Differential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell lines

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Mott, Natasha N ^a   Chung, Wilson C J ^b   Tsai, Pei San ^b   Pak, Toni R ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GONADORELIN; FGFR1 PROTEIN, MOUSE; FGFR3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; AUTOREGULATION; BIOLOGICAL ACTIVITY; BRAIN NERVE CELL; CELL STRAIN 3T3; CELL STRAIN GT1 7; CELL STRAIN HT 22; CELL TYPE; CONTROLLED STUDY; GENE EXPRESSION; HYPOTHALAMUS; MOUSE; NONHUMAN; ANIMAL; BRAIN LEVEL; CELL LINE; CELL LINEAGE; CYTOLOGY; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HIPPOCAMPUS; METABOLISM; NERVE CELL; PHYSIOLOGY;

ANIMALIA; MURINAE; VERTEBRATA;

ANIMALS; BRAIN CHEMISTRY; CELL LINE; CELL LINEAGE; FIBROBLAST GROWTH FACTOR 8; FIBROBLASTS; GENE EXPRESSION REGULATION; GONADOTROPIN-RELEASING HORMONE; HIPPOCAMPUS; HYPOTHALAMUS; MICE; NEURONS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3;

EID: 77956310863     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010143     Document Type: Article

References (34)

1. Zhang X, Ibrahimi OA, Olsen SK, Umemori H, Mohammadi M, et al. (2006) Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem 281: 15694-15700.
2. Reuss B, von Bohlen und Halbach O (2003) Fibroblast growth factors and their receptors in the central nervous system. Cell Tissue Res 313: 139-157.
3. Alarid ET (2006) Lives and times of nuclear receptors. Mol Endocrinol 20: 1972-1981.
4. Bridges TM, Lindsley CW (2008) G-protein-coupled receptors: from classical modes of modulation to allosteric mechanisms. ACS Chem Biol 3: 530-541.
5. Marchese A, Chen C, Kim YM, Benovic JL (2003) The ins and outs of G protein-coupled receptor trafficking. Trends Biochem Sci 28: 369-376.
6. Scholpp S, Groth C, Lohs C, Lardelli M, Brand M (2004) Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Dev Genes Evol 214: 285-295.
7. Jen WC, Gawantka V, Pollet N, Niehrs C, Kintner C (1999) Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos. Genes Dev 13: 1486-1499.
8. Lamar E, Deblandre G, Wettstein D, Gawantka V, Pollet N, et al. (2001) Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev 15: 1885-1899.
9. Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, et al. (1999) Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 401: 480-485.
10. Niehrs C, Meinhardt H (2002) Modular feedback. Nature 417: 35-36.
11. Chung WC, Moyle SS, Tsai PS (2008) Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons. Endocrinology 149: 4997-5003.
12. Tsai PS, Moenter SM, Postigo HR, El Majdoubi M, Pak TR, et al. (2005) Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol 19: 225-236.
13. Kwabi-Addo B, Ozen M, Ittmann M (2004) The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer 11: 709-724.
14. Neufeld G, Gospodarowicz D (1985) The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells. J Biol Chem 260: 13860-13868.
15. Moscatelli D, Quarto N (1989) Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin. J Cell Biol 109: 2519-2527.
16. Estival A, Monzat V, Miquel K, Gaubert F, Hollande E, et al. (1996) Differential regulation of fibroblast growth factor (FGF) receptor-1 mRNA and protein by two molecular forms of basic FGF. Modulation of FGFR-1 mRNA stability. J Biol Chem 271: 5663-5670.
17. Guo Q, Li JY (2007) Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation. Development 134: 2251-2260.
18. Guo Q, Li K, Sunmonu NA, Li JY. Fgf8b-containing spliceforms, but not Fgf8a, are essential for Fgf8 function during development of the midbrain and cerebellum. Dev Biol 338: 183-192.
19. Andre F, Job B, Dessen P, Tordai A, Michiels S, et al. (2009) Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array. Clin Cancer Res 15: 441-451.
20. Jang JH (2005) Reciprocal relationship in gene expression between FGFR1 and FGFR3: implication for tumorigenesis. Oncogene 24: 945-948.
21. Tomlinson DC, Lamont FR, Shnyder SD, Knowles MA (2009) Fibroblast growth factor receptor 1 promotes proliferation and survival via activation of the mitogen-activated protein kinase pathway in bladder cancer. Cancer Res 69: 4613-4620.
22. Arnaud-Dabernat S, Kritzik M, Kayali AG, Zhang YQ, Liu G, et al. (2007) FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells. Diabetes 56: 96-106.
23. Arnaud-Dabernat S, Yadav D, Sarvetnick N (2008) FGFR3 contributes to intestinal crypt cell growth arrest. J Cell Physiol 216: 261-268.
24. Inglis-Broadgate SL, Thomson RE, Pellicano F, Tartaglia MA, Pontikis CC, et al. (2005) FGFR3 regulates brain size by controlling progenitor cell proliferation and apoptosis during embryonic development. Dev Biol 279: 73-85.
25. Thomson RE, Pellicano F, Iwata T (2007) Fibroblast growth factor receptor 3 kinase domain mutation increases cortical progenitor proliferation via mitogenactivated protein kinase activation. J Neurochem 100: 1565-1578.
26. Gill JC, Moenter SM, Tsai PS (2004) Developmental regulation of gonadotropin- releasing hormone neurons by fibroblast growth factor signaling. Endocrinology 145: 3830-3839.
27. Walker DM, Juenger TE, Gore AC (2009) Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats. Endocrinology 150: 2308-2316.
28. Morimoto BH, Koshland DE, Jr. (1990) Induction and expression of long- and short-term neurosecretory potentiation in a neural cell line. Neuron 5: 875-880.
29. Grand EK, Chase AJ, Heath C, Rahemtulla A, Cross NC (2004) Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074. Leukemia 18: 962-966.
30. Koziczak M, Holbro T, Hynes NE (2004) Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins. Oncogene 23: 3501-3508.
31. Mohammadi M, Froum S, Hamby JM, Schroeder MC, Panek RL, et al. (1998) Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. Embo J 17: 5896-5904.
32. Skaper SD, Kee WJ, Facci L, Macdonald G, Doherty P, et al. (2000) The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. J Neurochem 75: 1520-1527.
33. Chandran UR, Attardi B, Friedman R, Dong KW, Roberts JL, et al. (1994) Glucocorticoid receptor-mediated repression of gonadotropin-releasing hormone promoter activity in GT1 hypothalamic cell lines. Endocrinology 134: 1467-1474.
34. Pak TR, Chung WC, Roberts JL, Handa RJ (2006) Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity. Endocrinology 147: 1924-1931.