Enhanced induction of mucin-depleted foci in estrogen receptor β knockout mice

Cancer Prevention Research

Volumn 3, Issue 9, 2010, Pages 1198-1204

  Saleiro, Diana ^a,b   Murillo, Genoveva ^a   Lubahn, Dennis B ^c   Kopelovich, Levy ^d   Korach, Kenneth S ^e   Mehta, Rajendra G ^a  

^a IIT RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSITY OF MISSOURI   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCIAN BLUE; AZOXYMETHANE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; METHYLENE BLUE; MUCIN; NEUTRAL RED;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; FEMALE; INTESTINE CRYPT; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRECANCER; PRIORITY JOURNAL;

ABERRANT CRYPT FOCI; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; ESTROGEN RECEPTOR BETA; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCINS; NEOPLASMS, MULTIPLE PRIMARY; PRECANCEROUS CONDITIONS; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 77956405669     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-10-0044     Document Type: Article

References (38)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49.
2. Newcomb PA, Zheng Y, Chia VM, et al. Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women. Cancer Res 2007;67:7534-9. (Pubitemid 47206584)
3. Wernli KJ, Wang Y, Zheng Y, Potter JD, Newcomb PA. The relationship between gravidity and parity and colorectal cancer risk. J Womens Health (Larchmt) 2009;18:995-1001.
4. Bosetti C, Bravi F, Negri E, La Vecchia C. Oral contraceptives and colorectal cancer risk: a systematic review and meta-analysis. Hum Reprod Update 2009;15:489-98.
5. Kabat GC, Miller AB, Rohan TE. Oral contraceptive use, hormone replacement therapy, reproductive history and risk of colorectal cancer in women. Int J Cancer 2008;122:643-6.
6. McMichael AJ, Potter JD. Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis. J Natl Cancer Inst 1980;65:1201-7.
7. Kennelly R, Kavanagh DO, Hogan AM, Winter DC. Oestrogen and the colon: potential mechanisms for cancer prevention. Lancet Oncol 2008;9:385-91.
8. Couse JF, Korach KS. Estrogen receptor null mice: What have we learned and where will they lead us? Endocr Rev 1999;20:358-417.
9. Hewitt SC, Korach KS. Estrogen receptors: structure, mechanisms and function. Rev Endocr Metab Disord 2002;3:193-200.
10. Campbell-Thompson M, Lynch IJ, Bhardwaj B. Expression of estrogen receptor (ER) subtypes and ERβ isoforms in colon cancer. Cancer Res 2001;61:632-40. (Pubitemid 32128626)
11. Konstantinopoulos PA, Kominea A, Vandoros G, et al. Oestrogen receptor β is abundantly expressed in normal colonic mucosa, but declines in colon adenocarcinoma paralleling the tumour's dedifferentiation. Eur J Cancer 2003;39:1251-8.
12. Bardin A, Boulle N, Lazennec G, Vignon F, Pujol P. Loss of ERβ expression as a common step in estrogen-dependent tumor progression. Endocr Relat Cancer 2004;11:537-51.
13. Zhai RL, Wang GB, Cai KL, et al. Transcriptional inactivation of ERβ gene is mediated by the induction of promoter hypermethylation in a rat colonic epithelial cell model. J Surg Res 2009;155:306-10.
14. Tominaga K, Fujii S, Mukawa K, et al. Prediction of colorectal neoplasia by quantitative methylation analysis of estrogen receptor gene in nonneoplastic epithelium from patients with ulcerative colitis. Clin Cancer Res 2005;11:8880-5.
15. Rody A, Holtrich U, Solbach C, et al. Methylation of estrogen receptor β promoter correlates with loss of ER-β expression in mammary carcinoma and is an early indication marker in premalignant lesions. Endocr Relat Cancer 2005;12:903-16.
16. Hartman J, Edvardsson K, Lindberg K, et al. Tumor repressive functions of estrogen receptor β in SW480 colon cancer cells. Cancer Res 2009;69:6100-6.
17. Walker VR, Korach KS. Estrogen receptor knockout mice as a model for endocrine research. ILAR J 2004;45:455-61.
18. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci U S A 1993;90:11162-6.
19. Krege JH, Hodgin JB, Couse JF, et al. Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc Natl Acad Sci U S A 1998;95:15677-82.
20. Bird RP. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer Lett 1987;37:147-51.
21. Murillo G, Kosmeder JW II, Pezzuto JM, Mehta RG. Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 mice. Int J Cancer 2003;104:7-11. (Pubitemid 36184141)
22. Murillo G, Hirschelman WH, Ito A, et al. Zapotin, a phytochemical present in a Mexican fruit, prevents colon carcinogenesis. Nutr Cancer 2007;57:28-37.
23. Caderni G, Femia AP, Giannini A, et al. Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats: correlation with carcinogenesis. Cancer Res 2003;63:2388-92.
24. Yoshimi N, Morioka T, Kinjo T, et al. Histological and immunohistochemical observations of mucin-depleted foci (MDF) stained with Alcian blue, in rat colon carcinogenesis induced with 1,2-dimethylhydrazine dihydrochloride. Cancer Sci 2004;95:792-7.
25. Femia AP, Giannini A, Fazi M, et al. Identification of mucin depleted foci in the human colon. Cancer Prev Res 2008;1:562-7.
26. Mori H, Hata K, Yamada Y, Kuno T, Hara A. Significance and role of early-lesions in experimental colorectal carcinogenesis. Chem Biol Interact 2005;155:1-9. (Pubitemid 40835985)
27. Femia AP, Dolara P, Caderni G. Mucin-depleted foci (MDF) in the colon of rats treated with azoxymethane (AOM) are useful biomarkers for colon carcinogenesis. Carcinogenesis 2004;25:277-81.
28. Murillo G, Mehta RG. Chemoprevention of chemically-induced mammary and colon carcinogenesis by 1α-hydroxyvitamin D5. J Steroid Biochem Mol Biol 2005;97:129-36.
29. Femia AP, Dolara P, Giannini A, Salvadori M, Biggeri A, Caderni G. Frequent mutation of Apc gene in rat colon tumors and mucindepleted foci, preneoplastic lesions in experimental colon carcinogenesis. Cancer Res 2007;67:445-9.
30. Matusiak D, Murillo G, Carrol RE, Mehta RG, Benya RV. Expression of vitamin D receptor and 25-hydroxyvitamin D3-1α-hydroxylase in normal and malignant human colon. Cancer Epidemiol Biomarkers Prev 2005;14:2370-6.
31. Matkowskyj KA, Cox R, Jensen RT, Benya RV. Quantitative immunohistochemistry by measuring cumulative signal strength accurately measures protein concentration. J Histochem Cytochem 2003;51:205-14. (Pubitemid 36160047)
32. Matkowskyj K, Glover S, Benya RV. Quantitative immunohistochemistry: an algorithm measuring cumulative signal strength and receptor number. Microsc Anal 2004;18:5-6.
33. Wada-Hiraike O, Imamov O, Hiraike H, et al. Role of estrogen receptor β in colonic epithelium. Proc Natl Acad Sci U S A 2006;103:2959-64.
34. Weyant MJ, Carothers AM, Mahmoud NN, et al. Reciprocal expression of ERα and ERβ is associated with estrogen-mediated modulation of intestinal tumorigenesis. Cancer Res 2001;61:2547-51.
35. Cho NL, Javid SH, Carothers AM, Redston M, Bertagnolli MM. Estrogen receptors α and β are inhibitory modifiers of Apc-dependent tumorigenesis in the proximal colon of Min/+ mice. Cancer Res 2007;67:2366-72. (Pubitemid 46437055)
36. Cleveland AG, Oikarinen SI, Bynoté KK, et al. Disruption of estrogen receptor signaling enhances intestinal neoplasia in Apc(Min/+) mice. Carcinogenesis 2009;30:1581-90.
37. Weige CC, Allred KF, Allred CD. Estradiol alters cell growth in non-malignant colonocytes and reduces the formation of preneoplastic lesions in the colon. Cancer Res 2009;69:9118-24.
38. Renouf M, Murillo G, Mehta RG, Welsh J. VDR ablation alters basal gene expression and exacerbates AOM-induced aberrant crypt foci in colon of C57 female mice. FASEB J 2007;21:856.6.