Telmisartan, a partial agonist of peroxisome proliferator-activated receptor γ, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia

Brain Research

Volumn 1353, Issue , 2010, Pages 125-132

  Haraguchi, Tamami ^a   Iwasaki, Katsunori ^a   Takasaki, Kotaro ^a   Uchida, Kanako ^a   Naito, Tetsuya ^a   Nogami, Ai ^a   Kubota, Kaori ^a   Shindo, Taro ^a   Uchida, Naoki ^a   Katsurabayashi, Shutaro ^a   Mishima, Kenichi ^a   Nishimura, Ryoji ^a   Fujiwara, Michihiro ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cerebral ischemia; Dementia; GW9662; PPAR ; Telmisartan

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CASPASE 3; TELMISARTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG INHIBITION; HIPPOCAMPUS; MAZE TEST; MEMORY DISORDER; NERVE CELL NECROSIS; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

ANALYSIS OF VARIANCE; ANILIDES; ANIMALS; APOPTOSIS; BENZIMIDAZOLES; BENZOATES; BRAIN ISCHEMIA; CASPASE 3; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; IN SITU NICK-END LABELING; MALE; MAZE LEARNING; MEMORY DISORDERS; PPAR GAMMA; RATS; RATS, WISTAR; SPATIAL BEHAVIOR; TIME FACTORS;

RATTUS;

EID: 77956393248     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.07.017     Document Type: Article

References (27)

1. M. Allahtavakoli, A.P. Shabanzadeh, S.S. Sadr, M. Parviz, and B. Djahanguiri Rosiglitazone, a peroxisome proliferator-activated receptor-gamma ligand, reduces infarction volume and neurological deficits in an embolic model of stroke Clin. Exp. Pharmacol. Physiol. 33 11 2006 1052 1058 (Nov)
2. M. Ankarcrona, J.M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S.A. Lipton, and P. Nicotera Glutamate-induced neuronal death: a succession of neurosis of necrosis or apoptosis depending on mitochondrial function Neuron 15 4 1995 961 973 (Oct)
3. S.C. Benson, H.A. Pershadsingh, C.I. Ho, A. Chittiboyina, P. Desai, M. Pravenec, N. Qi, J. Wang, M.A. Avery, and T.W. Kurtz Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity Hypertension 43 2004 993 1002
4. S.D. Chen, H.Y. Wu, D.I. Yang, S.Y. Lee, F.Z. Shaw, T.K. Lin, C.W. Liou, and Y.C. Chuang Effects of rosiglitazone on global ischemia-induced hippocampal injury and expression of mitochondrial uncoupling protein 2 Biochem. Biophys. Res. Commun. 351 1 2006 198 203 (Dec 8)
5. D.W. Choi Ischemia-induced neuronal apoptosis Curr. Opin. Neurobiol. 6 5 1996 667 672 (Oct)
6. E. Chung, K. Iwasaki, K. Mishima, N. Egashira, and M. Fujiwara Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat Life Sci. 72 2004 609 619
7. K. Fuenzalida, R. Quintanilla, P. Ramos, D. Piderit, R.A. Fuentealba, G. Martinez, N.C. Inestrosa, and M. Bronfman Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis J. Biol. Chem. 282 51 2007 37006 37015 (Dec 21)
8. T. Haraguchi, K. Takasaki, T. Naito, K. Hayakawa, S. Katsurabayashi, K. Mishima, K. Iwasaki, and M. Fujiwara Cerebroprotective action of telmisartan by inhibition of macrophages/microglia expressing HMGB1 via a peroxisome proliferator-activated receptor gamma-dependent mechanism Neurosci. Lett. 464 3 2009 151 155 (Oct 30)
9. M.T. Heneka, and G.E. Landreth PPARs in the brain Biochem Biophys Acta 1771 8 2007 1031 1045 (Aug)
10. M. Horiuchi, M. Mogi, and M. Iwai The angiotensin II type 2 receptor in the brain J Renin Angiotensin Syst. 11 1 2010 1 6
11. K. Irie, K. Mishima, D. Ishibashi, N. Egashira, K. Iwasaki, and M. Fujiwara Involvement of bcl-family expression in the spatial memory impairment induced by repeated ischemia Life Sci. 72 4-5 2002 621 629
12. Iwai, M., Liu, H.W., Chen, R., Ide, A., Okamoto, S., Hata, R., Sakanaka, M, Shiuchi, T., Horiuchi, M., 2004. Possible inhibition of focal cerebral ischemia by angiotensin II type 2 receptor stimulation. 110(7), 843-848.
13. K. Iwasaki, E.H. Chung, N. Egashira, I. Hatip-AI-Khatib, K. Mishima, T. Egawa, K. Irie, and M. Fujiwara Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats Brain Res. 995 1 2004 131 139 (Jan 2)
14. Y. Kumai, H. Ooboshi, T. Ago, E. Ishikawa, J. Takada, M. Kamouchi, T. Kitazono, S. Ibayashi, and M. Iida Protective effects of angiotensin II type 1 receptor blocker on cerebral circulation independent of blood pressure Exp. Neurol. 210 2 2008 441 448 (Apr)
15. T.N. Lin, W.M. Cheung, J.S. Wu, J.J. Chen, H. Lin, J.J. Chen, J.Y. Liou, S.K. Shyue, and K.K. Wu 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury Arterioscler. Thromb. Vasc. Biol. 26 3 2006 481 487 (Mar)
16. S. Moreno, S. Farioli-vecchioli, and M.P. Ceru Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS Neuroscience 123 1 2004 131 145
17. Z. Ou, X. Zhao, L.A. Labiche, R. Strong, J.C. Grotta, O. Herrmann, and J. Aronowski Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) and 15d-prostaglandin J2 - mediated protection of brain after experimental cerebral ischemia in rat Brain Res. 1096 1 2006 196 203 (Jun 22)
18. F. Pu, K. Motohashi, T. Kaneko, Y. Tanaka, N. Manome, K. Irie, J. Takata, N. Egashira, R. Oishi, T. Okamoto, Y. Sei, T. Yokozawa, K. Mishima, K. Iwasaki, and M. Fujiwara Neuroprotective effects of Kangen-karyu on spatial memory impairment in an-8-arm radial maze and neuronal death in the hippocampal CA1 region induced by repeated cerebral ischemia in rats J Phamacol Sci. Mar 109 3 2009 424 430
19. M. Schupp, J. Janke, R. Clasen, T. Unger, and U. Kintscher Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity Circulation 109 2004 2054 2057
20. S. Sundararajan, J.L. Gamboa, N.A. Victor, E.W. Wandeli, W.D. Lust, and G.E. Landreth Peroxisome proliferator-activated receptor-γ ligands reduce inflammation and infarction size in transient focal ischemia Neuroscience 130 3 2005 685 696
21. S. Sundrarajan, Q. Jiang, M. Heneka, and G. Landreth PPARγ as a therapeutic target in central nervous system diseases Neurochem. Int. 49 2 2006 136 144 (Jul)
22. N.A. Victor, E.W. Wanderi, J. Gamboa, X. Zhao, J. Aronowaki, K. Deininger, W.D. Lust, G.E. Landreth, and S. Sundrarajan Altered PPARγ expression and activation after transient focal ischemia in rats Eur. J. Neurosci. 24 6 2006 1653 1663 (Sep)
23. K. Wada, A. Nakajima, K. Katayama, C. Kudo, A. Shibuya, N. Kubota, Y. Terauchi, M. Tachibana, H. Miyoshi, Y. Kamisaki, T. Mayumi, T. Kadowaki, and R.S. Blumberg Peroxisome proliferator-activated receptor gamma-mediated regulation of neural stem cell proliferation and differentiation J. Biol. Chem. 281 18 2006 12673 12681 (May 5)
24. C.X. Wang, X. Ding, R. Noor, C. Pegg, C. He, and A. Shuaib Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats J. Cereb. Blood Flow Metab. 29 10 2009 1683 1694 (Oct)
25. J.S. Wu, W.M. Cheung, Y.S. Tsai, Y.T. Chen, W.H. Fong, H.D. Tsai, Y.C. Chen, J.Y. Liou, S.K. Shyue, J.J. Chen, Y.E. Chen, N. Maeda, K.K. Wu, and T.N. Lin Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation Circulation 119 8 2009 1124 1134 (Mar 3)
26. Y. Zhao, A. Patzer, T. Herdegen, P. Gohlke, and J. Culman Activation of cerebral peroxisome proliferator-activated receptors γ promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 overexpression after focal cerebral ischemia in rats FASEB J. 20 8 2006 1162 1175 (Jun)
27. Y.Z. Zhu, G.N. Chimon, Y.C. Zhu, Q. Lu, B. Li, H.Z. Hu, E.H. Yap, H.S. Lee, and P.T. Wong Expression of angiotensin II AT2 receptor in the acute phase of stroke in rats NeuroReport 11 6 2000 1191 1194 (Apr 27)