High expression of the very late antigen-4 integrin independently predicts reduced risk of relapse and improved outcome in pediatric acute myeloid leukemia: A report from the children's oncology group

Journal of Clinical Oncology

Volumn 28, Issue 17, 2010, Pages 2831-2838

  Walter, Roland B ^a   Alonzo, Todd A ^a   Gerbing, Robert B ^a   Ho, Phoenix A ^a   Smith, Franklin O ^a   Raimondi, Susana C ^a   Hirsch, Betsy A ^a   Gamis, Alan S ^a   Franklin, Janet L ^a   Hurwitz, Craig A ^a   Loken, Michael R ^a   Meshinchi, Soheil ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

VERY LATE ACTIVATION ANTIGEN 4;

ACUTE GRANULOCYTIC LEUKEMIA; AGE; ARTICLE; CANCER RELAPSE; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; FLOW CYTOMETRY; HUMAN; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RISK REDUCTION; SCHOOL CHILD; ADOLESCENT; ADULT; BIOSYNTHESIS; COHORT ANALYSIS; IMMUNOLOGY; INFANT; PATHOLOGY; PHASE 3 CLINICAL TRIAL; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGE FACTORS; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS, PHASE III AS TOPIC; COHORT STUDIES; FLOW CYTOMETRY; HUMANS; INFANT; INTEGRIN ALPHA4BETA1; LEUKEMIA, MYELOID, ACUTE; MALE; PROGNOSIS; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77956398973     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2009.27.5693     Document Type: Article

References (17)

1. Hynes RO: Integrins: Bidirectional, allosteric signaling machines. Cell 110:673-687, 2002
2. Takada Y, Ye X, Simon S: The integrins. Genome Biol 8:215, 2007
3. Ley K, Laudanna C, Cybulsky MI, et al: Getting to the site of inflammation: The leukocyte adhesion cascade updated. Nat Rev Immunol 7:678-689, 2007 (Pubitemid 47327397)
4. Abram CL, Lowell CA: The ins and outs of leukocyte integrin signaling. Annu Rev Immunol 27:339-362, 2009
5. Stucki A, Rivier AS, Gikic M, et al: Endothelial cell activation by myeloblasts: Molecular mechanisms of leukostasis and leukemic cell dissemination. Blood 97:2121-2129, 2001 (Pubitemid 32239095)
6. Bendall LJ, Kortlepel K, Gottlieb DJ: Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms. Blood 82:3125-3132, 1993 (Pubitemid 23334940)
7. Burger JA, Spoo A, Dwenger A, et al: CXCR4 chemokine receptors (CD184) and alpha4beta1 integrins mediate spontaneous migration of human CD34+ progenitors and acute myeloid leukaemia cells beneath marrow stromal cells (pseudoemperipolesis). Br J Haematol 122:579-589, 2003 (Pubitemid 37006402)
8. Matsunaga T, Takemoto N, Sato T, et al: Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia. Nat Med 9:1158-1165, 2003 (Pubitemid 37173700)
9. Tavernier-Tardy E, Cornillon J, Campos L, et al: Prognostic value of CXCR4 and FAK expression in acute myelogenous leukemia. Leuk Res 33:764-768, 2009
10. Becker PS, Kopecky KJ, Wilks AN, et al: Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia. Blood 113:866-874, 2009
11. Franklin J, Alonzo T, Hurwitz CA, et al: COG AAML03P1: Efficacy and safety in a pilot study of intensive chemotherapy including gemtuzumab in children newly diagnosed with acute myeloid leukemia (AML). Blood 112:56, 2008 (abstr 136)
12. Wells DA, Loken MR: Flow cytometric mean fluorescence intensity: The biophysics behind the number. Leuk Res 32:845-846, 2008
13. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
14. Kalbfleisch JD, Prentice RL: The Statistical Analysis of Failure Time Data. Hoboken, NJ, John Wiley & Sons, 2002
15. Cox DR: Regression models and life tables. J R Stat Soc B 34:187-220, 1972
16. Südhoff T, Wehmeier A, Kliche KO, et al: Levels of circulating endothelial adhesion molecules (sE-selectin and sVCAM-1) in adult patients with acute leukemia. Leukemia 10:682-686, 1996 (Pubitemid 26144450)
17. Stefanidakis M, Karjalainen K, Jaalouk DE, et al: Role of leukemia cell invadosome in extramedullary infiltration. Blood 114:3008-3017, 2009