Death induction by CD99 ligation in TEL/AML1-positive acute lymphoblastic leukemia and normal B cell precursors

Journal of Leukocyte Biology

Volumn 88, Issue 2, 2010, Pages 405-412

  Husak, Zvenyslava ^a   Printz, Dieter ^a   Schumich, Angela ^a   Pötschger, Ulrike ^a   Dworzak, Michael N ^a,b  

^a CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

Author keywords

BCP; Cell death; DN16

Indexed keywords

CD99 ANTIGEN; MESSENGER RNA; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1; CD99 PROTEIN, HUMAN; CELL ADHESION MOLECULE; LEUKOCYTE ANTIGEN; ONCOPROTEIN; TEL AML1 FUSION PROTEIN; TEL-AML1 FUSION PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BONE MARROW; CELL AGGREGATION; CELL DEATH; CONTROLLED STUDY; CYTOGENETICS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOPHENOTYPING; KARYOTYPE; LEUKEMIA CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOPOIESIS; MAJOR CLINICAL STUDY; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; APOPTOSIS; B LYMPHOCYTE; CHILD; CYTOLOGY; GENETICS; PATHOLOGY; PHYSIOLOGY;

ANTIGENS, CD; APOPTOSIS; B-LYMPHOCYTES; CELL ADHESION MOLECULES; CELL DEATH; CHILD; CORE BINDING FACTOR ALPHA 2 SUBUNIT; HUMANS; LYMPHOPOIESIS; ONCOGENE PROTEINS, FUSION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RNA, MESSENGER;

EID: 77956410691     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0210097     Document Type: Article

References (45)

1. Levy, R., Dilley, J., Fox, R. I., Warnk, R. (1979) A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies. Proc. Natl. Acad. Sci. USA 76, 6552-6556. (Pubitemid 10163436)
2. Dworzak, M. N., Fritsch, G., Buchinger, P., Fleischer, C., Printz, D., Zellner, A., Schollhammer, A., Steiner, G., Ambros, P. F., Gadner, H. (1994) Flow cytometric assessment of human MIC 2 expression in bone marrow, thymus, and peripheral blood. Blood 83, 415-425.
3. Hahn, J. H., Kim, M. K., Choi, E. Y., Kim, S. H., Sohn, H. W., Ham, D. I., Chung, D. H., Kim, T. J., Lee, W. J., Park, C. K., Ree, H. J., Park, S. H. (1997) CD99 (MIC2) regulates the LFA-1/ICAM-1-mediated adhesion of lymphocytes, and its gene encodes both positive and negative regulators of cellular adhesion. J. Immunol. 159, 2250-2258.
4. Lee, H. J., Kim, E., Jee, B., Hahn, J. H., Han, K., Jung, K. C., Park, S. H., Lee, H. (2002) Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells. Exp. Mol. Med. 34, 177-183.
5. Alberti, I., Bernard, G., Rouquette-Jazdanian, A. K., Pelassy, C., Pourtein, M., Aussel, C., Bernard, A. (2002) CD99 isoform expression dictates T-cell functional outcomes. FASEB J. 16, 1946-1948.
6. Kovar, H., Dworzak, M., Strehl, S., Schnell, E., Ambros, I. M., Ambros, P. F., Gadner, H. (1990) Overexpression of the pseudoautosomal gene MIC2 in Ewing sarcoma and peripheral primitive neuroectodermal tumor. Oncogene 5, 1067-1070.
7. Ambros, I. M., Ambros, P. F., Strehl, S., Kovar, H., Gadner, H., Salzer-Kuntschik, M. (1991) MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Cancer 67, 1886-1893.
8. Robertson, P. B., Neiman, R. S., Worapongpaiboon, S., John, K., Orazi, A. (1997) 013 (CD99) Positivity in hematologic proliferations correlates with TdT positivity. Mod. Pathol. 10, 277-282. (Pubitemid 27228873)
9. Dorfman, D. M., Kraus, M., Perez-Atayde, A. R., Barnhill, R. L., Pinkus, G. S., Granter, S. R. (1997) CD99 (p30/32MIC2) immunoreactivity in the diagnosis of leukemia cutis. Mod. Pathol. 10, 283-288. (Pubitemid 27228874)
10. Zhang, P. J., Barcos, M., Stewart, C. C., Block, A. W., Sait, S., Brooks, J. J. (2000) Immunoreactivity of MIC2 (CD99) in acute myelogenous leukemia and related diseases. Mod. Pathol. 13, 452-458.
11. Bernard, G., Breittmayer, J. P., de Matteis, M., Trampont, P., Hofman, P., Senik, A. (1997) Apoptosis of immature thymocytes mediated by E2/CD99. J. Immunol. 158, 2543-2550.
12. Scotlandi, K., Baldini, N., Cerisano, V., Manara, M. C., Benini, S., Serra, M., Lollini, P. L., Nanni, P., Nicoletti, G., Bernard, G., Bernard, A., Picci, P. (2000) CD99 engagement: an effective therapeutic strategy for Ewing tumors. Cancer Res. 60, 5134-5142.
13. Scotlandi, K., Perdichizzi, S., Bernard, G., Nicoletti, G., Nanni, P., Lollini, P. L., Curti, A., Manara, M. C., Benini, S., Bernard, A., Picci, P. (2006) Targeting CD99 in association with doxorubicin: an effective combined treatment for Ewing's sarcoma. Eur. J. Cancer 42, 91-96. (Pubitemid 41814537)
14. Dworzak, M. N., Fritsch, G., Fleischer, C., Printz, D., Fröschl, G., Buchinger, P., Mann, G., Gadner, H. (1998) Comparative phenotype mapping of normal vs. malignant pediatric B lymphopoiesis unveils leukemia-associated aberrations. Exp. Hematol. 26, 305-313. (Pubitemid 28177788)
15. Dworzak, M. N., Fritsch, G., Fleischer, C., Printz, D., Fröschl, G., Buchinger, P., Mann, G., Gadner, H. (1999) CD99 (MIC2) expression in pediatric B-lineage leukemia/lymphoma reflects maturation-associated patterns of normal B-lymphopoiesis. Br. J. Haematol. 105, 690-695. (Pubitemid 29277027)
16. Kim, S. H., Choi, E. Y., Shin, Y. K., Kim, T. J., Chung, D. H., Chang, S. I., Kim, N. K., Park, S. H. (1998) Generation of cells with Hodgkin's and Reed-Sternberg phenotype through downregulation of CD99 (MIC2). Blood 92, 4287-4295.
17. Kim, S. H., Shin, Y. K., Lee, I. S., Bae, Y. M., Sohn, H. W., Suh, Y. H., Ree, H. J., Rowe, M., Park, S. H. (2000) Viral latent membrane protein 1 (LMP-1)-induced CD99 down-regulation in B cells leads to the generation of cells with Hodgkin's and Reed-Sternberg phenotype. Blood 95, 294-300. (Pubitemid 30017255)
18. + thymocytes. J. Immunol. 154, 26-32.
19. Yeoh, E. J., Ross, M. E., Shurtleff, S. A., Williams, W. K., Patel, D., Mahfouz, R., Behm, F. G., Raimondi, S. C., Relling, M. V., Patel, A., Cheng, C., Campana, D., Wilkins, D., Zhou, X., Li, J., Liu, H., Pui, C. H., Evans, W. E., Naeve, C., Wong, L., Downing, J. R. (2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1, 133-143.
20. Andersson, A., Olofsson, T., Lindgren, D., Nilsson, B., Ritz, C., Edén, P., Lassen, C., Råde, J., Fontes, M., Mörse, H., Heldrup, J., Behrendtz, M., Mitelman, F., Höglund, M., Johansson, B., Fioretos, T. (2005) Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations. Proc. Natl. Acad. Sci. USA 102, 19069-19074.
21. Manabe, A., Murti, K. G., Coustain-Smith, E., Kumagai, M., Behm, F. G., Raimondi, S. C., Campana, D. (1994) Adhesion-dependent survival of normal and leukemic human B lymphoblasts on bone marrow stromal cells. Blood 83, 758-766. (Pubitemid 24043737)
22. Campana, D., Costain-Smith, E., Kumagai, M. A., Manabe, A. (1994) Growth requirements of normal and leukemic human B cell progenitors. Leuk. Lymphoma 13, 359-371. (Pubitemid 24158955)
23. Matsunaga, T., Takemoto, N., Sato, T., Takimoto, R., Tanaka, I., Fujimi, A., Akiyama, T., Kuroda, H., Kawano, Y., Kobune, M., Kato, J., Hirayama, Y., Sakamaki, S., Kohda, K., Miyake, K., Niitsu, Y. (2003) Interaction between leukemia-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat. Med. 9, 1158-1165.
24. Konopleva, M., Konoplev, S., Hu, W., Zaritsky, A. Y., Afanasiev, B. V., Andreeff, M. (2002) Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia 16, 1713-1724.
25. Ishikawa, F., Yoshida, S., Saito, Y., Hijikata, A., Kitamura, H., Tanaka, S., Nakamura, R., Tanaka, T., Tomiyama, H., Saito, N., Fukata, M., Miyamoto, T., Lyons, B., Ohshima, K., Uchida, N., Taniguchi, S., Ohara, O., Akashi, K., Harada, M., Shultz, L. D. (2007) Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat. Biotechnol. 25, 1315-1321.
26. Mihara, K., Imai, C., Coustan-Smith, E., Dome, J. S., Dominici, M., Vanin, E., Campana, D. (2003) Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase. Br. J. Haematol. 120, 846-849. (Pubitemid 36315109)
27. Nishigaki, H., Ito, C., Manabe, A., Kumagai, M., Coustan-Smith, E., Yanishevski, Y., Behm, F. G., Raimondi, S. C., Pui, C. H., Campana, D. (1997) Prevalence and growth characteristics of malignant stem cells in B-lineage acute lymphoblastic leukemia. Blood 89, 3735-3744. (Pubitemid 27227097)
28. Gaipa, G., Basso, G., Maglia, O., Leoni, V., Faini, A., Cazzaniga, G., Bugarin, C., Veltroni, M., Michelotto, B., Ratei, R., Coliva, T., Valsecchi, M. G., Biondi, A., Dworzak, M. N., I-BFM-ALL-FCM-MRD Study Group (2005) Drug-induced immunophenotypic modulation in childhood ALL: implications for minimal residual disease detection. Leukemia 19, 49-56.
29. Lenkei, R., Gratama, J. W., Rothe, G., Schmitz, G., D'hautcourt, J. L., Arekrans, A., Mandy, F., Marti, G. (1998) Performance of calibration standards for antigen quantitation with flow cytometry. Cytometry 33, 188-196.
30. Hübl, W., Iturraspe, J., Martinez, G. A., Hutcheson, C. E., Roberts, C. G., Fisk, D. D., Sugrue, M. W., Wingard, J. R., Braylan, R. C. (1998) Measurement of absolute concentration and viability of CD34+ cells in cord blood and cord blood products using fluorescent beads and cyanine nucleic acid dyes. Cytometry 34, 121-127.
31. Watzinger, F., Suda, M., Preuner, S., Baumgartinger, R., Ebner, K., Baskova, L., Niesters, H. G., Lawitschka, A., Lion, T. (2004) Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients. J. Clin. Microbiol. 42, 5189-5198. (Pubitemid 39506229)
32. Pui, C. H., Rivera, G. K., Hancock, M. L., Raimondi, S. C., Sandlund, J. T., Mahmoud, H. H., Ribeiro, R. C., Furman, W. L., Hurwitz, C. A., Crist, W. M., Behm, F. G. (1993) Clinical significance of CD10 expression in childhood acute lymphoblastic leukemia. Leukemia 7, 35-40. (Pubitemid 23048918)
33. De Zen, L., Orfao, A., Cazzaniga, G., Masiero, L., Cocito, M. G., Spinelli, M., Rivolta, A., Biondi, A., Zanesco, L., Basso, G. (2000) Quantitative multiparametric immunophenotyping in acute lymphoblastic leukemia: correlation with specific genotype. I. ETV6/AML1 ALLs identification. Leukemia 14, 1225-1231. (Pubitemid 30445029)
34. Hahn, M. J., Yoon, S. S., Sohn, H. W., Song, H. G., Park, S. H., Kim, T. J. (2000) Differential activation of MAP kinase family members triggered by CD99 engagement. FEBS Lett. 470, 350-354.
35. Jung, K. C., Kim, N. H., Park, W. S., Park, S. H., Bae, Y. (2003) The CD99 signal enhances Fas-mediated apoptosis in the human leukemic cell line, Jurkat. FEBS Lett. 554, 478-484.
36. Cerisano, V., Aalto, Y., Perdichizzi, S., Bernard, G., Manara, M. C., Benini, S., Cenacchi, G., Preda, P., Lattanzi, G., Nagy, B., Knuutila, S., Colombo, M. P., Bernard, A., Picci, P., Scotlandi, K. (2004) Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators. Oncogene 23, 5664-5674.
37. Ito, C., Kumagai, M., Manabe, A., Coustan-Smith, E., Raimondi, S. C., Behm, F. G., Murti, K. G., Rubnitz, J. E., Pui, C. H., Campana, D. (1999) Hyperdipolid acute lymphoblastic leukemia with 51 to 65 chromosomes: a distinct biological entity with a marked propensity to undergo apoptosis. Blood 93, 315-320. (Pubitemid 29019418)
38. Shin, Y. K., Lee, G. K., Kook, M. C., Jung, K. C., Kim, J. R., Song, H. G., Park, S. H., Chi, J. G. (1999) Reduced expression of CD99 and functional disturbance in anencephalic cortical thymocytes. Virchows Arch. 434, 443-449.
39. Rolink, A. G., Schaniel, C., Andersson, J., Melchers, F. (2001) Selection events operating at various stages in B cell development. Curr. Opin. Immunol. 13, 202-207. (Pubitemid 32176040)
40. Takahama, Y. (2006) Journey through the thymus: stromal guides for T-cell development and selection. Nat. Rev. Immunol. 6, 127-135.
41. Lee, I., Kim, M. K., Choi, E. Y., Mehl, A., Jung, K. C., Gil, M. C., Rowe, M., Park, S. H. (2001) CD99 expression is positively regulated by Sp1 and is negatively regulated by Epstein-Barr virus latent membrane protein 1 through nuclear factor-κ B. Blood 97, 3596-3604.
42. Brennan, P., Flöttmann, J. E., Mehl, A., Jones, M., Rowe, M. (2001) Mechanism of action of a novel latent membrane protein-1 dominant negative. J. Biol. Chem. 276, 1195-1203.
43. Lam, N., Sugden, B. (2003) LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments. EMBO J. 22, 3027-3038.
44. Kasinrerk, W., Tokrasinwit, N., Moonsom, S., Stockinger, H. (2000) CD99 monoclonal antibody induce homotypic adhesion of Jurkat cells through protein tyrosine kinase and protein kinase C-dependent pathway. Immunol. Lett. 71, 33-41. (Pubitemid 30068609)
45. Attarbaschi, A., Mann, G., König, M., Dworzak, M. N., Trebo, M. M., Mühlegger, N., Gadner, H., Haas, O. A., Austrian Berlin-Frankfurt- Münster Cooperative Study Group (2004) Incidence and relevence of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis. Leukemia 18, 1611-1616.