Attenuation of reactive gliosis does not affect infarct volume in neonatal hypoxic-ischemic brain injury in mice

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Järlestedt, Katarina ^a   Rousset, Catherine I ^b   Faiz, Maryam ^a   Wilhelmsson, Ulrika ^a   Stahlberg, Anders ^a   Sourkova, Hana ^a   Pekna, Marcela ^a   Mallard, Carina ^a   Hagberg, Henrik ^a,b   Pekny, Milos ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; PROTEIN S 100; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; CELL COUNT; CELL SURVIVAL; CONTROLLED STUDY; GLIOSIS; LEFT HEMISPHERE; MOUSE; NERVE CELL; NEWBORN; NONHUMAN; RIGHT HEMISPHERE; WILD TYPE; ANIMAL; BRAIN INFARCTION; HYPOXIC ISCHEMIC ENCEPHALOPATHY; MOUSE MUTANT; PATHOLOGY;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN INFARCTION; CELL SURVIVAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HYPOXIA-ISCHEMIA, BRAIN; MICE; MICE, KNOCKOUT; NEURONS;

EID: 77956403252     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010397     Document Type: Article

References (32)

1. Chen Y, Swanson RA (2003) Astrocytes and brain injury. J Cereb Blood Flow Metab 23: 137-149.
2. Jing R, Wilhelmsson U, Goodwill W, Li L, Pan Y, et al. (2007) Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. J Cell Sci 120: 1267-1277.
3. Pekny M, Nilsson M (2005) Astrocyte activation and reactive gliosis. Glia 50: 427-434.
4. Chen Y, Vartiainen NE, Ying W, Chan PH, Koistinaho J, et al. (2001) Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism. J Neurochem 77: 1601-1610.
5. Iwata-Ichikawa E, Kondo Y, Miyazaki I, Asanuma M, Ogawa N (1999) Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis. J Neurochem 72: 2334-2344.
6. Silver J, Miller JH (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5: 146-156.
7. Pekny M (2001) Astrocytic intermediate filaments: lessons from GFAP and vimentin knock-out mice. Prog Brain Res 132: 23-30.
8. Pekny M, Johansson CB, Eliasson C, Stakeberg J, Wallen A, et al. (1999) Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin. J Cell Biol 145: 503-514.
9. Pekny M, Pekna M (2004) Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol 204: 428-437.
10. Eliasson C, Sahlgren C, Berthold CH, Stakeberg J, Celis JE, et al. (1999) Intermediate filament protein partnership in astrocytes. J Biol Chem 274: 23996-24006.
11. Wilhelmsson U, Li L, Pekna M, Berthold CH, Blom S, et al. (2004) Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration. J Neurosci 24: 5016- 5021.
12. Hedtjarn M, Leverin AL, Eriksson K, Blomgren K, Mallard C, et al. (2002) Interleukin-18 involvement in hypoxic-ischemic brain injury. J Neurosci 22: 5910-5919.
13. Rice JE, 3rd, Vannucci RC, Brierley JB (1981) The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann Neurol 9: 131-141.
14. Sheldon RA, Sedik C, Ferriero DM (1998) Strain-related brain injury in neonatal mice subjected to hypoxia-ischemia. Brain Res 810: 114-122.
15. Sullivan SM, Bjorkman ST, Miller SM, Colditz PB, Pow DV (2010) Structural remodeling of gray matter astrocytes in the neonatal pig brain after hypoxia/ ischemia. Glia 58: 181-194.
16. Sen E, Levison SW (2006) Astrocytes and developmental white matter disorders. Ment Retard Dev Disabil Res Rev 12: 97-104.
17. Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, et al. (2008) Protective role of reactive astrocytes in brain ischemia. J Cereb Blood Flow Metab 28: 468-481.
18. Hudome S, Palmer C, Roberts RL, Mauger D, Housman C, et al. (1997) The role of neutrophils in the production of hypoxic-ischemic brain injury in the neonatal rat. Pediatr Res 41: 607-616.
19. McRae A, Gilland E, Bona E, Hagberg H (1995) Microglia activation after neonatal hypoxic-ischemia. Brain Res Dev Brain Res 84: 245-252.
20. Vexler ZS, Yenari MA (2009) Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci 31: 378-393.
21. Johnston MV (2005) Excitotoxicity in perinatal brain injury. Brain Pathol 15: 234-240.
22. Hagberg H (2004) Mitochondrial impairment in the developing brain after hypoxia-ischemia. J Bioenerg Biomembr 36: 369-373.
23. Zhu C, Wang X, Xu F, Bahr BA, Shibata M, et al. (2005) The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ 12: 162-176.
24. Kinouchi R, Takeda M, Yang L, Wilhelmsson U, Lundkvist A, et al. (2003) Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin. Nat Neurosci 6: 863-868.
25. Widestrand A, Faijerson J, Wilhelmsson U, Smith PL, Li L, et al. (2007) Increased neurogenesis and astrogenesis from neural progenitor cells grafted in the hippocampus of GFAP-/- Vim-/- mice. Stem Cells 25: 2619-2627.
26. Larsson A, Wilhelmsson U, Pekna M, Pekny M (2004) Increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of old GFAP(-/-)Vim(-/-) mice. Neurochem Res 29: 2069-2073.
27. Ding M, Eliasson C, Betsholtz C, Hamberger A, Pekny M (1998) Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentin. Brain Res Mol Brain Res 62: 77-81.
28. Anderova M, Kubinova S, Mazel T, Chvatal A, Eliasson C, et al. (2001) Effect of elevated K(+), hypotonic stress, and cortical spreading depression on astrocyte swelling in GFAP-deficient mice. Glia 35: 189-203.
29. Pekny M, Leveen P, Pekna M, Eliasson C, Berthold CH, et al. (1995) Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally. EMBO J 14: 1590-1598.
30. Andersen CL, Jensen JL, Orntoft TF (2004) Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 64: 5245-5250.
31. Nolan T, Hands RE, Bustin SA (2006) Quantification of mRNA using real-time RT-PCR. Nat Protoc 1: 1559-1582.
32. Stahlberg A, Zoric N, Aman P, Kubista M (2005) Quantitative real-time PCR for cancer detection: the lymphoma case. Expert Rev Mol Diagn 5: 221-230.