-
1
-
-
0030066573
-
Molecular genetic insights into cardiovascular disease
-
10.1126/science.272.5262.681 1:CAS:528:DyaK28Xislamsb4%3D 8614827
-
MT Keating MC Sanguinetti 1996 Molecular genetic insights into cardiovascular disease Science 272 681 685 10.1126/science.272.5262.681 1:CAS:528:DyaK28Xislamsb4%3D 8614827
-
(1996)
Science
, vol.272
, pp. 681-685
-
-
Keating, M.T.1
Sanguinetti, M.C.2
-
2
-
-
0028292927
-
A family of potassium channel genes related to eag in Drosophila and mammals
-
10.1073/pnas.91.8.3438 1:CAS:528:DyaK2cXksFWjt74%3D 8159766
-
JW Warmke B Ganetzky 1994 A family of potassium channel genes related to eag in Drosophila and mammals Proceedings of the National Academy of Sciences of the United States of America 91 3438 3442 10.1073/pnas.91.8.3438 1:CAS:528:DyaK2cXksFWjt74%3D 8159766
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, pp. 3438-3442
-
-
Warmke, J.W.1
Ganetzky, B.2
-
3
-
-
0029002969
-
A mechanistic link between an inherited and an acquired cardiac arrhythmia
-
10.1016/0092-8674(95)90340-2 1:CAS:528:DyaK2MXlt1Kis7w%3D 7736582
-
MC Sanguinetti C Jiang ME Curran MT Keating 1995 A mechanistic link between an inherited and an acquired cardiac arrhythmia Cell 81 299 307 10.1016/0092-8674(95)90340-2 1:CAS:528:DyaK2MXlt1Kis7w%3D 7736582
-
(1995)
Cell
, vol.81
, pp. 299-307
-
-
Sanguinetti, M.C.1
Jiang, C.2
Curran, M.E.3
Keating, M.T.4
-
4
-
-
0029007356
-
HERG, a human inward rectifier in the voltage-gated potassium channel family
-
10.1126/science.7604285 1:CAS:528:DyaK2MXmsl2ju7k%3D 7604285
-
MC Trudeau JW Warmke B Ganetzky GA Robertson 1995 hERG, a human inward rectifier in the voltage-gated potassium channel family Science 269 92 95 10.1126/science.7604285 1:CAS:528:DyaK2MXmsl2ju7k%3D 7604285
-
(1995)
Science
, vol.269
, pp. 92-95
-
-
Trudeau, M.C.1
Warmke, J.W.2
Ganetzky, B.3
Robertson, G.A.4
-
5
-
-
14544268139
-
+ channel blockade: Current knowledge and strategies for the early prediction during drug development
-
10.1002/med.20019 1:CAS:528:DC%2BD2MXitlWhs7Y%3D 15389727
-
+ channel blockade: Current knowledge and strategies for the early prediction during drug development Medicinal Research Reviews 25 133 166 10.1002/med.20019 1:CAS:528:DC%2BD2MXitlWhs7Y%3D 15389727
-
(2005)
Medicinal Research Reviews
, vol.25
, pp. 133-166
-
-
Recanatini, M.1
Poluzzi, E.2
Masetti, M.3
Cavalli, A.4
De Ponti, F.5
-
6
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development
-
10.1016/S0008-6363(02)00846-5 1:CAS:528:DC%2BD3sXit12gsb8%3D 12667944
-
WS Redfern L Carlsson AS Davis WG Lynch I MacKenzie S Palethorpe PK Siegl I Strang AT Sullivan R Wallis AJ Camm TG Hammond 2003 Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development Cardiovascular Research 58 32 45 10.1016/S0008-6363(02)00846-5 1:CAS:528:DC%2BD3sXit12gsb8%3D 12667944
-
(2003)
Cardiovascular Research
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
Palethorpe, S.6
Siegl, P.K.7
Strang, I.8
Sullivan, A.T.9
Wallis, R.10
Camm, A.J.11
Hammond, T.G.12
-
7
-
-
77956340436
-
The nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals
-
International conference on harmonization S7B guideline (CPMP/ICH/423/02; 2005). The nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. http://www.emea.europa.eu/pdfs/human/ich/042302en.pdf.
-
International Conference on Harmonization S7B Guideline (CPMP/ICH/423/02; 2005)
-
-
-
9
-
-
34247210196
-
Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers
-
10.1038/sj.clpt.6100120 1:CAS:528:DC%2BD2sXlsFCqsbc%3D 17329992
-
CB Eap S Crettol J-S Rougier J Schläpfer L Sintra Grilo J-J Deglon J Besson M Croquette-Krokar P-A Carrupt H Abriel 2007 Stereoselective block of hERG channel by (S)-methadone and QT interval prolongation in CYP2B6 slow metabolizers Clinical Pharmacology and Therapeutics 81 719 728 10.1038/sj.clpt.6100120 1:CAS:528:DC%2BD2sXlsFCqsbc%3D 17329992
-
(2007)
Clinical Pharmacology and Therapeutics
, vol.81
, pp. 719-728
-
-
Eap, C.B.1
Crettol, S.2
Rougier, J.-S.3
Schläpfer, J.4
Sintra Grilo, L.5
Deglon, J.-J.6
Besson, J.7
Croquette-Krokar, M.8
Carrupt, P.-A.9
Abriel, H.10
-
11
-
-
55149102596
-
The effects of chiral isolates of methadone on the cardiac potassium channel IKr
-
10.1159/000167043 1:CAS:528:DC%2BD1MXktVGkt7c%3D 18984955
-
C Lin T Somberg J Molnar J Somberg 2009 The effects of chiral isolates of methadone on the cardiac potassium channel IKr Cardiology 113 59 65 10.1159/000167043 1:CAS:528:DC%2BD1MXktVGkt7c%3D 18984955
-
(2009)
Cardiology
, vol.113
, pp. 59-65
-
-
Lin, C.1
Somberg, T.2
Molnar, J.3
Somberg, J.4
-
12
-
-
0019441262
-
Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches
-
10.1007/BF00656997 1:STN:280:DyaL38%2FjslWrug%3D%3D 6270629
-
OP Hamill A Marty E Neher B Sakmann FJ Sigworth 1981 Improved patch-clamp techniques for high-resolution current recordings from cells and cell-free membrane patches Pfluegers Archiv 391 85 100 10.1007/BF00656997 1:STN:280:DyaL38%2FjslWrug%3D%3D 6270629
-
(1981)
Pfluegers Archiv
, vol.391
, pp. 85-100
-
-
Hamill, O.P.1
Marty, A.2
Neher, E.3
Sakmann, B.4
Sigworth, F.J.5
-
14
-
-
0019515320
-
Methadone binding to orosomucoid (alpha 1-acid glycoprotein): Determinant of free fraction in plasma
-
1:CAS:528:DyaL3MXhtlWqt7s%3D 7193106
-
MK Romach KM Piafsky JG Abel V Khouw EM Sellers 1981 Methadone binding to orosomucoid (alpha 1-acid glycoprotein): Determinant of free fraction in plasma Clinical Pharmacology and Therapeutics 29 211 217 1:CAS:528:DyaL3MXhtlWqt7s%3D 7193106
-
(1981)
Clinical Pharmacology and Therapeutics
, vol.29
, pp. 211-217
-
-
Romach, M.K.1
Piafsky, K.M.2
Abel, J.G.3
Khouw, V.4
Sellers, E.M.5
-
16
-
-
3042517214
-
Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone
-
10.1016/j.clpt.2004.03.007 1:CAS:528:DC%2BD2cXlsVaqtrk%3D 15229464
-
M Benmebarek C Devaud M Gex-Fabry K Powell Golay C Brogli P Baumann B Gravier CB Eap 2004 Effects of grapefruit juice on the pharmacokinetics of the enantiomers of methadone Clinical Pharmacology and Therapeutics 76 55 63 10.1016/j.clpt.2004.03.007 1:CAS:528:DC%2BD2cXlsVaqtrk%3D 15229464
-
(2004)
Clinical Pharmacology and Therapeutics
, vol.76
, pp. 55-63
-
-
Benmebarek, M.1
Devaud, C.2
Gex-Fabry, M.3
Powell Golay, K.4
Brogli, C.5
Baumann, P.6
Gravier, B.7
Eap, C.B.8
-
17
-
-
33645501720
-
Population pharmacokinetics of heroin and its major metabolites
-
10.2165/00003088-200645040-00005 1:CAS:528:DC%2BD28XptlCjtrw%3D 16584286
-
EJ Rook ADR Huitema W van den Brink JM van Ree JH Beijnen 2006 Population pharmacokinetics of heroin and its major metabolites Clinical Pharmacokinetics 45 401 417 10.2165/00003088-200645040-00005 1:CAS:528:DC%2BD28XptlCjtrw%3D 16584286
-
(2006)
Clinical Pharmacokinetics
, vol.45
, pp. 401-417
-
-
Rook, E.J.1
Huitema, A.D.R.2
Van Den Brink, W.3
Van Ree, J.M.4
Beijnen, J.H.5
-
20
-
-
14644412444
-
Predicting drug-hERG channel interactions that cause acquired long QT syndrome
-
10.1016/j.tips.2005.01.003 1:CAS:528:DC%2BD2MXitVeisLg%3D 15749156
-
MC Sanguinetti JS Mitcheson 2005 Predicting drug-hERG channel interactions that cause acquired long QT syndrome Trends in Pharmacological Sciences 26 119 124 10.1016/j.tips.2005.01.003 1:CAS:528:DC%2BD2MXitVeisLg%3D 15749156
-
(2005)
Trends in Pharmacological Sciences
, vol.26
, pp. 119-124
-
-
Sanguinetti, M.C.1
Mitcheson, J.S.2
-
21
-
-
33748439683
-
Human ether-a-go-go-related (hERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects
-
10.1016/j.pharmthera.2006.03.002 16647758
-
BJ Zünkler 2006 Human ether-a-go-go-related (hERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects Pharmacology and Therapeutics 112 12 37 10.1016/j.pharmthera.2006.03.002 16647758
-
(2006)
Pharmacology and Therapeutics
, vol.112
, pp. 12-37
-
-
Zünkler, B.J.1
-
22
-
-
0038497465
-
Blockade of hERG potassium currents by fluvoxamine: Incomplete attenuation by S6 mutations at F656 or Y652
-
10.1038/sj.bjp.0705335 1:CAS:528:DC%2BD3sXlvVCjurY%3D 12839862
-
JT Milnes O Crociani A Arcangeli JC Hancox HJ Witchel 2003 Blockade of hERG potassium currents by fluvoxamine: Incomplete attenuation by S6 mutations at F656 or Y652 British Journal of Pharmacology 139 887 898 10.1038/sj.bjp. 0705335 1:CAS:528:DC%2BD3sXlvVCjurY%3D 12839862
-
(2003)
British Journal of Pharmacology
, vol.139
, pp. 887-898
-
-
Milnes, J.T.1
Crociani, O.2
Arcangeli, A.3
Hancox, J.C.4
Witchel, H.J.5
-
23
-
-
0038298482
-
Drug binding to hERG channels: Evidence for a "non-aromatic" binding site for fluvoxamine
-
10.1038/sj.bjp.0705336 1:CAS:528:DC%2BD3sXlvVCjurg%3D 12839860
-
JS Mitcheson 2003 Drug binding to hERG channels: Evidence for a "non-aromatic" binding site for fluvoxamine British Journal of Pharmacology 139 883 884 10.1038/sj.bjp.0705336 1:CAS:528:DC%2BD3sXlvVCjurg%3D 12839860
-
(2003)
British Journal of Pharmacology
, vol.139
, pp. 883-884
-
-
Mitcheson, J.S.1
|