Immune mechanisms of sublingual immunotherapy: Are oral Langerhans cells the masters of tolerance?

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 3, 2010, Pages 646-647

  Larché, Mark ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Immune mechanisms; Langerhans cells; sublingual immunotherapy; tolerance

Indexed keywords

ALLERGEN; ALLOANTIGEN;

ANTIGEN SPECIFICITY; BINDING AFFINITY; DENDRITIC CELL; DESENSITIZATION; EDITORIAL; GRASS POLLEN; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOTHERAPY; LANGERHANS CELL; PRIORITY JOURNAL; SUBLINGUAL IMMUNOTHERAPY; IMMUNOLOGY; SUBLINGUAL DRUG ADMINISTRATION;

ADMINISTRATION, SUBLINGUAL; HUMANS; IMMUNE TOLERANCE; IMMUNOTHERAPY; LANGERHANS CELLS;

EID: 77956355605     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.07.027     Document Type: Editorial

References (12)

1. J.P. Allam, P.A. Wurtzen, M. Reinartz, J. Winter, S. Vrtala, and K.W. Chen Phl p 5 resorption in human oral mucosa leads to dose-dependent and time-dependent allergen binding by oral mucosal Langerhans cells, attenuates their maturation, and enhances their migratory and TGF-beta1 and IL-10-producing properties J Allergy Clin Immunol 126 2010 638 645
2. J.P. Allam, N. Novak, C. Fuchs, S. Asen, S. Berge, and T. Appel Characterization of dendritic cells from human oral mucosa: a new Langerhans' cell type with high constitutive FcepsilonRI expression J Allergy Clin Immunol 112 2003 141 148
3. T.A. Borkowski, M.H. Jouvin, S.Y. Lin, and J.P. Kinet Minimal requirements for IgE-mediated regulation of surface FcepsilonRI J Immunol 167 2001 1290 1296
4. M. Wills-Karp, A. Nathan, K. Page, and C.L. Karp New insights into innate immune mechanisms underlying allergenicity Mucosal Immunol 3 2010 104 110
5. A. Trompette, S. Divanovic, A. Visintin, C. Blanchard, R.S. Hegde, and R. Madan Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein Nature 457 2009 585 588
6. G.A. Mueller, L.L. Edwards, J.J. Aloor, M.B. Fessler, J. Glesner, and A. Pomes The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins J Allergy Clin Immunol 125 2010 909 917
7. W.G. Shreffler, R.R. Castro, Z.Y. Kucuk, Z. Charlop-Powers, G. Grishina, and S. Yoo The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro J Immunol 177 2006 3677 3685
8. S.A. Lira A passport into the lymph node Nat Immunol 6 2005 866 868
9. F. Geissmann, P. Revy, A. Regnault, Y. Lepelletier, M. Dy, and N. Brousse TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells J Immunol 162 1999 4567 4575
10. K. Steinbrink, M. Wolfl, H. Jonuleit, J. Knop, and A.H. Enk Induction of tolerance by IL-10-treated dendritic cells J Immunol 159 1997 4772 4780
11. H. Jonuleit, E. Schmitt, G. Schuler, J. Knop, and A.H. Enk Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells J Exp Med 192 2000 1213 1222
12. B. Bohle, T. Kinaciyan, M. Gerstmayr, A. Radakovics, B. Jahn-Schmid, and C. Ebner Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation J Allergy Clin Immunol 120 2007 707 713