)

1. Allum WH, Stenning SP, Bancewicz J, et al: Long-term results of a randomized trial of surgery with or without preoperative chemotherapy in esophageal cancer. J Clin Oncol 27:5062-5067, 2009
2. Rice TW, Rusch VW, Apperson-Hansen C, et al: Worldwide esophageal cancer collaboration. Dis Esophagus 22:1-8, 2009
3. Siewert JR, Sendler A, Stein HJ: Esophageal cancer: Surgical approach, in Markman M (ed): Atlas of Cancer. Philadelphia, PA, Current Medicine Group of Springer Science, 2007, pp 211-220
4. Cunningham D, Allum WH, Stenning SP, et al: Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med 355:11-20, 2006
5. Kelsen DP, Winter KA, Gunderson LL, et al: Long-term results of RTOG trial 8911 (USA Intergroup 113): A random assignment trial comparison of chemotherapy followed by surgery compared with surgery alone for esophageal cancer. J Clin Oncol 25:3719-3725, 2007
6. Kelsen DP, Ginsberg R, Pajak TF, et al: Chemotherapy followed by surgery compared with surgery alone for localized esophageal cancer. N Engl J Med 339:1979-1984, 1998
7. Council MR: Surgical resection with or without preoperative chemotherapy in oesophageal cancer: A randomised controlled trial. Lancet 359:1727-1733, 2002
8. Tepper J, Krasna MJ, Niedzwiecki D, et al: Phase III trial of trimodality therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol 26:1086-1092, 2008
9. Urba SG, Orringer MB, Turrisi A, et al: Randomized trial of preoperative chemoradiation versus surgery alone in patients with locoregional esophageal carcinoma. J Clin Oncol 19:305-313, 2001 (Pubitemid 32112841)
10. Cooper JS, Guo MD, Herskovic A, et al: Chemoradiotherapy of locally advanced esophageal cancer: Long-term follow-up of a prospective randomized trial (RTOG 85-01): Radiation Therapy Oncology Group. JAMA 281:1623-1627, 1999 (Pubitemid 29211772)
11. Suntharalingam M, Moughan J, Coia LR, et al: The national practice for patients receiving radiation therapy for carcinoma of the esophagus: Results of the 1996-1999 Patterns of Care Study. Int J Radiat Oncol Biol Phys 56:981-987, 2003
12. Suntharalingam M, Moughan J, Coia LR, et al: Outcome results of the 1996-1999 patterns of care survey of the national practice for patients receiving radiation therapy for carcinoma of the esophagus. J Clin Oncol 23:2325-2331, 2005
13. Ajani JA, Barthel JS, Bekaii-Saab T, et al: Esophageal cancer. J Natl Compr Canc Netw 6:818-849, 2008
14. Pereira B, Gourgou-Bourgade S, Azria D, et al: Neoadjuvant chemoradiotherapy in esophageal cancer: Is it still the question? J Clin Oncol 26:5133-5134, 2008
15. Bosset JF, Gignoux M, Triboulet JP, et al: Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus. N Engl J Med 337:161-167, 1997 (Pubitemid 27306287)
16. Walsh TN, Noonan N, Hollywood D, et al: A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med 335:462-467, 1996 (Pubitemid 26269945)
17. Chirieac LR, Swisher SG, Ajani JA, et al: Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation. Cancer 103:1347-1355, 2005 (Pubitemid 40410728)
18. Rohatgi PR, Swisher SG, Correa AM, et al: Failure patterns correlate with the proportion of residual carcinoma after preoperative chemoradiotherapy for carcinoma of the esophagus. Cancer 104:1349-1355, 2005 (Pubitemid 41356149)
19. Ajani JA, Winter K, Komaki R, et al: Phase II randomized trial of two nonoperative regimens of induction chemotherapy followed by chemoradiation in patients with localized carcinoma of the esophagus: RTOG 0113. J Clin Oncol 26:4551-4556, 2008