Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na + absorption

British Journal of Pharmacology

Volumn 161, Issue 3, 2010, Pages 571-588

  Mansley, Morag K ^a   Wilson, Stuart M ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Akti 1 2; cortical collecting duct; epithelial Na + channel; GDC 0941; GSK650394A; kinase inhibitors; PI103

Indexed keywords

2 (1H INDAZOL 4 YL) 6 (4 METHANESULFONYL 1 PIPERAZINYLMETHYL) 4 MORPHOLINOTHIENO[3,2 D]PYRIMIDINE; 2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; GSK 650394A; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RAPAMYCIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SERUM AND GLUCOCORTICOID REGULATED KINASE 1 INHIBITOR; SODIUM ION; UNCLASSIFIED DRUG; WORTMANNIN;

ABSORPTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SODIUM RETENTION; SODIUM TRANSPORT;

ABSORPTION; ANDROSTADIENES; ANIMALS; BENZOIC ACIDS; BENZYLAMINES; BICYCLO COMPOUNDS, HETEROCYCLIC; CELLS, CULTURED; EPITHELIAL CELLS; FURANS; IMMEDIATE-EARLY PROTEINS; INDAZOLES; INSULIN; ION TRANSPORT; KIDNEY TUBULES, COLLECTING; MEMBRANE POTENTIALS; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; PYRIMIDINES; QUINOXALINES; SODIUM; SULFONAMIDES;

EID: 77956320696     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00898.x     Document Type: Article

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