Intensified neuronal investment in the processing of chemosensory anxiety signals in non-socially anxious and socially anxious individuals

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Pause, Bettina M ^a   Lübke, Katrin ^a   Laudien, Joachim H ^b   Ferstl, Roman ^b  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ATTENTION; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DEFENSE MECHANISM; ERGOMETRY; EVENT RELATED POTENTIAL; FEAR; FEMALE; FRONTAL CORTEX; HUMAN; INFORMATION PROCESSING; LATENT PERIOD; MALE; NEOCORTEX; NERVE CELL; OLFACTORY DISCRIMINATION; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SMELLING; SOCIAL PHOBIA; STIMULUS RESPONSE; SWEAT; ANXIETY; CHEMISTRY; FRONTAL LOBE; PHYSIOLOGY; TIME;

PHEROMONE;

ANXIETY; FEMALE; FRONTAL LOBE; HUMANS; MALE; NEURONS; PHEROMONES, HUMAN; SEX FACTORS; SWEAT; TIME FACTORS; YOUNG ADULT;

EID: 77956409311     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010342     Document Type: Article

References (56)

1. Fanselow MS (1985) Odors released by stressed rats produce opioid analgesia in unstressed rats. Behav Neurosci 99: 589-592.
2. Kikusui T, Takigami S, Takeuchi Y, Mori Y (2001) Alarm pheromone enhances stress-induced hyperthermia in rats. Physiol Behav 72: 45-50.
3. Moynihan JA, Karp JD, Cohen N, Ader R (2000) Immune deviation following stress odor exposure: role of endogenous opioids. J Neuroimmunol 102: 145-153.
4. Wyatt TD (2003) Pheromones and Animal Behaviour. Cambridge: Cambridge University Press.
5. Suh GS, Wong AM, Hergarden AC, Wang JW, Simon AF, et al. (2004) A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila. Nature 431: 854-859.
6. Zalaquett C, Thiessen D (1991) The effects of odors from stressed mice on conspecific behaviour. Physiol Behav 50: 221-227.
7. Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, et al. (2007) Innate versus learned odour processing in the mouse olfactory bulb. Nature 450: 503-508.
8. Liberles SD, Buck LB (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature 442: 645-650.
9. Kiyokawa Y, Kikusui T, Takeuchi Y, Mori Y (2007) Removal of the vomeronasal organ blocks the stress-induced hyperthermia response to alarm pheromone in male rats. Chem Senses 32: 57-64.
10. Brechbühl J, Klaey M, Broillet MC (2008) Grueneberg ganglion cells mediate alarm pheromone detection in mice. Science 321: 1092-1095.
11. Prehn-Kristensen A, Wiesner C, Bergmann TO, Wolff S, Jansen O, et al. (2009) Induction of empathy by the smell of anxiety. PLoS One 4: e5987.
12. Mujica-Parodi LR, Strey HH, Frederick B, Savoy R, Cox D, et al. (2009) Chemosensory cues to conspecific emotional stress activate amygdala in humans. PLoS One 4: e6415.
13. Pause BM, Ohrt A, Prehn A, Ferstl R (2004) Positive emotional priming of facial affect perception in females is diminished by chemosensory anxiety signals. Chem Senses 29: 797-805.
14. Zhou W, Chen D (2009) Fear-related chemosignals modulate recognition of fear in ambiguous facial expressions. Psychol Sci 20: 177-183.
15. Pause BM, Adolph D, Prehn-Kristensen A, Ferstl R (2009) Startle response potentiation to chemosensory anxiety signals in socially anxious individuals. Int J Psychophysiol 74: 88-92.
16. Prehn A, Ohrt A, Sojka B, Ferstl R, Pause BM (2006) Chemosensory anxiety signals augment the startle reflex in humans. Neurosci Letters 394: 127-130.
17. Inagaki H, Kiyokawa Y, Kikusui T, Takeuchi Y, Mori Y (2008) Enhancement of the acoustic startle reflex by an alarm pheromone in male rats. Physiol Behav 93: 606-611.
18. Inagaki H, Nakamura K, Kiyokawa Y, Kikusui T, Takeuchi Y, et al. (2009) The volatility of an alarm pheromone in male rats. Physiol Behav 96: 749-752.
19. Ackerl K, Atzmueller M, Grammer K (2002) The scent of fear. Neuroendocrinol Letters 23: 79-84.
20. Chen D, Haviland-Jones J (2000) Human olfactory communication of emotion. Percept Motor Skills 91: 771-781.
21. Hirsch CR, Clark DM (2004) Information-processing bias in social phobia. Clin Psychol Rev 24: 799-825.
22. Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, et al. (2008) Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry 165: 1193-1202.
23. Pause BM, Krauel K, Sojka B, Ferstl R (1999) Body odor evoked potentials: a new method to study the chemosensory perception of self and non-self in humans. Genetica 104: 285-294.
24. Wittchen HU, Zaudig M, Fydrich T (1997) SKID. Strukturiertes Klinisches Interview für DSM-IV. Göttingen: Hogrefe.
25. Stangier U, Heidenreich T, Berardi A, Golbs U, Hoyer J (1999) Die Erfassung sozialer Phobie durch die Social Interaction Anxiety Scale (SIAS) und die Social Phobia Scale (SPS). Z Klin Psychol Psychother 28: 28-36.
26. Hautzinger M, Bailer M, Worall H, Keller F (1995) Beck-Depressions-Inventar (BDI). Testhandbuch. Bern: Hans Huber.
27. Borkenau P, Ostendorf F (1993) NEO-Fünf-Faktoren Inventar (NEO-FFI) nach Costa und McCrae. Göttingen: Hogrefe.
28. Kobal G (2003) Electrophysiological measurement of olfactory function. In: Doty RL, ed. Handbook of Olfaction and Gustation, 2nd ed. New York: Marcel Dekker. pp 229-250.
29. Pause BM, Krauel K, Sojka B, Ferstl R (1999) Is odor processing related to oral breathing? Int J Psychophysiol 32: 251-260.
30. Gratton G, Coles MG, Donchin E (1983) A new method for off-line removal of ocular artifact. Electroenc Clin Neurophysiol 55: 468-484.
31. Pause BM, Krauel K (2000) Chemosensory event-related potentials (CSERP) as a key to the psychology of odors. Int J Psychophysiol 36: 105-122.
32. Page MC, Braver SL, Kinnon DP (2003) Levine's guide to SPSS for analysis of variance. New Jersey: Lawrence Erlbaum Associates.
33. Perrin F, Pernier J, Bertrand O, Echallier JF (1989) Spherical splines for scalp potential and current density mapping. Electroenc Clin Neurophysiol 72: 184-187.
34. Olofsson JK, Nordin S (2004) Gender differences in chemosensory perception and event-related potentials. Chem Senses 29: 629-637.
35. Orozco S, Ehlers CL (1998) Gender differences in electrophysiological responses to facial stimuli. Biol Psychiatry 44: 281-289.
36. Stuck BA, Frey S, Freiburg C, Hörmann K, Zahnert T, et al. (2006) Chemosensory event-related potentials in relation to side of stimulation, age, sex, and stimulus concentration. Clin Neurophysiol 117: 1367-1375.
37. Rozenkrants B, Polich J (2008) Affective ERP processing in a visual oddball task: arousal, valence, and gender. Clin Neurophysiol 119: 2260-2265.
38. Proverbio AM, Zani A, Adorni R (2008) Neural markers of a greater female responsiveness to social stimuli. BMC Neurosci 9: 56.
39. Li H, Yuan J, Lin C (2008) The neural mechanism underlying the female advantage in identifying negative emotions: An event-related potential study. Neuroimage 40: 1921-1929.
40. Schirmer A, Striano T, Friederici AD (2005) Sex differences in the preattentive processing of vocal emotional expressions. Neuroreport 16: 635-639.
41. Laudien JH, Wencker S, Ferstl R, Pause BM (2008) Context effects on odor processing: an event-related potential study. Neuroimage 41: 1426-1436.
42. Phan KL, Wager T, Taylor SF, Liberzon I (2002) Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 16: 331-348.
43. Damasio AR (1994) Descartes' Error. Emotion, Reason and the Human Brain. New York: Avon Books.
44. Rolls ET (1999) The Brain and Emotion. Oxford: Oxford University Press.
45. Kolassa IT, Kolassa S, Bergmann S, Lauche R, Dilger S, et al. (2009) Interpretive bias in social phobia: an ERP study with morphed emotional schematic faces. Cogn Emot 23: 69-95.
46. Mueller EM, Hofmann SG, Santesso DL, Meuret AE, Bitran S, et al. (2009) Electrophysiological evidence of attentional biases in social anxiety disorder. Psychol Med 39: 1141-1152.
47. Kolassa IT, Miltner WHR (2006) Psychophysiological correlates of face processing in social phobia. Brain Res 1118: 130-141.
48. Moser JS, Huppert JD, Duval E, Simons RF (2008) Face processing biases in social anxiety: an electrophysiological study. Biol Psychol 78: 93-103.
49. Birbaumer N, Grodd W, Diedrich O, Klose U, Erb M, et al. (1998) fMRI reveals amygdala activation to human faces in social phobics. Neuroreport 9: 1223-1226.
50. Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME (2006) Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol Psychiatry 59: 424-429.
51. Straube T, Kolassa IT, Glauer M, Mentzel HJ, Miltner WH (2004) Effect of task conditions on brain responses to threatening faces in social phobics: an eventrelated functional magnetic resonance imaging study. Biol Psychiatry 56: 921-930.
52. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, et al. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62: 593-602.
53. Stein MB, Stein DJ (2008) Social anxiety disorder. Lancet 371: 1115-1125.
54. Morgan CD, Covington JW, Geisler MW, Polich J, Murphy C (1997) Olfactory event-related potentials: older males demonstrate the greatest deficits. Electro-encephalogr Clin Neurophysiol 104: 351-358.
55. McClintock MK (2002) Pheromones, odors, and vasanas: The neuroendocrinology of social chemosignals in humans and animals. In: Pfaff D, Arnold A, Etgen A, Rubin R, Fahrbach S, eds. Hormones, Brain & Behavior. San Diego: Academic Press. pp 797-870.
56. Kiyokawa Y, Kikusui T, Takeuchi Y, Mori Y (2005) Mapping the neural circuit activated by alarm pheromone perception by c-Fos immunohistochemistry. Brain Res 1043: 145-154.