Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Inoue, Naokazu ^a   Kasahara, Tatsuya ^a   Ikawa, Masahito ^a   Okabe, Masaru ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN CONVERTING ENZYME 2; CHORIONIC GONADOTROPIN; PROTEIN IZUMO1; SPERM ANTIBODY; UNCLASSIFIED DRUG; ACE3 PROTEIN, MOUSE; DIPEPTIDYL CARBOXYPEPTIDASE; IMMUNOGLOBULIN; IZUMO1 PROTEIN, MOUSE; MEMBRANE PROTEIN;

ACROSOME REACTION; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DISRUPTION; CHROMATOGRAPHY; EGG; FEMALE; FERTILIZATION IN VITRO; HOMOLOGOUS RECOMBINATION; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN INTERACTION; SPERM; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE; ACROSOME; ANIMAL; CHEMISTRY; ENZYMOLOGY; FERTILITY; METABOLISM; PROTEIN ANALYSIS; PROTEIN BINDING; SPERMATOZOON; TESTIS;

ACROSOME; ANIMALS; FERTILITY; IMMUNOGLOBULINS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PEPTIDYL-DIPEPTIDASE A; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; SPERMATOZOA; TESTIS;

EID: 77956401827     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010301     Document Type: Article

References (23)

1. Miyado K, Yamada G, Yamada S, Hasuwa H, Nakamura Y, et al. (2000) Requirement of CD9 on the egg plasma membrane for fertilization. Science 287: 321-324.
2. Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C (2000) Severely reduced female fertility in CD9-deficient mice. Science 287: 319-321.
3. Kaji K, Oda S, Shikano T, Ohnuki T, Uematsu Y, et al. (2000) The gamete fusion process is defective in eggs of Cd9-deficient mice. Nat Genet 24: 279-282.
4. Inoue N, Ikawa M, Isotani A, Okabe M (2005) The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 434: 234-238.
5. Ellerman DA, Pei J, Gupta S, Snell WJ, Myles D, et al. (2009) Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol Reprod Dev 76: 1188-1199.
6. Martens S, McMahon HT (2008) Mechanisms of membrane fusion: disparate players and common principles. Nat Rev Mol Cell Biol 9: 543-556.
7. Rella M, Elliot JL, Revett TJ, Lanfear J, Phelan A, et al. (2007) Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. BMC Genomics 8: 194.
8. Hagaman JR, Moyer JS, Bachman ES, Sibony M, Magyar PL, et al. (1998) Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci USA 95: 2552-2557.
9. Kessler SP, Rowe TM, Gomos JB, Kessler PM, Sen GC (2000) Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme. J Biol Chem 275: 26259-26264.
10. Inoue N, Ikawa M, Okabe M (2008) Putative sperm fusion protein IZUMO and the role of N-glycosylation. Biochem Biophys Res Commun 377: 910-914.
11. Kim KS, Cha MC, Gerton GL (2001) Mouse sperm protein sp56 is a component of the acrosomal matrix. Biol Reprod 64: 36-43.
12. Ramalho-Santos J, Moreno RD, Wessel GM, Chan EK, Schatten G (2001) Membrane trafficking machinery components associated with the mammalian acrosome during spermiogenesis. Exp Cell Res 267: 45-60.
13. Yamashita M, Honda A, Ogura A, Kashiwabara S, Fukami K, et al. (2008) Reduced fertility of mouse epididymal sperm lacking Prss21/Tesp5 is rescued by sperm exposure to uterine microenvironment. Genes Cells 13: 1001-1013.
14. Ikawa M, Inoue N, Benham M, Okabe M (2010) Fertilization: a sperm's journey to and interaction with the oocyte. J Clin Invest 120: 984-994.
15. Inoue N, Yamaguchi R, Ikawa M, Okabe M (2007) Sperm-egg interaction and gene manipulated animals. Soc Reprod Fertil Suppl 65: 363-371.
16. Chen EH, Olson EN (2005) Unveiling the mechanisms of cell-cell fusion. Science 308: 369-373.
17. Douglas GC, O'Bryan MK, Hedger MP, Lee DK, Yarski MA, et al. (2004) The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis. Endocrinology 145: 4703-4711.
18. Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, et al. (2002) Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 417: 822-828.
19. Kondoh G, Tojo H, Nakatani Y, Komazawa N, Murata C, et al. (2005) Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med 11: 160-166.
20. Deguchi E, Tani T, Watanabe H, Yamada S, Kondoh G (2007) Dipeptidase-inactivated tACE action in vivo: selective inhibition of sperm-zona pellucida binding in the mouse. Biol Reprod 77: 794-802.
21. Sun X, Wiesner B, Lorenz D, Papsdorf G, Pankow K, et al. (2008) Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE. Biol Chem 389: 1477-1485.
22. Fuchs S, Frenzel K, Hubert C, Lyng R, Muller L, et al. (2005) Male fertility is dependent on dipeptidase activity of testis ACE. Nat Med 11: 1140-1142; author reply 1142-1143.
23. Yamagata K, Nakanishi T, Ikawa M, Yamaguchi R, Moss SB, et al. (2002) Sperm from the calmegin-deficient mouse have normal abilities for binding and fusion to the egg plasma membrane. Dev Biol 250: 348-357.