메뉴 건너뛰기




Volumn 5, Issue 4, 2010, Pages

T- and B-cell-mediated protection induced by novel, live attenuated pertussis vaccine in mice. Cross protection against parapertussis

Author keywords

[No Author keywords available]

Indexed keywords

BPZE1 VACCINE; GAMMA INTERFERON; INTERLEUKIN 17; PERTUSSIS VACCINE; UNCLASSIFIED DRUG; LIVE VACCINE;

EID: 77956307858     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010178     Document Type: Article
Times cited : (54)

References (52)
  • 2
    • 65549166748 scopus 로고    scopus 로고
    • Pertussis in early infancy: Disease burden and preventive strategies
    • McIntyre P, Wood N (2009) Pertussis in early infancy: disease burden and preventive strategies. Curr Opin Infect Dis 22: 215-223.
    • (2009) Curr Opin Infect Dis , vol.22 , pp. 215-223
    • McIntyre, P.1    Wood, N.2
  • 5
    • 20544432078 scopus 로고    scopus 로고
    • Overview of pertussis: Focus on epidemiology, sources of infection, and long term protection after infant vaccination
    • Edwards KM (2005) Overview of pertussis: focus on epidemiology, sources of infection, and long term protection after infant vaccination. Pediatr Infect Dis J 24(Suppl.): S104-S108.
    • (2005) Pediatr Infect Dis J , vol.24 , Issue.SUPPL.
    • Edwards, K.M.1
  • 7
    • 0037449067 scopus 로고    scopus 로고
    • Systematic review of the effects of pertussis vaccines in children
    • Jefferson T, Rudin M, DiPietrantonj C (2003) Systematic review of the effects of pertussis vaccines in children. Vaccine 21: 2003-2014.
    • (2003) Vaccine , vol.21 , pp. 2003-2014
    • Jefferson, T.1    Rudin, M.2    DiPietrantonj, C.3
  • 8
    • 0021350927 scopus 로고
    • Development of a pertussis component vaccine in Japan
    • Sato Y, Kimura M, Fukumi H (1984) Development of a pertussis component vaccine in Japan. Lancet 8369: 122-126.
    • (1984) Lancet , vol.8369 , pp. 122-126
    • Sato, Y.1    Kimura, M.2    Fukumi, H.3
  • 10
    • 0030734578 scopus 로고    scopus 로고
    • A safety and immunogenicity comparison of 12 acellular pertussis vaccines and one whole-cell pertussis vaccine given as a forth dose in 15- to 20- months-old children
    • Pichichero ME, Deloria MA, Rennels MB, Anderson EL, Edwards KM, et al. (1997) A safety and immunogenicity comparison of 12 acellular pertussis vaccines and one whole-cell pertussis vaccine given as a forth dose in 15- to 20- months-old children. Pediatrics 100: 772-788.
    • (1997) Pediatrics , vol.100 , pp. 772-788
    • Pichichero, M.E.1    Deloria, M.A.2    Rennels, M.B.3    Anderson, E.L.4    Edwards, K.M.5
  • 11
    • 0031590627 scopus 로고    scopus 로고
    • Randomised controlled trial of two-component, three-component, and fivecomponent acellular pertussis vaccines compared with whole-cell pertussis vaccine. Ad Hoc Group for the Study of Pertussis Vaccines
    • Olin P, Rasmussen F, Gustafsson L, Hallander HO, Heijbel H (1997) Randomised controlled trial of two-component, three-component, and fivecomponent acellular pertussis vaccines compared with whole-cell pertussis vaccine. Ad Hoc Group for the Study of Pertussis Vaccines. Lancet 334: 1569-1577.
    • (1997) Lancet , vol.334 , pp. 1569-1577
    • Olin, P.1    Rasmussen, F.2    Gustafsson, L.3    Hallander, H.O.4    Heijbel, H.5
  • 13
    • 3142632035 scopus 로고    scopus 로고
    • Epidemiology and characterization of Bordetella parapertussis strains isolated between 1995 and 2002 in and around Warsaw, Poland
    • Letowska I, Hryniewicz W (2004) Epidemiology and characterization of Bordetella parapertussis strains isolated between 1995 and 2002 in and around Warsaw, Poland. Eur J Clin Microbiol Infect Dis 23: 499-501.
    • (2004) Eur J Clin Microbiol Infect Dis , vol.23 , pp. 499-501
    • Letowska, I.1    Hryniewicz, W.2
  • 14
    • 0042355274 scopus 로고    scopus 로고
    • Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica
    • Parkhill J, Sebaihia M, Preston A, Murphy LD, Thomson N, et al. (2003) Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet 35: 32-40.
    • (2003) Nat Genet , vol.35 , pp. 32-40
    • Parkhill, J.1    Sebaihia, M.2    Preston, A.3    Murphy, L.D.4    Thomson, N.5
  • 16
    • 0032547330 scopus 로고    scopus 로고
    • Whooping cough caused by Bordetella pertussis and Bordetella parapertussis in an immunized population
    • He Q, Viljanen MK, Arvilommi H, Aittanen B, Mertsola J (1998) Whooping cough caused by Bordetella pertussis and Bordetella parapertussis in an immunized population. JAMA 280: 635-637.
    • (1998) JAMA , vol.280 , pp. 635-637
    • He, Q.1    Viljanen, M.K.2    Arvilommi, H.3    Aittanen, B.4    Mertsola, J.5
  • 17
    • 0032841169 scopus 로고    scopus 로고
    • Parapertussis and pertussis: Differences and similarities in incidence, clinical course, and antibody responses
    • Bergfors E, Trollfors B, Taranger J, Lagergard T, Sundh V, et al. (1999) Parapertussis and pertussis: differences and similarities in incidence, clinical course, and antibody responses. Int J Infect Dis 3: 140-146.
    • (1999) Int J Infect Dis , vol.3 , pp. 140-146
    • Bergfors, E.1    Trollfors, B.2    Taranger, J.3    Lagergard, T.4    Sundh, V.5
  • 18
    • 0028345170 scopus 로고
    • Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis
    • Heininger U, Stehr K, Schmitt-Grohe S, Lorenz C, Rost R, et al. (1994) Clinical characteristics of illness caused by Bordetella parapertussis compared with illness caused by Bordetella pertussis. Pediatr Infect Dis J 13: 306-309.
    • (1994) Pediatr Infect Dis J , vol.13 , pp. 306-309
    • Heininger, U.1    Stehr, K.2    Schmitt-Grohe, S.3    Lorenz, C.4    Rost, R.5
  • 19
    • 2342526002 scopus 로고    scopus 로고
    • Efficacies of whole cell and acellular pertussis vaccines against Bordetella parapertussis in a mouse model
    • David S, van Furth R, Mooi FR (2004) Efficacies of whole cell and acellular pertussis vaccines against Bordetella parapertussis in a mouse model. Vaccine 22: 1892-1898.
    • (2004) Vaccine , vol.22 , pp. 1892-1898
    • David, S.1    van Furth, R.2    Mooi, F.R.3
  • 20
    • 34848889597 scopus 로고    scopus 로고
    • The O antigen enables Bordetella parapertussis to avoid Bordetella pertussis-induced immunity
    • Wolfe DN, Goebel EM, Bjornstad ON, Restif O, Harvill ET (2007) The O antigen enables Bordetella parapertussis to avoid Bordetella pertussis-induced immunity. Infect Immun 75: 4972-4979.
    • (2007) Infect Immun , vol.75 , pp. 4972-4979
    • Wolfe, D.N.1    Goebel, E.M.2    Bjornstad, O.N.3    Restif, O.4    Harvill, E.T.5
  • 21
    • 33746622593 scopus 로고    scopus 로고
    • Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough
    • Mielcarek N, Debrie AS, Raze D, Bertout J, Rouanet C, et al. (2006) Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough. PLoS Pathog 2: e65.
    • (2006) PLoS Pathog , vol.2
    • Mielcarek, N.1    Debrie, A.S.2    Raze, D.3    Bertout, J.4    Rouanet, C.5
  • 22
    • 53149104723 scopus 로고    scopus 로고
    • Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1
    • Feunou PF, Ismaili J, Debrie AS, Huot L, Hot D, et al. (2008) Genetic stability of the live attenuated Bordetella pertussis vaccine candidate BPZE1. Vaccine 26: 5722-5727.
    • (2008) Vaccine , vol.26 , pp. 5722-5727
    • Feunou, P.F.1    Ismaili, J.2    Debrie, A.S.3    Huot, L.4    Hot, D.5
  • 23
    • 0034974006 scopus 로고    scopus 로고
    • Immunity to Bordetella pertussis
    • Mills KH (2001) Immunity to Bordetella pertussis. Microbes Infect 3: 655-677.
    • (2001) Microbes Infect , vol.3 , pp. 655-677
    • Mills, K.H.1
  • 24
    • 0030817842 scopus 로고    scopus 로고
    • Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-gamma receptor or immunoglobulin mu chain genes
    • Mahon BP, Sheahan BJ, Griffin F, Murphy G, Mills KH (1997) Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions of interferon-gamma receptor or immunoglobulin mu chain genes. J Exp Med 186: 1843-1851.
    • (1997) J Exp Med , vol.186 , pp. 1843-1851
    • Mahon, B.P.1    Sheahan, B.J.2    Griffin, F.3    Murphy, G.4    Mills, K.H.5
  • 25
    • 1442289935 scopus 로고    scopus 로고
    • Fatal case of unsuspected pertussis diagnosed from a blood culture-Minnesota, 2003
    • Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention (2004) Fatal case of unsuspected pertussis diagnosed from a blood culture-Minnesota, 2003. MMWR Morb Mortal Wkly Rep 53: 131-132.
    • (2004) MMWR Morb Mortal Wkly Rep , vol.53 , pp. 131-132
  • 26
    • 0027397437 scopus 로고
    • Cell-mediated immunity to Bordetella pertussis: Role of Th1 cells in bacterial clearance in a murine respiratory infection model
    • Mills KH, Barnard A, Watkins J, Redhead K (1993) Cell-mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model. Infect Immun 61: 399-410.
    • (1993) Infect Immun , vol.61 , pp. 399-410
    • Mills, K.H.1    Barnard, A.2    Watkins, J.3    Redhead, K.4
  • 27
    • 4644332197 scopus 로고    scopus 로고
    • Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells
    • Byrne P, McGuirk P, Todryk S, Mills KH (2004) Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells. Eur J Immunol 34: 2579-2588.
    • (2004) Eur J Immunol , vol.34 , pp. 2579-2588
    • Byrne, P.1    McGuirk, P.2    Todryk, S.3    Mills, K.H.4
  • 28
    • 0037378065 scopus 로고    scopus 로고
    • Role of antibodies in immunity to Bordetella infections
    • Kirimanjeswara GS, Mann PB, Harvill ET (2003) Role of antibodies in immunity to Bordetella infections. Infect Immun 71: 1719-1724.
    • (2003) Infect Immun , vol.71 , pp. 1719-1724
    • Kirimanjeswara, G.S.1    Mann, P.B.2    Harvill, E.T.3
  • 29
    • 0034608713 scopus 로고    scopus 로고
    • Protective immunity to Bordetella pertussis requires both B cells and CD4 (+) T cells for key functions other than specific antibody production
    • Leef M, Elkins KL, Barbic J, Shahin RD (2000) Protective immunity to Bordetella pertussis requires both B cells and CD4 (+) T cells for key functions other than specific antibody production. J Exp Med 191: 1841-1852.
    • (2000) J Exp Med , vol.191 , pp. 1841-1852
    • Leef, M.1    Elkins, K.L.2    Barbic, J.3    Shahin, R.D.4
  • 30
    • 0028157422 scopus 로고
    • Heparin-inhibitable lectin activity of the filamentous hemagglutinin adhesin of Bordetella pertussis
    • Menozzi FD, Mutombo R, Renauld G, Gantiez C, Hannah JH, et al. (1994) Heparin-inhibitable lectin activity of the filamentous hemagglutinin adhesin of Bordetella pertussis. Infect Immun 62: 769-778.
    • (1994) Infect Immun , vol.62 , pp. 769-778
    • Menozzi, F.D.1    Mutombo, R.2    Renauld, G.3    Gantiez, C.4    Hannah, J.H.5
  • 31
    • 33751579426 scopus 로고    scopus 로고
    • TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: Role of IL-17- producing T cells
    • Higgins SC, Jarnicki AG, Lavelle ED, Mills KHG (2006) TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17- producing T cells. J Immunol 177: 7980-7989.
    • (2006) J Immunol , vol.177 , pp. 7980-7989
    • Higgins, S.C.1    Jarnicki, A.G.2    Lavelle, E.D.3    Mills, K.H.G.4
  • 32
    • 34248206737 scopus 로고    scopus 로고
    • Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells
    • Chen X, Howard OMZ, Oppenheim JJ (2007) Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells. J Immunol 178: 6123-6129.
    • (2007) J Immunol , vol.178 , pp. 6123-6129
    • Chen, X.1    Howard, O.M.Z.2    Oppenheim, J.J.3
  • 33
    • 0037148511 scopus 로고    scopus 로고
    • Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: A novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    • McGuirk P, McCann C, Mills KH (2002) Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med 195: 221-231.
    • (2002) J Exp Med , vol.195 , pp. 221-231
    • McGuirk, P.1    McCann, C.2    Mills, K.H.3
  • 34
    • 0031882161 scopus 로고    scopus 로고
    • A murine model in which protection correlates with pertussis vaccine efficacy in children reveals complementary roles for humoral and cell-mediated immunity in protection against Bordetella pertussis
    • Mills KHG, Ryan M, Ryan E, Mahon BP (1998) A murine model in which protection correlates with pertussis vaccine efficacy in children reveals complementary roles for humoral and cell-mediated immunity in protection against Bordetella pertussis. Infect Immun 66: 594-602.
    • (1998) Infect Immun , vol.66 , pp. 594-602
    • Mills, K.H.G.1    Ryan, M.2    Ryan, E.3    Mahon, B.P.4
  • 35
    • 2942550802 scopus 로고    scopus 로고
    • Whooping cough due to Bordetella parapertussis: An unresolved problem
    • Watanabe M, Nagai M (2004) Whooping cough due to Bordetella parapertussis: an unresolved problem. Expert Rev Anti-infect Ther 2: 447-454.
    • (2004) Expert Rev Anti-infect Ther , vol.2 , pp. 447-454
    • Watanabe, M.1    Nagai, M.2
  • 36
    • 0034783459 scopus 로고    scopus 로고
    • Reciprocal protective immunity against Bordetella pertussis and Bordetella parapertussis in a murine model of respiratory infection
    • Watanabe M, M Nagai (2001) Reciprocal protective immunity against Bordetella pertussis and Bordetella parapertussis in a murine model of respiratory infection. Infect Immun 69: 6981-6986.
    • (2001) Infect Immun , vol.69 , pp. 6981-6986
    • Watanabe, M.1    Nagai, M.2
  • 38
    • 0037309323 scopus 로고    scopus 로고
    • Bordetella pertussis infection in 2-months-old infants promotes type 1 T cell responses
    • Mascart F, Verscheure V, Malfroot A, Hainaut M, Piérard D, et al. (2003) Bordetella pertussis infection in 2-months-old infants promotes type 1 T cell responses. J Immunol 170: 1504-1509.
    • (2003) J Immunol , vol.170 , pp. 1504-1509
    • Mascart, F.1    Verscheure, V.2    Malfroot, A.3    Hainaut, M.4    Piérard, D.5
  • 39
    • 46249101937 scopus 로고    scopus 로고
    • Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells
    • Woolard MD, Hensley LL, Kahula TH, Frelinger JA (2008) Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells. Infect Immun 76: 2651-2659.
    • (2008) Infect Immun , vol.76 , pp. 2651-2659
    • Woolard, M.D.1    Hensley, L.L.2    Kahula, T.H.3    Frelinger, J.A.4
  • 40
    • 46949089128 scopus 로고    scopus 로고
    • Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
    • Ma CS, Chew GYJ, Simpson N, Priyadarshi A, Wong M, et al. (2008) Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3. J Exp Med 205: 1551-1557.
    • (2008) J Exp Med , vol.205 , pp. 1551-1557
    • Ma, C.S.1    Chew, G.Y.J.2    Simpson, N.3    Priyadarshi, A.4    Wong, M.5
  • 41
    • 1542289741 scopus 로고    scopus 로고
    • Plasma cell-like morphology of Th1-cytokine-producing cells associated with the of CD3 expression
    • Page G, Sattler A, Kersten S, Thiel A, Radbruch A, et al. (2004) Plasma cell-like morphology of Th1-cytokine-producing cells associated with the of CD3 expression. Am J Path 164: 409-417.
    • (2004) Am J Path , vol.164 , pp. 409-417
    • Page, G.1    Sattler, A.2    Kersten, S.3    Thiel, A.4    Radbruch, A.5
  • 42
    • 32244442562 scopus 로고    scopus 로고
    • TGFb in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-prodicing T cells
    • Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B (2006) TGFb in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-prodicing T cells. Immunity 24: 179-189.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 44
    • 58149311503 scopus 로고    scopus 로고
    • Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta
    • Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, et al. (2008) Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta. J Immunol 181: 4485-4494.
    • (2008) J Immunol , vol.181 , pp. 4485-4494
    • Rowan, A.G.1    Fletcher, J.M.2    Ryan, E.J.3    Moran, B.4    Hegarty, J.E.5
  • 45
    • 68149169634 scopus 로고    scopus 로고
    • Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10 dependent mechanisms
    • Nasso M, Fedele G, Spensieri F, Palazzo R, Costantino P, et al. (2009) Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10 dependent mechanisms. J Immunol 183: 1892-1899.
    • (2009) J Immunol , vol.183 , pp. 1892-1899
    • Nasso, M.1    Fedele, G.2    Spensieri, F.3    Palazzo, R.4    Costantino, P.5
  • 46
    • 47949106642 scopus 로고    scopus 로고
    • Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis differently modulate human dendritic cell functions resulting in divergent prevalence of Th17-polarized responses
    • Fedele G, Nasso M, Stensieri F, Palazzo R, Frasca L, et al. (2008) Lipopolysaccharides from Bordetella pertussis and Bordetella parapertussis differently modulate human dendritic cell functions resulting in divergent prevalence of Th17-polarized responses. J Immunol 181: 208-216.
    • (2008) J Immunol , vol.181 , pp. 208-216
    • Fedele, G.1    Nasso, M.2    Stensieri, F.3    Palazzo, R.4    Frasca, L.5
  • 47
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6: 1123-1132.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5
  • 48
    • 55149090692 scopus 로고    scopus 로고
    • Th17 cytokines and mucosal immunity
    • Dubin PJ, Kolls JK (2008) Th17 cytokines and mucosal immunity. Immunol Rev 226: 160-171.
    • (2008) Immunol Rev , vol.226 , pp. 160-171
    • Dubin, P.J.1    Kolls, J.K.2
  • 49
    • 0026706341 scopus 로고
    • Common accessory genes for the Bordetella pertussis filamentous hemagglutinin and fimbrae share sequence similarities with the papC and papD gene families
    • Locht C, Geoffroy MC, Renauld G (1992) Common accessory genes for the Bordetella pertussis filamentous hemagglutinin and fimbrae share sequence similarities with the papC and papD gene families. EMBO J 11: 3175-3183.
    • (1992) EMBO J , vol.11 , pp. 3175-3183
    • Locht, C.1    Geoffroy, M.C.2    Renauld, G.3
  • 50
    • 0025338668 scopus 로고
    • Roles of the disulfide bond and the carboxy-terminal region of the S1 subunit in the assembly and biosynthesis of pertussis toxin
    • Antoine R, Locht C (1990) Roles of the disulfide bond and the carboxy-terminal region of the S1 subunit in the assembly and biosynthesis of pertussis toxin. Infect Immun 58: 1518-1526.
    • (1990) Infect Immun , vol.58 , pp. 1518-1526
    • Antoine, R.1    Locht, C.2
  • 51
    • 0021100514 scopus 로고
    • Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase
    • Sekura RD, Fish F, Manckark CR, Meade B, Zhang YL (1983) Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase. J Biol Chem 258: 14647-14651.
    • (1983) J Biol Chem , vol.258 , pp. 14647-14651
    • Sekura, R.D.1    Fish, F.2    Manckark, C.R.3    Meade, B.4    Zhang, Y.L.5
  • 52
    • 0026110272 scopus 로고
    • Interaction of Bordetella pertussis filamentous hemagglutinin with heparin
    • Menozzi FD, Gantiez C, Locht C (1991) Interaction of Bordetella pertussis filamentous hemagglutinin with heparin. FEMS Microbiol Lett 78: 59-64.
    • (1991) FEMS Microbiol Lett , vol.78 , pp. 59-64
    • Menozzi, F.D.1    Gantiez, C.2    Locht, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.